非糜烂性反流病在蓝激光放大内镜下的形态学改变

Morphological Changes of Non-Erosive Reflux Disease under Blue Laser Magnification Endoscopy

摘要: 目的：探讨非糜烂性反流病(Non-Erosive Reflux Disease, NERD)在蓝激光放大内镜下的黏膜形态学改变。方法：选取53例非糜烂性反流病患者作为NERD组，招募20名志愿者作为健康对照组，两组均进行蓝激光放大内镜检查，分别在白光和蓝激光成像亮度(Blue Laser Imaging Bright, BLI-bright)模式下观察食管下段黏膜，再以蓝激光成像加放大(Blue laser imaging + Magnification Endoscopy, BLI + ME)模式观察食管乳头内毛细血管襻(Intrapapillary capillary loop, ICPL)形态并分型。结果：BLI + ME模式下健康对照组食管IPCL呈茶色规律排列的卷发状、小螺旋状。84.9%的NERD组表现为IPCL形态扩张和(或)延长，但仍排列规律，与健康对照组比较差异有显著性(P < 0. 05)。结论：NERD在蓝激光放大内镜下可见黏膜微结构改变，表现为IPCL延长和(或)扩张。

Abstract: Objective: To investigate the morphological changes of non-erosive reflux disease (NERD) under blue laser magnification endoscopy. Methods: Fifty-three patients with non-erosive reflux disease were selected as the NERD group, and twenty volunteers were recruited as the healthy control group. Blue laser magnification endoscopy was performed in both groups. The lower esophageal mucosa was first observed under the white light and Blue Laser Imaging Bright (BLI-bright) mode. Then, observe the morphology of the intrapapillary capillary loop (ICPL) was observed and classified under Blue Laser imaging + Magnification Endoscopy (BLI + ME) mode. Results: Under BLI + ME mode, the IPCL of the healthy control group was arranged in the shape of curly hair and small spiral. 84.9% of NERD group showed expansion and/or extension of IPCL morphology, but the arrangement was still regular, which was significantly different from that of healthy control group (P < 0.05). Conclusion: The patients with NERD can see the mucosal microstructure changes under blue laser magnification endoscopy. Changes manifest as expansion and/or extension of IPCL.