冠心病患者血清ANGPTL6水平及其与冠脉病变严重程度的关系

ANGPTL6 Level in Patient with Coronary Heart Disease and Its Relationship with the Severity of Coronary Artery Lesions

摘要: 背景和目的：血管生成素相关生长因子(ANGPTL6)能增加能量消耗，抵抗肥胖；加强胰岛素敏感性；改善缺血小鼠肢体再灌注，降低截肢及长期心血管并发症的风险。研究预测ANGPTL6可能与心血管疾病有关。然而，目前在冠心病方面的研究很少。本研究旨在确定ANGPTL6在冠心病患者血清中的表达水平，以及其与冠状动脉狭窄程度、临床参数间的关系。方法：收集2018年1月至2018年12月期间入住青岛市市立医院心内科患者500例。所有患者均接受冠脉造影检查，从中筛选出年龄、性别、体重指数糖尿病史、高血压病史，吸烟史等无明显统计学差异的120例患者，采用酶联免疫法测定急性心肌梗死(AMI)、稳定型心绞痛(SAP)和正常对照组各40例患者血清ANGPTL6浓度。根据造影结果，用Gensini评分评估冠状动脉狭窄程度，分析ANGPTL6与Gensini评分相关性。结果：AMI患者血清ANGPTL6表达水平低于对照组，差异具有统计学意义(P < 0.05)。SAP组ANGPTL6浓度与对照组之间无明显差异(P > 0.05)。AMI和SAP患者血清ANGPTL6浓度与Gensini评分显著负相关(r = −0.514, P < 0.05; r = −0.467, P < 0.05)。结论：冠心病患者血清ANGPTL6水平与冠状动脉严重程度呈负相关，提示ANGPTL6与冠心病具有潜在相关性。

Abstract: Background and Objective: Angiogenin-related growth factor (ANGPTL6) can increase energy consumption to resist obesity, improve insulin sensitivity and reduce insulin resistance; it also improves limb reperfusion in ischemic mice, greatly reducing the risk of amputation and long-term cardiovascular complications. Many studies have predicted that ANGPTL6 might be associated with cardiovascular diseases. However, few studies had been done so far on coronary heart disease. Our study aimed to determine the level of ANGPTL6 in coronary heart disease, and its relationship with the degree of coronary artery stenosis and clinical indicators. Methods: A total of 500 patients admitted to the department of cardiology of Qingdao Municipal Hospital from January 2018 to December 2018 were collected. All patients received coronary angiography, from which 120 patients with no statistically significant differences in age, gender, body mass index, history of diabetes, history of hypertension, and history of smoking were screened. Serum ANGPTL6 level in 40 cases of acute myocardial infarction (AMI), 40 cases of stable angina pectoris (SAP) and 40 cases of normal control group were measured by enzyme-linked immunoassay. According to the angiography results, the degree of coronary artery stenosis was calculated by Gensini score, and the correlation between ANGPTL6 and Gensini score was analyzed. Results: The serum ANGPTL6 level of AMI was lower than the control group (P < 0.05). ANGPTL6 concentration had no significant difference between stable angina pectoris and normal group (P > 0.05). In patients with acute myocardial infarction and stable angina pectoris, ANGPTL6 concentration was significantly correlated with Gensini score (r = −0.514, P < 0.05; r = −0.467, P < 0.05). Conclusion: In patients with coronary heart disease, its level is negatively correlated with coronary artery severity, suggesting that ANGPTL6 might be potentially associated with coronary heart disease.