植物内生菌次生代谢产物研究进展
Research Progress on the Secondary Metabolites of Endophytes
DOI: 10.12677/PI.2020.94023, PDF,    科研立项经费支持
作者: 李千喜:浙江中医药大学生命科学学院,浙江 杭州;周芳美:浙江中医药大学医学技术学院,浙江 杭州;丁志山*:浙江中医药大学,浙江 杭州
关键词: 植物内生菌次生代谢产物生物活性Endophytes Secondary Metabolites Biological Activity
摘要: 植物内生菌普遍存在于植物组织和器官中,种类繁多,资源丰富,分布广泛,且具有多样的生物活性,其次生代谢产物更具有抑菌、抗肿瘤、抗氧化、抗炎等多种作用,可广泛应用于农业、医疗、卫生等领域。植物内生菌次生代谢产物来源广泛且开发潜力巨大,已成为近年来的研究热点之一。本文就以近年来内生菌次生代谢产物的作用方面加以综述,对植物内生菌未来研究的发展趋势做出展望,以期为植物内生菌资源的进一步开发利用提供理论基础。
Abstract: Endophytic fungi are ubiquitous in plant tissues and organs. They are various, abundant in resources, widely distributed and have various biological activities, and their secondary metabolites often have bacteriostatic effect, anti-tumor, anti-oxidationt, anti-inflammatory and so on. Their secondary metabolites can be widely used in agriculture, medical treatment, health and other fields. The secondary metabolites of endophyte have been one of the research hotspots in recent years because of their wide source and great potential. In this paper, the role of the secondary metabolites of endophytes in recent years is reviewed, and the future research trend of endophytes is pro-spected, in order to provide theoretical basis for the further development and utilization of endo-phyte resources.
文章引用:李千喜, 周芳美, 丁志山. 植物内生菌次生代谢产物研究进展[J]. 药物资讯, 2020, 9(4): 156-161. https://doi.org/10.12677/PI.2020.94023

参考文献

[1] 杨志军. 甘草内生菌代谢产物的药效学及相关物质研究[D]: [博士学位论文]. 兰州: 甘肃中医药大学, 2017.
[2] 靳锦, 赵庆, 张晓梅, 等. 植物内生菌活性代谢产物最新研究进展[J]. 微生物学杂志, 2018, 38(3): 103-113.
[3] 周皓, 杨亚滨, 黎唯, 等. 植物内生菌中生物碱成分研究进展[J]. 云南民族大学学报(自然科学版), 2015, 24(1): 1-9.
[4] Catalina, F.P.H., Parichat, S., Matthias, U.K., et al. (2017) OSMAC Approach Leads to New Fusarielin Me-tabolites from Fusarium tricinctum. The Journal of Antibiotics, 70, 726-732. [Google Scholar] [CrossRef] [PubMed]
[5] Sun, W.J., Zhu, H.T., Zhang, T.Y., et al. (2018) Two New Alkaloids from Fusarium tricinctum SYPF 7082, an Endophyte from the Root of Panax notoginseng. Natural Products and Bio-prospecting, 8, 391-396. [Google Scholar] [CrossRef] [PubMed]
[6] 张会, 石绵绵, 李伟, 等. 闽浙马尾杉内生真菌Hypoxylon in-vestiens NX9的次级代谢产物与乙酰胆碱酯酶抑制活性[J]. 福建师范大学学报(自然科学版), 2019, 35(5): 55-60.
[7] Liu, H.X., Tan, H.B., Liu, Y., et al. (2017) Three New Highly-Oxygenated Metabolites from the Endo-phytic Fungus Cytospora rhizophorae A761. Fitoterapia, 117, 1-5. [Google Scholar] [CrossRef] [PubMed]
[8] 吴招娣. 药用植物青灰叶下珠及其内生真菌Aspergillus micronesiensis次级代谢产物的研究[D]: [博士学位论文]. 武汉: 华中科技大学, 2019.
[9] 陈陆敏, 朱力, 刘琴, 等. 白茅内生菌Chaetomium globosum WQ来源的细胞松弛素类化合物研究[J]. 扬州大学学报(农业与生命科学版), 2019, 40(3): 101-106.
[10] 王新位, 郭文强, 赵建元, 等. 刺五加内生放线菌Streptomyces sp. CWJ-256次生代谢产物研究[J]. 中国医药生物技术, 2018, 13(5): 404-411.
[11] Xiao, J., Hu, J.Y., Sun, H.D., et al. (2018) Sinopestalotiollides A-D, Cytotoxic Diphenyl Ether Deriva-tives from Plant Endophytic Fungus Pestalotiopsis palmarum. Bioorganic & Medicinal Chemistry Letters, 28, 515-518. [Google Scholar] [CrossRef] [PubMed]
[12] 卢丹丹, 郑鼎玉, 陈婕, 等. 北桑寄生内生真菌的分离及其次级代谢产物分析[J]. 天然产物研究与开发, 2020, 32(3): 447-452.
[13] Singh, B.N., Upreti, D.K. and Gupta, V.K. (2017) Endolichenic Fungi: Ahidden Reservoir of Next Generation Biopharmaceuticals. Trends in Biotechnology, 35, 808-813. [Google Scholar] [CrossRef] [PubMed]
[14] Singh, A.K., Sharma, R.K., Sharma, V., et al. (2017) Isolation, Morphological Identification and Invitroan Tibacterial Activity of Endophytic Bacteria Isolated from Aza-dirachta indica (neem) Leaves. Veterinary World, 10, 510-516. [Google Scholar] [CrossRef] [PubMed]
[15] 庄礼珂, 马静峰, 何勇. 蜈蚣草内生菌分离筛选及发酵液的抑菌活性[J]. 贵州农业科学, 2018, 46(11): 49-52.
[16] 武利勤, 尚宏忠, 顾海科. 拮抗匍枝根霉的生防菌R1B的筛选鉴定和抑菌活性分析[J]. 生物技术通报, 2019, 35(4): 29-35.
[17] 杨瑞先, 刘萍, 彭彪彪, 等. 药用牡丹根部内生细菌的抑菌活性研究[J]. 北方园艺, 2018(23): 44-52.
[18] 赵玉瑛, 黄之镨, 张琼, 等. 剑叶龙血树内生真菌的分离及体外抑菌活性筛选[J/OL]. 广西植物, 1-14.
[19] 刘美琼. 北部湾海域真菌体外抗肿瘤活性及互隔交链孢菌化学成分研究[D]: [硕士学位论文]. 南宁: 广西医科大学, 2019.
[20] Palanichamy, P., Kannan, S., Murugan, D., et al. (2019) Purification, Crystallization and Anticancer Activity Evaluation of the Compound Alternariol Methyl Ether from Endophytic Fungi Alternaria alternata. Journal of Applied Microbiology, 127, 1468-1478. [Google Scholar] [CrossRef] [PubMed]
[21] Rufin, M.K.T. and Fabrice, F.B. (2019) Endophytic Fungi from Terminalia Species: A Comprehensive Review. Journal of Fungi, 5, 43. [Google Scholar] [CrossRef] [PubMed]
[22] 张小君. 植物内生菌来源的天然产物体外抗肿瘤活性研究[D]: [硕士学位论文]. 扬州: 扬州大学, 2014.
[23] Su, X.Z., Zhu, Y.Y., Tang, J.W., et al. (2020) Pestaloamides A and B, Two Spiro-Heterocyclic Alkaloid Epimers from the Plant Endo-phytic Fungus Pestalotiopsis sp. HS30. Science China Chemistry, 1-6. [Google Scholar] [CrossRef
[24] 张举成. 七株植物内生菌的次生代谢产物及活性研究[D]: [博士学位论文]. 昆明: 云南大学, 2016.
[25] Li, Q., Zhang, Y., Shi, J.L., et al. (2017) Mechanism and Anticancer Ac-tivity of the Metabolites of an Endophytic Fungi from Eucommia ulmoides Oliv. Anti Cancer Agents in Medicinal Chem-istry, 17, 982-989. [Google Scholar] [CrossRef] [PubMed]
[26] 潘峰, 侯凯, 刘云, 等. 植物内生真菌产多糖类天然产物研究进展[J/OL]. 生物技术通报, 1-12[2020-05-24].
[27] Xiong, Y.W., Ju, X.Y., Li, X.W., et al. (2020) Fer-mentation Conditions Optimization, Purification, and Antioxidant Activity of Exopolysaccharides Obtained from the Plant Growth-Promoting Endophytic Actinobacterium Glutamicibacter halophytocola KLBMP 5180. International Journal of Biological Macromolecules, 153, 1176-1185. [Google Scholar] [CrossRef] [PubMed]
[28] 张莹. 香樟内生菌代谢产物的生物活性研究[D]: [硕士学位论文]. 上海: 上海师范大学, 2018.
[29] 杜晓宁. 宁夏枸杞可培养内生菌的多样性及其生物活性研究[D]: [硕士学位论文]. 银川: 宁夏大学, 2016.
[30] Raheleh, S.T., Thoms, R. and Angela, S. (2015) Transcriptome Profiling of the Endophyte Burk Holderiaphy to Firmans PsJN Indicates Sensing of the Plant Environment and Drought Stress. MBio, 6, 621-615. [Google Scholar] [CrossRef
[31] 刘俊, 张青艳, 杨馨, 等. 头花蓼内生真菌Aspergillus terreus油脂类代谢物的鉴定及其抗多药耐药菌和抗炎作用研究[J]. 中国药房, 2018, 29(11): 1483-1487.
[32] Qiu, Z.M., Li, P., Chen, J., et al. (2018) Anti-Inflammatory Polyketides from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L. Tetrahedron, 74, 746-751. [Google Scholar] [CrossRef
[33] Antoine, V., Cédric, T., Anthony, A.A., et al. (2019) Astin C Production by the Endophytic Fungus Cyanodermella Asteris in Planktonic and Immobilized Culture Conditions. Biotechnology Journal, 14, e1800624. [Google Scholar] [CrossRef] [PubMed]
[34] 董金香. 甘肃野生与栽培甘草内生菌有效菌株发酵物与宿主抗炎作用的对比研究[D]: [硕士学位论文]. 兰州: 甘肃中医药大学, 2016.
[35] 杨镇, 曹君. 植物内生菌及其次级代谢产物的研究进展[J]. 微生物学杂志, 2016, 36(4): 1-6.
[36] 于飞. 碱蓬内生真菌JP4-1的筛选、鉴定及促生活性研究[D]: [硕士学位论文]. 沈阳: 沈阳师范大学, 2016.
[37] Abdul, A.E., Salim, B., Intikhab, A., et al. (2020) Com-plete Genome Sequence of Paenibacillus sp. JZ16, a Plant Growth Promoting Root Endophytic Bacterium of the Desert Halophyte Zygophyllum Simplex. Current Microbiology, 77, 1097-1103. [Google Scholar] [CrossRef] [PubMed]
[38] 孙艺昕, 门兴元, 李超, 等. 高抗虫玉米内生真菌对玉米蚜生长、繁殖及取食选择的影响[J]. 中国生物防治学报, 2020, 36(2): 184-188.
[39] 谭改秀. 三株药用植物内生菌次级代谢产物及其功能的研究[D]: [硕士学位论文]. 开封: 河南大学, 2018.
[40] Zhang, Q., Gao, B.L., Xiao, Y.W., et al. (2020) Purification and Characterization of a Novel β-Glucuronidase Precisely Converts Glycyrrhizin to Glycyrrhetinic Acid 3-O-mono-β-D-Glucuronide from Plant Endophytic Chaetomium globosum DX-THS3. Interna-tional Journal of Biological Macromolecules, 159, 782-792. [Google Scholar] [CrossRef] [PubMed]