固载化FeCl3催化合成螺环苯并吡喃[2,3-b]吲哚类衍生物
Synthesis of Spirooxindole-Chromeno[2,3-b]Indole Derivatives Promoted by Immobilized Solid Lewis Acid Catalyst FeCl3
DOI: 10.12677/JOCR.2020.82002, PDF,   
作者: 刘雪松, 于顺明*：上海庚彩新材料科技有限公司，鞍山七彩化学股份有限公司上海研发中心，上海
关键词: 路易斯酸；固载催化剂；三氯化铁；螺环苯并吡喃[2；3-b]吲哚；多组分串联反应；Lewis Acid； Immobilized Solid Catalyst； PS-FeCl3； Spirooxindole-Chromeno[2；3-b]Indole； Multi-Component Reaction
摘要: 高分子固载Lewis酸催化剂相比传统Lewis酸催化剂，在基本保留其原有催化活性、反应条件更温和等特点的同时，还具有对设备低腐蚀性、易于实现连续化、环境友好等显著优点，因而在医药化工领域具有十分广阔的产业化应用前景。本文利用一种固载FeCl3催化剂，即将FeCl3与聚苯乙烯反应制成负载型氯化铁催化剂(PS-FeCl3)，催化靛红、苯酚以及2-卤代吲哚化合物的多组分串联环化反应“一锅法”高效合成螺环苯并吡喃[2,3-b]吲哚类衍生物。
Abstract: Polymer-supported Lewis acid catalysts is dominion over traditional ones in a number of aspects for instance; it retains its original catalytic activity, mild reaction conditions are required, which integrate remarkable advantages in catalyst regeneration, low corrosiveness of equipment, easy achievement of continuous production, environment-friendly aspects, etc. since there are great prospects of wide range of applications in the pharmaceutical and fine chemical industry. In this work, an immobilized solid Lewis acid catalyst (PS-FeCl3) was prepared, which catalyzed the multi-component reaction casecade of isatin, phenol and 2-haloindole in one-pot manner to provide diverse spirooxindole-chromeno[2,3-b]indole derivatives with high efficiency.
文章引用：刘雪松, 于顺明. 固载化FeCl3催化合成螺环苯并吡喃[2,3-b]吲哚类衍生物[J]. 有机化学研究, 2020, 8(2): 15-23. https://doi.org/10.12677/JOCR.2020.82002

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