妊娠哺乳相关骨质疏松症发病机制探讨

Discussion on the Pathogenesis of Pregnancy and Lactation-Associated Osteoporosis

摘要: 妊娠和哺乳使母体代谢产生一系列适应性反应，机体各项指标也会产生相应变化。由于妊娠期妇女血钙降低、尿钙排泄率增加，因此有极少数妇女会在妊娠后期或产后早期出现骨质疏松。妊娠哺乳期骨质疏松的发病原因未明，可能与钙和维生素D缺乏、激素水平变化、低体重、家族史等存在一定联系。因其发生在妊娠哺乳期，一旦因骨质疏松继发骨折，可严重降低孕产妇的生活质量，对其产生重大影响。现就妊娠哺乳相关骨质疏松症的发生机制进行综述，以便更好地为临床和科研提供依据。

Abstract: Pregnancy and lactation cause a series of adaptive responses to maternal metabolism, the body’s various indicators will also produce corresponding changes. Due to the reduction of blood calcium and the increase of urinary calcium excretion rate in pregnant women, very few women develop osteoporosis late in pregnancy or early postpartum. The cause of pregnancy and lactation-associated osteoporosis is unknown, it may be associated with calcium and vitamin D deficiency, hormonal changes, low body weight, and family history. Because it happens during pregnancy and lactation, once the osteoporosis causes fracture, it can seriously reduce the quality of life of pregnant women. The mechanism and therapeutic drugs of pregnancy-lactation related osteoporosis were reviewed in our article in order to provide a better basis for clinical and scientific research.