肠道菌群在自身免疫性肝病中的治疗进展

Progress of Intestinal Flora in the Treatment of Autoimmune Liver Disease

摘要: 已经有研究证明肠道菌群失调可以导致人体多器官多系统病变，肠道微生物以其组成上的多样性、结构上的复杂性来维持稳态，调节人体生理机能和病理状态。免疫系统是人体一个重要的防御系统，影响因素众多，其中肠道菌群在维持人体免疫系统稳态的过程中发挥重要作用。因此建立和维持肠道菌群与免疫系统之间的和谐关系是保障机体健康的关键。近年来不少研究提出肠道菌群在自身免疫性肝病的发生发展中起到了重要作用，激起了广大学者的研究热情，因此人们开始探索通过调节肠道菌群来治疗自身免疫性肝病并取得了确切的疗效。本文就通过调节肠道菌群治疗自身免疫性肝病的进展做一综述。

Abstract: Studies have shown that disorders of intestinal flora can lead to diseases of multiple organs and systems in the human body. Intestinal microorganisms maintain homeostasis and regulate physi-ological function and pathological state of human body with their diversity in composition and complexity in structure. Immune system is an important defense system of human body, and there are many influencing factors, among which intestinal flora plays an important role in maintaining the homeostasis of human immune system. Therefore, establishing and maintaining a harmonious relationship between the intestinal flora and the immune system is the key to ensure the health of the body. In recent years, many studies have suggested that intestinal flora plays an important role in the development of autoimmune liver disease, which has aroused the enthusiasm of many scholars, therefore, people began to explore the treatment of autoimmune liver disease by regu-lating intestinal flora and achieved a definite effect. This article reviews the progress of treating autoimmune liver disease by regulating intestinal flora.