定量磁共振成像在关节软骨中的应用研究进展
Research Progress of Quantitative Magnetic Resonance Imaging in Articular Cartilage
摘要: 在临床上，关节软骨损伤是一种常见病，其发生发展可由外伤、骨性关节炎(osteoarthritis, OA)以及剥脱性骨软骨炎等原因造成，而且这种损坏发生后很难修复。关节软骨损伤主要表现为关节疼痛及功能障碍，关节软骨的损伤以及退变都不同程度地发生在老年人及长期剧烈运动的人群中。关节镜检查被认为是诊断关节软骨病变的金标准。但由于其有创检查的性质，对检查者的技术水平要求很高，且无法深入了解软骨的内部情况。定量磁共振成像(quantitative magnetic resonance imaging, qMRI)既可显示软骨形态学变化，又可以定量评估软骨的生化成分，由于该技术具有无创、良好的软组织分辨力、多参数、多平面成像的优势，它能以非侵入性的定量测量来敏感地监测软骨的微细变化，提供可靠和可重复的成像生物标志物。
Abstract: Clinically, articular cartilage damage is a common disease. Its occurrence and development can be caused by factors such as trauma, osteoarthritis (OA), and osteochondritis dissecans. Once this damage occurs, it is difficult to repair. Articular cartilage damage is mainly manifested as joint pain and dysfunction. In the elderly and people who exercise vigorously for a long time, the degeneration and damage of articular cartilage occur to varying degrees. Arthroscopy is considered to be the gold standard for diagnosing articular cartilage diseases. However, it is an invasive examination, which requires a high level of technology for the examiner, and cannot have a thorough understanding of the internal condition of the cartilage. Quantitative magnetic resonance imaging (qMRI) can not only display cartilage morphological changes, but also quantitatively evaluate the biochemical components of cartilage. It has the advantages of non-invasive, good soft tissue resolution, multi-parameter, and multi-plane imaging. It can sensitively monitor the microscopic changes of cartilage with non-invasive quantitative measurements and provide reliable and repeatable imaging biomarkers.
文章引用：薛源, 王拯, 杨绿林, 冯罡宁, 胡学宇, 金群华. 定量磁共振成像在关节软骨中的应用研究进展[J]. 临床医学进展, 2020, 10(8): 1855-1861. https://doi.org/10.12677/ACM.2020.108279

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