CEA和D-二聚体检测对胃癌诊断及手术后患者预后的评估价值

The Value of CEA and D-Dimer Detection in the Diagnosis of Gastric Cancer and the Prognosis of Patients after Surgery

摘要: 目的：通过检测胃癌患者手术前癌胚抗原(CEA)及D-二聚体浓度，研究其与胃癌检测阳性率及预后之间的关系。方法：收集胃癌患者手术前血液学指标及基本信息，用Kaplan-Meier法绘制生存曲线，用Cox比例风险模型进行多因素分析。结果：早期组胃癌患者术前CEA及D-二聚体浓度显著低于晚期组，联合检测CEA及D-二聚体较单项检测胃癌阳性率更高。血清D-二聚体浓度与患者术后生存时间相关，肿瘤分期是影响患者生存的独立预后因素。结论：联合检测CEA及D-二聚体在提高胃癌检出率、评估患者预后方面可发挥积极作用。

Abstract: Objective: To study the relationship between the pre-operative carcinoembryonic antigen (CEA) and D-dimer concentration in gastric cancer patients and the positive rate and prognosis of gastric cancer detection. Methods: Collect the hematological indexes and basic information of gastric cancer patients before operation, use Kaplan-Meier method to draw survival curve, and use Cox proportional hazard model for multi-factor analysis. Results: The concentration of CEA and D-dimer in patients with gastric cancer in the early group was significantly lower than that in the late group. The combined detection of CEA and D-dimer was higher than the single detection of gastric cancer. Serum D-dimer concentration is related to the survival time of patients after surgery, and tumor stage is an independent prognostic factor that affects the survival of patients. Conclusion: The combined detection of CEA and D-dimer can play an active role in improving the detection rate of gastric cancer and evaluating the prognosis of patients.