苦瓜降糖活性成分与作用机制
Hypoglycemic Active Components and Mechanism of Bitter Gourd
DOI: 10.12677/PI.2020.95024, PDF,    国家自然科学基金支持
作者: 刘子记：中国热带农业科学院热带作物品种资源研究所，海南 海口;海南省热带园艺作物品质调控重点实验室，海南 海口；田丽波：海南省热带园艺作物品质调控重点实验室，海南 海口；牛 玉, 于仁波, 杨 衍*：中国热带农业科学院热带作物品种资源研究所，海南 海口
关键词: 苦瓜；皂苷；降糖作用；类胰岛素；Bitter Gourd； Saponin； Hypoglycemic Effect； Insulin-Like
摘要: 苦瓜作为一种药食同源植物，具有丰富的营养价值和药用价值。本文总结了苦瓜降糖活性成分和降糖作用机理，以期为苦瓜的开发利用提供参考。
Abstract: Bitter gourd, as a medicinal and edible plant, has rich nutritional and medicinal value. This paper had summarized the hypoglycemic active components and hypoglycemic mechanism of bitter gourd, which could provide reference for the development and utilization of bitter gourd.
文章引用：刘子记, 田丽波, 牛玉, 于仁波, 杨衍. 苦瓜降糖活性成分与作用机制[J]. 药物资讯, 2020, 9(5): 163-167. https://doi.org/10.12677/PI.2020.95024

参考文献

[1] Zhang, C.Z., Fang, E.F., Zhang, H.T., Liu, L.L. and Yun, J.P. (2015) Momordica Charantia Lectin Exhibits Antitumor Activity towards Hepatocellular Carcinoma. Investigational New Drugs, 33, 1-11. [Google Scholar] [CrossRef] [PubMed]
[2] Yang, S.J., Choi, J.M., Park, S.E., Rhee, E.J., Lee, W.Y., Oh, K.W., Park, S.W. and Park, C.Y. (2015) Preventive Effects of Bitter Melon (Momordica charantia) against Insulin Re-sistance and Diabetes Are Associated with the Inhibition of NF-κB and JNK Pathways in High-Fat-Fed OLETF Rats. The Journal of Nutritional Biochemistry, 26, 234-240. [Google Scholar] [CrossRef] [PubMed]
[3] Liaw, C.C., Huang, H.C., Hsiao, P.C., Zhang, L.J., Lin, Z.H., Hwang, S.Y., Hsu, F.L. and Kuo, Y.H. (2015) 5β, 19-Epoxycucurbitane Triterpenoids from Momordica charantia and Their Anti-Inflammatory and Cytotoxic Activity. Planta Medica, 81, 62-70. [Google Scholar] [CrossRef] [PubMed]
[4] Panda, B.C., Mondal, S., Devi, K.S., Maiti, T.K., Khatua, S., Acharya, K. and Islam, S.S. (2015) Pectic Polysaccharide from the Green Fruits of Momordica charantia (Karela): Structural Characterization and Study of Immunoenhancing and Antioxidant Properties. Carbohydrate Research, 401, 24-31. [Google Scholar] [CrossRef] [PubMed]
[5] Zhang, L.J., Liaw, C.C., Hsiao, P.C., et al. (2014) Cucurbi-tane-Type Glycosides from the Fruits of Momordica charantia and Their Hypoglycaemic and Cytotoxic Activities. Journal of Functional Foods, 6, 564-574. [Google Scholar] [CrossRef] 
[6] Hsiao, P.C., Liaw, C.C., Hwang, S.Y., et al. (2013) Antiproliferative and Hypoglycemic Cucurbitane-Type Glycosides from the Fruits of Momordica charantia. Journal of Agriculture and Food Chemistry, 61, 2979-2986. [Google Scholar] [CrossRef] [PubMed]
[7] 柴瑞华, 肖春莹, 关健, 等. 苦瓜总皂苷降血糖作用的研究[J]. 中草药, 2008, 39(5): 746-751.
[8] 关悦, 李扬. 苦瓜总皂苷对2型糖尿病大鼠肾保护作用及其机制研究[J]. 中国食物与营养, 2012, 18(9): 73-75.
[9] 马春宇, 于洪宇, 王慧娇, 等. 苦瓜总皂苷对2型糖尿病大鼠血脂和脂肪因子的研究[J]. 中药药理与临床, 2013, 29(5): 56-59.
[10] Iseli, T.J., Turner, N., Zeng, X., et al. (2013) Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKK β. PLoS ONE, 8, e62309. [Google Scholar] [CrossRef] [PubMed]
[11] 关悦, 李扬, 王云枫. 苦瓜总皂苷对2型糖尿病大鼠胰岛素原基因表达的影响[J]. 中国食物与营养, 2013, 19(5): 65-67.
[12] Li, J.L., Wang, Y.Q., Huang, J., et al. (2010) Characterization of Antioxidant Polysaccharides in Bitter Gourd (Momordica charantia L.) Cultivars. Journal of Food Agriculture and Environment, 4, 2189-2193.
[13] 陈红漫, 李寒雪, 阚国仕, 等. 苦瓜多糖的抗氧化活性与降血糖作用相关性研究[J]. 食品工业科技, 2012, 33(18): 349-354.
[14] 董英, 张慧慧. 苦瓜多糖降血糖活性成分的研究[J]. 营养学报, 2008, 30(1): 54-56.
[15] 宋金平. 苦瓜多糖对糖尿病小鼠的降血糖作用和胰岛素水平的影响[J]. 中国实用医药, 2012, 7(3): 250-251.
[16] Yuan, X., Gu, X. and Tang, J. (2008) Purification and Characterization of a Hypoglycemic Peptide from Momordica charantia L. var. Abbreviate Ser. Food Chemistry, 111, 415-420. [Google Scholar] [CrossRef] [PubMed]
[17] Rajasekhar, M.D., Badri, K.R., Kumar, K.V., et al. (2010) Isolation and Characterization of a Novel Antihyperglycemic Protein from the Fruits of Momordica cymbalaria. Journal of Ethnopharmacology, 128, 58-62. [Google Scholar] [CrossRef] [PubMed]
[18] Lo, H., Ho, T., Lin, C., et al. (2013) Momordica charantia and Its Novel Polypeptide Regulate Glucose Homeostasis in Mice via Binding to Insulin Receptor. Journal of Agricultural and Food Chemistry, 63, 2461-2468. [Google Scholar] [CrossRef] [PubMed]
[19] Ahmad, Z., Zamhuri, K.F., Yaacob, A., et al. (2012) In Vitro Anti-Diabetic Activities and Chemical Analysis of Polyepetide-k and Oil Isolated from Seeds of Momordica charantia (Bitter Gourd). Molecules, 17, 9631-9640. [Google Scholar] [CrossRef] [PubMed]
[20] Mohamed, S. (2014) Functional Foods against Metabolic Syn-drome (Obesity, Diabetes, Hypertension and Dyslipidemia) and Cardiovascular Disease. Trends in Food Science and Technology, 35, 114-128. [Google Scholar] [CrossRef] 
[21] Fang, E.F. and Ng, T.B. (2011) Bitter Gourd (Momordica charantia) Is a Cornucopia of Health: A Review of Its Credited Antidiabetic, Anti-HIV, and Antitumor Properties. Current Molec-ular Medicine, 11, 417-436. [Google Scholar] [CrossRef] [PubMed]
[22] Cummings, E., Hundal, H.S. and Wackerhage, H. (2004) Momordica charantia Fruit Juice Stimulates Glucose and Amino Acid Uptakes in L6 Myotubes. Molecular and Cellular Biochemistry, 261, 99. [Google Scholar] [CrossRef] 
[23] Matsuur, H., Asakawa, C. and Kurimoto, M. (2002) Alpha-Glucosidase Inhibitor from the Seeds of Balsam Pear (Momordica charantia) and the Fruit Bodies of Grifola frondosa. Bioscience, Biotechnology, and Biochemistry, 66, 1576. [Google Scholar] [CrossRef] [PubMed]
[24] Mahomoodally, M.F., Fakim, A.G. and Subratty, A.H. (2004) Momor-dica charantia Extracts Inhibit Uptake of Monosaccharide and Amino Acid across Rat Everted Gutacs In-Vitro. Biologi-cal and Pharmaceutical Bulletin, 27, 216. [Google Scholar] [CrossRef] [PubMed]
[25] Sitasawad, S.L., Shewade, Y. and Bhonde, R. (2000) Role of Bitter Gourd Fruit Juice in STZ-Induced Diabetic State in Vivo and In Vitro. Journal of Ethnopharmacology, 73, 71. [Google Scholar] [CrossRef] 
[26] Raza, H., Ahmed, I. and John, A. (2004) Tissue Specific Expression and Immunohisto Chemical Localization of Glutathione S-Transferase in Streptozotocin Induced Diabetic Rats: Modulation by Momordica charantia (Karela) Extract. Life Sciences, 74, 1503-1511. [Google Scholar] [CrossRef] [PubMed]
[27] Sathishsekar, D. and Subramanian, S. (2005) Beneficial Effects of Momordica charantia Seeds in the Treatment of STZ-Induced Diabetes in Experimental Rats. Biological and Pharma-ceutical Bulletin, 28, 978-983. [Google Scholar] [CrossRef] [PubMed]
[28] Grover, J.K., Vats, V. and Rathi, S.S. (2001) Traditional Indian Antidia-betic Plants Attenuate Progression of Renal Damage in Streptozotocin Induced Diabetic Mice. Ethnopharmacology, 76, 233. [Google Scholar] [CrossRef] 
[29] Rathi, S.S., Grover, J.K. and Vikrant, V. (2002) Prevention of Experimental Diabetic Cataract by Indian Ayurvedic Plant Extracts. Phytotherapy Research, 16, 774. [Google Scholar] [CrossRef] [PubMed]