关于肌少症患者心肌质量改变的研究

Effect of Sarcopenia on Myocardial Mass in Patients with Chronic Heart Failure

摘要: 目的：探讨慢性心力衰竭(CHF)患者中肌少症除对心肌质量的影响。方法：试验设计属于回顾性研究，以2018年1月1日至2019年10月30日期间符合条件的120例CHF患者为研究对象，根据肌少症诊断标准分为肌少症组(43例)与非肌少症组(77例)，记录一般临床资料。对每位患者进行心脏超声检查，根据测量结果计算心肌质量。比较两组心肌质量的差异性。结果：肌少症组和非肌少症组年龄、B型利钠肽、高敏肌钙蛋白、左心室射血分数、心功能分级和心肌质量比较，差异均有统计学意义(均为P < 0.05)；对SMI与LVM进行相关性分析，研究结果显示SMI与LVM呈显著线性正相关(r = 0.869, P < 0.001)。结论：肌少症不仅可使CHF患者骨骼肌质量下降，对心肌质量也有削减作用，对CHF患者的远期预后生存指数存在显著影响。这有助于临床对CHF患者的预防性治疗。

Abstract: Objective: To explore the effect of sarcopenia on the quality of myocardium in patients with chronic heart failure (CHF). Methods: The trial design was a retrospective study. 120 CHF patients who met the conditions between January 1, 2018 and October 30, 2019 were selected as the research object. They were divided into 2 groups (sarcopenia group 43 cases and non-sarcopenia group 77 cases) according to the diagnostic criteria of sarcopenia. General clinical data were recorded. Perform cardiac ultrasound examination on each patient and calculate myocardial mass based on the measurement results. Compare the differences in myocardial mass between the two groups. Results: There were significant differences in the age, BNP, high-sensitivity troponin, left ventricular ejection fraction, cardiac function grading, and myocardial quality in the sarcopenia group and the non-sarcopnia group (all P < 0.05); Correlation analysis of SMI and LVM, the results show that SMI and LVM showed a significant linear positive correlation (r = 0.869, P< 0.001). Conclusion: Sarcopenia can not only reduce the skeletal muscle mass of CHF patients, but also reduce the quality of myocardium, and have a significant impact on the long-term prognostic survival index of CHF patients. This helps clinical preventive treatment of CHF patients.