慢性中心性浆液性脉络膜视网膜病变视功能与视网膜结构的相关性研究

Study on the Correlation between Visual Function and Retinal Structure in Chronic Central Serous Chorioretinopathy

摘要: 目的：观察慢性中心性浆液性脉络膜视网膜病变(CSC)患者视功能与视网膜结构的相关性。方法：回顾性病例分析。临床确诊的慢性CSC患者25例25眼纳入研究。男性17人，女性8人。年龄39~65岁，平均年龄53.24  8.72岁。采用国际标准视力表行BCVA检查，统计时换算为最小分辨角对数(logMAR)视力。采用MAIA微视野计检测黄斑10˚的黄斑完整性指数(MI)、平均视网膜敏感度(AT)、2˚固视率(P1)、4˚固视率(P2)。采用光相干断层扫描(OCT)测量中心凹下脉络膜厚度(SFCT)、视网膜下液高度(SRFH)。各影响因素之间相关性采用Pearson相关性分析。结果：Pearson相关分析结果显示，logMAR BCVA与SFCT (r = 0.808, p = 0.001)、SRFH (r = 0.604, p = 0.004)呈正相关，与AT (r = −0.621, p = 0.003)呈负相关。AT与SFCT (r = −0.724, p = 0.000)、MI (r = −0.331, p = 0.007)呈负相关。结论：慢性CSC患者logMAR BCVA与SFCT、SRFH呈正相关，与AT呈负相关。微视野检查、视力联合OCT对于慢性CSC患者黄斑部结构与功能变化相关性的评价具有重要意义。

Abstract: Purpose: To investigate the association between visual function and retinal structure in central serous chorioretinopathy (CSC). Method: A retrospective study. Twenty-five eyes of 25 patients in chronic CSC were included. There were 17 eyes of 17 males, 8 eyes of 8 females, with an average age of 53.24  8.72 years. The BCVA examination was performed using the international standard visual acuity chart, which was converted into logarithmic logarithm (IogMAR) visual acuity. The following parameters provided by the MAIA microperimetry device were evaluated, including average threshold (AT), macular integrity index (MI), 2˚ and 4˚ fixation indexes (P1 and P2). And parameters measured by optical coherence tomography (OCT) were also evaluated, including subfoveal choroidal thickness (SFCT) and the height of subretinal fluid (SRFH). Pearson correlation analysis was used to analyze the correlation between the factors. Result: The results of Pearson correlation analysis showed that the logMAR BCVA was positively correlated with SFCT (r = 0.808, p = 0.001) and SRFH (r = 0.604, p = 0.004), but it was negatively correlated with AT (r = −0.621, p = 0.003). AT was negatively correlated with SFCT (r = −0.724, p = 0.000) and MI (r = −0.331, p = 0.007). Conclusion: In chronic CSC patients, the logMAR BCVA was positively correlated with SFCT and SRFH, but was negatively correlated with AT. Microperimetry combined with OCT and visual acuity can be used to assess the visual function of patients with chronic CSC.