青光眼房水流动的数值模拟分析

Numerical Simulation of Aqueous Humor Flow in Glaucoma

摘要: 重建青光眼眼球三维模型，探究不同程度瞳孔阻滞和小梁网病变对前后房房水流动的影响。基于超声生物显微镜影像，进行人眼眼球三维建模，采用环形通道模化虹膜–晶状体间隙以及小梁网结构，将环形通道分别划分为20和32等分，通过闭合不同数量的等分来表明瞳孔阻滞程度以及小梁网病变程度，应用有限体积法开展房水流动的数值模拟。结果表明，前后房压差与虹膜–晶状体间隙的开度呈指数关系；此外，前房压力与小梁网的开度也呈指数关系，但小梁网闭合程度对前后房压差影响不大。研究结果有助于青光眼患者瞳孔阻滞以及小梁网病变程度的预测，对青光眼患者病情分析具有借鉴意义。

Abstract: Objective: To reconstruct the three-dimensional model of glaucoma eyeball and explore the in-fluence of different degrees of pupillary block and trabecular meshwork lesion on anterior and posterior chamber aqueous humor flow. Based on ultrasound biomicroscopy (UBM), the three-dimensional modeling of human eyeball was carried out. The iris-lens space and trabecular meshwork structure were modeled by annular channel. The annular channel was divided into 20 and 32 equal parts respectively. The degree of pupillary block and the degree of trabecular meshwork lesions were indicated by closing different numbers of bisections. The finite volume method was used to simulate the aqueous humor flow. The results showed that there was an ex-ponential relationship between the anterior and posterior chamber pressure difference and the opening of iris-lens space; in addition, the relationship between anterior chamber pressure and the opening of trabecular meshwork was also exponential, but the closure of trabecular meshwork had little effect on the pressure difference between anterior and posterior chamber. The results of this study are helpful to predict the degree of pupillary block and trabecular meshwork lesions in glaucoma patients, and it has reference significance for the disease analysis of glaucoma patients.