NLRP3在心血管疾病中的研究进展
Research Perspectives of NLRP3 in the Pathogenesis of Cardiovascular Diseases
DOI: 10.12677/ACM.2020.106166, PDF,    国家自然科学基金支持
作者: 郑 梦, 陆 地, 李丽梅, 李 庆, 边立功, 黄 曦, 王娇云, 郭家智*:昆明医科大学生物医学工程研究中心,云南 昆明;杨洪财:昆明医科大学第一附属医院,云南 昆明
关键词: NLRP3炎症小体IL-1βCaspase-1心血管疾病NLRP3 Inflammation IL-1β Caspase-1 Cardiovascular Diseases
摘要: NLRP3炎症小体是一种与炎症反应息息相关的大分子多蛋白复合物。NLRP3炎症小体的组装和激活与高血压、动脉粥样硬化、心肌梗死等多种心血管疾病病理过程相关。研究NLRP3炎症小体在心血管相关疾病中的作用,可以为心血管疾病提供新的治疗方案。本文主要对NLRP3炎症小体在心血管疾病上的研究进展做一简要概述。
Abstract: NLRP3 inflammasome is a key multiprotein signaling platform that tightly controls inflammatory responses. NLRP3 has been identified to play a central role in the pathological progression of certain cardiovascular diseases, such as hypertension, vascular damage spanning atherosclerosis and other myocardial infarction. The study of the NLRP3 inflammasome in these cardiovascular disease states may lead to new treatment strategies. This review outlines current insights into NLRP3 inflammasome research associated with cardiovascular diseases and discusses the questions that remain in this field.
文章引用:郑梦, 陆地, 李丽梅, 李庆, 边立功, 杨洪财, 黄曦, 王娇云, 郭家智. NLRP3在心血管疾病中的研究进展[J]. 临床医学进展, 2020, 10(6): 1102-1107. https://doi.org/10.12677/ACM.2020.106166

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