肠道菌群与结核杆菌感染相关的研究进展
Research Progress on the Relationship between Gut Microbiota and Mycobacterium Tuberculosis Infection
DOI: 10.12677/ACM.2020.106148, PDF,   
作者: 李百远, 李元军：延安大学附属医院，陕西 延安
关键词: 肠道菌群；肺结核；菌群失调；免疫；Gut Microbiota； Tuberculosis； Dysbacteriosis； Immune
摘要: 随着全基因组测序的发展，肠道菌群成为学术界研究热点。肠道菌群参与人体多种生理活动，并与多种疾病发生有关。肠道菌群与呼吸道疾病，尤其是与结核病之间的研究颇受关注。研究证实肠道菌群失调可影响宿主对结核分枝杆菌的易感性，感染结核分枝杆菌会导致宿主肠道菌群的改变。两者通过宿主免疫反应、肠道菌群代谢产物等相互影响。因此，本文就结核杆菌感染与肠道菌群的关系及相关作用机制等进行综述，为结核病治疗提供新思路。
Abstract: With the development of whole genome sequencing, gut microbiota has become the focus of academic research. It is known that gut microbiota is involved in a variety of physiological activities of the human body, and is related to the occurrence of a variety of diseases. Much attention has been paid to the relationship between gut microbiota and respiratory diseases, especially tuberculosis. Studies have confirmed that gut dysbacteriosis can affect the host susceptibility to mycobacterium tuberculosis, infection with mycobacterium tuberculosis will lead to changes in the host gut microbiota. The two interact with each other through host immune response, gut microbiota metabolites and so on. Therefore, the relationship and the relevant mechanism were reviewed in order to provide new ideas for the treatment of tuberculosis.
文章引用：李百远, 李元军. 肠道菌群与结核杆菌感染相关的研究进展[J]. 临床医学进展, 2020, 10(6): 975-980. https://doi.org/10.12677/ACM.2020.106148

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