糖尿病足的预防及治疗进展
Advances in Prevention and Treatment of Diabetic Foot
DOI: 10.12677/ACM.2020.107181, PDF,   
作者: 钱洪发, 张韵凯, 吴 亮*:中国药科大学,江苏 南京
关键词: 糖尿病糖尿病足预防治疗Diabetes Mellitus Diabetic Foot Prevention Treatment
摘要: 糖尿病足为糖尿病后期严重并发症,是一种常见的致残性溃疡,患者截肢及死亡率很高。糖尿病足的发病机制复杂,临床表现多变。治疗早期应以预防溃疡出现为主,针对周围神经病变和关节活动受限引起的感染、外周缺血和感觉异常等进行干预。若感染溃疡出现,应及时采用内科及外科手术疗法辅助治疗,以降低截肢及死亡率。本文主要对糖尿病足在临床上的预防手段、内科疗法及外科手术辅助疗法进行综述。
Abstract: Diabetic foot is a serious complication of late diabetes and is a common disabling ulcer with a high rate of amputation and mortality. The pathogenesis of diabetic foot is complex and the clinical manifestations are variable. Early treatment should focus on preventing the appearance of ulcers, with interventions targeting infections, peripheral ischemia, and sensory abnormalities caused by peripheral neuropathy and joint motion restriction. If infected ulcers are present, prompt medical and surgical treatment should be adjunctive to reduce amputation and mortality. This article will review the means of prevention, internal medicine therapies and surgical adjuncts for the diabetic foot in clinical practice.
文章引用:钱洪发, 张韵凯, 吴亮. 糖尿病足的预防及治疗进展[J]. 临床医学进展, 2020, 10(7): 1186-1190. https://doi.org/10.12677/ACM.2020.107181

参考文献

[1] Apelqvist, J., Bakker, K., Van Houtum, W.H., et al. (2008) Practical Guidelines on the Management and Prevention of the Diabetic Foot: Based upon the International Consensus on the Diabetic Foot (2007) Prepared by the International Working Group on the Diabetic Foot. Diabetes/Metabolism Research and Reviews, 24, S181-S187. [Google Scholar] [CrossRef] [PubMed]
[2] Jeffcoate, W.J. and Harding, K.G. (2003) Diabetic Foot Ulcers. The Lancet, 361, 1545-1551. [Google Scholar] [CrossRef
[3] Oyibo, S.O., Jude, E.B., Tarawneh, I., et al. (2001) A Comparison of Two Diabetic Foot Ulcer Classification Systems: The Wagner and the University of Texas Wound Classification Systems. Diabetes Care, 24, 84-88. [Google Scholar] [CrossRef] [PubMed]
[4] Halpin-Landry, J.E. and Goldsmith, S. (1999) Feet First. Diabetes Care. American Journal of Nursing, 99, 26-33. https://pubmed.ncbi.nlm.nih.gov/10036568 [Google Scholar] [CrossRef
[5] Mayhfield, J.A., Reiber, G.E. and Sanders, L.J. (1998) Preventive Foot Care in People with Diabetes. Diabetes Care, 21, 2178. https://pubmed.ncbi.nlm.nih.gov/9839112 [Google Scholar] [CrossRef
[6] Izenstein, B.Z. (1997) Ellenberg and Rifkin’s Diabetes Mellitus. Journal of the American Medical Association, 277, 1817. https://jamanetwork.com/journals/jama/article-abstract/416805 [Google Scholar] [CrossRef
[7] 朱嘉雯, 李滢, 吴媛, 等. 对糖尿病患者预防糖尿病足的知识与行为调查分析[J]. 中华现代护理学杂志, 2004, 1(4): 346-347.
[8] 陈琼芳. 糖尿病足的预防与护理进展[J]. 中华护理杂志, 2002, 37(4): 292-294.
[9] Khairoun, M., Van Den Heuvel, M., Van Den Berg, B.M., et al. (2015) Early Systemic Microvascular Damage in Pigs with Atherogenic Diabetes Mellitus Coincides with Renal Angiopoietin Dysbalance. PLoS ONE, 10, e0121555. [Google Scholar] [CrossRef] [PubMed]
[10] Schaper, N.C., Van Netten, J.J., Apelqvist, J., et al. (2017) Prevention and Management of Foot Problems in Diabetes: A Summary Guidance for Daily Practice 2015, Based on the IWGDF Guidance Documents. Diabetes Research and Clinical Practice, 124, 84-92. [Google Scholar] [CrossRef] [PubMed]
[11] Zhang, S.S., Tang, Z.Y., Ping, F., et al. (2013) Nutritional Status Deteriorates as the Severity of Diabetic Foot Ulcers Increases and Independently Associates with Prognosis. Experimental & Therapeutic Medicine, 5, 215-222. [Google Scholar] [CrossRef] [PubMed]
[12] Rooke, T.W., Hirsch, A.T., Misra, S., et al. (2011) ACCF/AHA Focused Update of the Guideline for the Management of Patients with Peripheral Artery Disease (Updating the 2005 Guideline): A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology, 58, 2020-2045. [Google Scholar] [CrossRef] [PubMed]
[13] 曹凤林, 郭剑超, 王艳萍, 等. 糖尿病足患者血小板相关参数的变化及抗血小板聚集治疗[J]. 天津医药, 2006, 34(12): 856-857.
[14] 姜鹏, 许樟荣. 糖尿病足溃疡合并感染的抗生素治疗进展[J]. 中国糖尿病杂志, 2012, 4(2): 123-125.
[15] Saad Setta, H., Elshahat, A., Elsherbiny, K., et al. (2011) Platelet-Rich Plasma versus Platelet-Poor Plasma in the Management of Chronic Diabetic Foot Ulcers: A Comparative Study. International Wound Journal, 8, 307-312. [Google Scholar] [CrossRef
[16] Sun, X., Chen, J., Zhang, J., et al. (2016) Maggot Debridement Therapy Promotes Diabetic Foot Wound Healing by Up-Regulating Endothelial Cell Activity. Journal of Diabetic Complications, 30, 318-322. [Google Scholar] [CrossRef] [PubMed]
[17] 赵翠华, 王俊霞, 钱红. 中药制剂股动脉加压灌注治疗糖尿病足及护理[J]. 河北医药, 2014(14): 2212-2214.
[18] Shchudlo, N., Varsegova, T., Stupina, T., et al. (2017) Benefits of Ilizarov Automated Bone Distraction for Nerves and Articular Cartilage in Experimental Leg Lengthening. World Journal of Orthopedics, 8, 688. [Google Scholar] [CrossRef] [PubMed]
[19] 李晓辉, 张永红. 糖尿病足最新治疗进展[J]. 中华全科医学, 2018, 16(6): 993-997.
[20] 刘毅, 唐哲明, 毛庆龙, 等. 彩色多普勒超声评价胫骨横向骨搬移术治疗老年糖尿病足的临床疗效[J]. 中国老年学, 2017, 37(11): 2751-2752.