一株BK病毒的基因型鉴定
Genotype Identification of a Strain of BK Virus
DOI: 10.12677/AMB.2020.92003, PDF,    科研立项经费支持
作者: 陈 倩, 吕颂雅*：武汉大学，病毒学国家重点实验室，湖北 武汉；朱淑敏, 屈三甫：武汉大学，病毒学国家重点实验室，湖北 武汉；武汉大学，中国典型培养物保藏中心，湖北 武汉
关键词: BK病毒；BK病毒相关疾病；进化分析；BK Virus； BK Virus-Related Diseases； Evolutionary Analysis
摘要: BK病毒(BKV)是一种多瘤病毒，最早在1971年报道，并用该病人姓名命名。BK病毒在成人中隐形感染率达到80%。近年来由BK病毒引起的肾病、血性膀胱炎、急性肾功能衰竭等疾病越来越引起关注。目前还没有直接针对BK病毒的免疫预防策略，不存在抗BK病毒的疫苗。本文对来源于中国典型培养物保藏中心的一株BK病毒的VP1基因进行了测序及进化树分析，结果表明该毒株为I亚型Ib-1毒株。本鉴定结果为该病毒的进一步研究和应用奠定了基础。
Abstract: The BK virus (BKV) is a polyomavirus first reported in 1971 and named after the patient. The BK virus has an invisible infection rate of 80% in adults. In recent years, diseases such as nephropathy, blood cystitis, and acute renal failure caused by BK virus have attracted increasing attention. There is currently no immune prevention strategy directed against BK virus, and there is no vaccine against BK virus. In this paper, the results of sequencing and phylogenetic analysis of the VP1 gene of a BK virus from the China Center for Type Culture Collection, showed that the strain was I subtype Ib-1 strain. The identification results laid the foundation for further research and application of the virus.
文章引用：陈倩, 朱淑敏, 屈三甫, 吕颂雅. 一株BK病毒的基因型鉴定[J]. 微生物前沿, 2020, 9(2): 17-21. https://doi.org/10.12677/AMB.2020.92003

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