高迁移率族蛋白1与药物性肝损伤的相关研究
Study on the Relationship between High Mobility Group Box 1 and Drug-Induced Liver Injury
摘要: 高迁移率族蛋白1 (HMGB1)是一种高度通用，且无处不在的非组蛋白，属于HMGB蛋白家族。HMGB1在细胞核内参与许多DNA事件，例如DNA转录，复制，修复和重组；除其细胞内功能外，HMGB1还可在细胞外空间释放，通过损伤相关分子模式，促进炎症微环境的发生。高迁移率族蛋白1 (HMGB1)是协调药物性肝损伤(DILI)中炎症反应的关键蛋白，在DILI的早期预测，治疗和预后方面都有重要意义。该文就HMGB1与药物性肝损伤的相关研究做一综述。
Abstract: High mobility group protein 1 (HMGB1) is a highly versatile and ubiquitous non-histone protein belonging to the HMGB protein family. HMGB1 participates in many DNA events in the nucleus, such as DNA transcription, replication, repair, and recombination; in addition to its intracellular function, HMGB1 can also be released in the extracellular space, and promote the occurrence of inflammatory microenvironment through damage-related molecular patterns. High mobility group protein 1 (HMGB1) is a key protein for coordinating the inflammatory response in drug-induced liver injury (DILI), and has important significance in the early prediction, treatment and prognosis of DILI. This article currently reviews the research related to HMGB1 and drug-induced liver injury.
文章引用：李敏, 古巧燕. 高迁移率族蛋白1与药物性肝损伤的相关研究[J]. 临床医学进展, 2020, 10(6): 1097-1101. https://doi.org/10.12677/ACM.2020.106165

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