血常规参数对转移性胃癌患者的预后分析

Prognostic Significance of the Bloodcell Parameters in Patients with Metastatic Gastric Cancer

摘要: 目的：本研究探讨中性粒细胞与淋巴细胞比值(NLR)及血小板与淋巴细胞比值(PLR)与转移性胃癌(metastatic gastric carcer, mGC)患者临床病例特征关系及预后的影响。方法：本文采用回顾性统计分析方法，搜集我院的110例确诊为IV期转移性胃癌的患者的临床病理特征。统计分析在SPSS 24.0统计软件中进行。用Kaplan-Meier方法绘制总生存期(OS, Overall Survival)、无进展生存期(PFS, Progression Free Survival)与NLR、PLR的关系。Cox比例危险度模型评价OS、PFS的相关危险因素。结果：低NLR组的OS和PFS均高于高NLR组，低PLR组的OS和PFS均高于高PLR组。高NLR和腹膜转移是OS的独立危险因素。高NLR和高PLR是PFS的独立危险因素。结论：NLR与胃癌患者的较差的临床病理特征相关，且是OS、PFS独立预后危险因素。此外，PLR是PFS的独立危险因素。

Abstract: Objective: The purpose of this study was to evaluate the significance of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on the prognosis of metastatic gastric cancer (GC). This was a retrospective review of 110 patients were at presentation diagnosed with stage IV metastatic GC and all patients received palliative chemotherapy between January 2012 and January 2016 at the Affiliated Hospital of Qingdao University. Pretreatment NLR and PLR, as well as clinicopathological characteristics were collected. Patients were divided into high and low groups according to the cutoff values for NLR and PLR. The Kaplan-Meier method was applied to estimate the overall survival (OS) and progress free survival (PFS) the Cox proportional hazards model to evaluate the related risk factors for OS. All tests were 2-tailed and a P < 0.05 was considered to indicate a statistically significant difference. Results: Patients with high NLR and high PLR had poor overall survival compared with those who had low NLR and low PLR. Our multivariate analysis had indicated that high NLR and peritoneal metastasis was independent prognostic factors for overall survival; however, the PLR was not shown to be an independent prognostic factor. Conclusions: NLR is related to the poor clinicopathological characteristics of gastric cancer patients, and is an independent prognostic risk factor for OS and PFS. PLR is an independent risk factor for PFS.