Cronkhite-Canada综合征1例及文献复习
Cronkhite-Canada Syndrome: A Case Report and Review of the Literature
DOI: 10.12677/ACM.2020.107216, PDF,  被引量   
作者: 闫柳柳:青岛大学,山东 青岛;韩 迪*, 王少军:青岛大学附属医院,山东 青岛
关键词: Cronkhite-Canada综合征腹泻色素沉着营养不良息肉Cronkhite-Canada Syndrome Diarrhea Skin Pigmentation Malnutrition Polyps
摘要: Cronkhite-Canada综合征(Cronkhite-Canada Syndrome, CCS),又称息肉–色素沉着–脱发–爪甲营养不良综合征,因临床极为罕见而容易误诊和漏诊。CCS的病因和发病机制尚不明确,其主要临床表现包括胃肠道多发息肉、色素沉着、脱发、腹泻、营养不良。本文报道CCS患者1例并结合国内外文献进行讨论,旨在为临床上CCS的诊断和治疗提供参考。
Abstract: Cronkhite-Canada syndrome (CCS) is easy to be misdiagnosed and missed for clinical rarity, which is characterized by diarrhea, alopecia, skin pigmentation, malnutrition and gastrointestinal polyps. The etiology and pathogenesis of CCS are not clear. Its main clinical manifestations include multiple gastrointestinal polyps, pigmentation, alopecia, diarrhea, malnutrition. This paper reports a case of CCS and discusses it in combination with the domestic and foreign literature in order to provide a reference for the diagnosis and treatment of CCS in clinic.
文章引用:闫柳柳, 韩迪, 王少军. Cronkhite-Canada综合征1例及文献复习[J]. 临床医学进展, 2020, 10(7): 1437-1441. https://doi.org/10.12677/ACM.2020.107216

参考文献

[1] Gardner, E.J., Burt, R.W. and Freston, J.W. (1980) Gastrointestinal Polyposis: Syndromes and Genetic Mechanisms. Western Journal of Medicine, 132, 488-499.
[2] Cronkhite, L.W. and Canada, W.J. (1955) Generalized Gastrointestinal Polyposis: An Unusual Syndrome of Polyposis, Pigmentation, Alopecia and Onychotrophia. The New England Journal of Medicine, 252, 1011-1015. [Google Scholar] [CrossRef
[3] Choi, Y.J., et al. (2013) Vitiligo: An Unusual Finding in Cronkhite-Canada Syndrome. The Journal of Dermatology, 40, 848-849. [Google Scholar] [CrossRef] [PubMed]
[4] Goto, A. (1995) Cronkhite-Canada Syndrome: Epidemiological Study of 110 Cases Reported in Japan. Nippon Geka Hokan, 64, 3-14.
[5] Rubio, C.A. and Bjork, J. (2016) Cronkhite-Canada syndrome—A Case Report. Anticancer Research, 36, 4215-4217.
[6] Watanabe, C., et al. (2016) Endoscopic and Clinical Evaluation of Treatment and Prognosis of Cronkhite-Canada Syndrome: A Japanese Nationwide Survey. Journal of Gastroenterology, 51, 327-336. [Google Scholar] [CrossRef] [PubMed]
[7] Ward, E.M. and Wolfsen, H.C. (2003) Pharmacological Management of Cronkhite-Canada Syndrome. Expert Opinion on Pharmacotherapy, 4, 385-389. [Google Scholar] [CrossRef] [PubMed]
[8] Sweetser, S., Alexander, G.L. and Boardman, L.A. (2010) A Case of Cronkhite-Canada Syndrome Presenting with Adenomatous and Inflammatory Colon Polyps. Nature Reviews Gastroenterology & Hepatology, 7, 460-464. [Google Scholar] [CrossRef] [PubMed]
[9] Sweetser, S., et al. (2012) Clinicopathologic Features and Treatment Outcomes in Cronkhite-Canada Syndrome: Support for Autoimmunity. Digestive Diseases and Sciences, 57, 496-502. [Google Scholar] [CrossRef] [PubMed]
[10] Daniel, E.S., et al. (1982) The Cronkhite-Canada Syndrome. An Analysis of Clinical and Pathologic Features and Therapy in 55 Patients. Medicine (Baltimore), 61, 293-309. [Google Scholar] [CrossRef
[11] Hsu, Y.Q. and Loke, S.L. (2003) Cronkhite Canada Syndrome. Gastrointestinal Endoscopy, 57, 917. [Google Scholar] [CrossRef
[12] Slavik, T. and Montgomery, E.A. (2014) Cronkhite-Canada Syndrome Six Decades on: The Many Faces of an Enigmatic Disease. Journal of Clinical Pathology, 67, 891-897. [Google Scholar] [CrossRef] [PubMed]
[13] Peart, A.G., et al. (1984) Spontaneous Improvement of Cronkhite-Canada Syndrome in a Postpartum Female. Digestive Diseases and Sciences, 29, 470-474. [Google Scholar] [CrossRef
[14] 张帆, 等. Cronkhite-Canada综合征1例[J]. 中国老年学杂志, 2014(10): 2876-2877.
[15] Yamakawa, K., et al. (2016) Effectiveness of Cyclosporine as a Treatment for Steroid-Resistant Cronkhite-Canada Syndrome: Two Case Reports. BMC Gastroenterology, 16, 123. [Google Scholar] [CrossRef] [PubMed]
[16] Kato, K., et al. (2013) Spontaneous Regression of Polyposis Following Abdominal Colectomy and Helicobacter pylori Eradication for Cronkhite-Canada Syndrome. Case Reports in Gastroenterology, 7, 140-146. [Google Scholar] [CrossRef] [PubMed]
[17] Brosens, L.A., et al. (2016) Pathology and Genetics of Syndromic Gastric Polyps. International Journal of Surgical Pathology, 24, 185-199. [Google Scholar] [CrossRef] [PubMed]
[18] Blonski, W.C., et al. (2005) A Case of Cronkhite-Canada Syndrome with Taste Disturbance as a Leading Complaint. Digestion, 71, 201-205. [Google Scholar] [CrossRef] [PubMed]
[19] 陆小锋, 等. Cronkhite-Canada综合征合并甲状腺功能减退一例[J]. 中华消化杂志, 2015(11): 775.
[20] Cao, X.C., et al. (2007) Clinical Characteristics of Cronkhite-Canada Syndrome in Chinese: Meta-Analysis of 35 Cases. Chinese Medical Journal, 87, 3130-3132.
[21] 姜娜, 等. Cronkhite-Canada综合征1例[J]. 世界华人消化杂志, 2018, 26(28): 1672-1676.
[22] Cho, W., et al. (2018) Cronkhite-Canada Syndrome Showing Good Early Response to Steroid Treatment. Korean Journal of Gastroenterology, 71, 239-243. [Google Scholar] [CrossRef] [PubMed]
[23] Schulte, S., et al. (2019) Case Report of Patient with a Cronkhite-Canada Syndrome: Sustained Remission after Treatment with Corticosteroids and Mesalazine. BMC Gastroenterology, 19, 36. [Google Scholar] [CrossRef] [PubMed]
[24] Ohmiya, N., et al. (2014) Steroid-Resistant Cronkhite-Canada Syndrome Successfully Treated by Cyclosporine and Azathioprine. Journal of Clinical Gastroenterology, 48, 463-464. [Google Scholar] [CrossRef