微生物群与肿瘤发生相关性的研究进展

Correlation between Microbiota and Oncogenesis: Research Progress

摘要: 正常微生物群与机体形成共生的关系，与机体健康或疾病状态密切相关。尽管机体内微生物群的组成受到年龄、环境、生活方式等因素的影响，但在正常生理情况下处于稳定状态。微生物群可以参与调节机体代谢、炎症反应和免疫应答等生理过程，维持着机体的局部稳态。近年来，越来越多的研究表明，微生物群与肿瘤的发生具有相关性。本文将综述微生物群影响肿瘤发生发展的研究证据，以及其中所涉及的微生物种类，为肿瘤的精准预防及治疗提供依据。

Abstract: The normal microbiota forms a symbiotic relationship with the body, which is closely related to the body’s health or disease state. Although the composition of the microbiota in the body is affected by factors such as age, environment, and lifestyle, it is in a stable state under normal physiological conditions. The microbiota can participate in the regulation of physiological processes such as metabolism, inflammation and immune response, and maintain the body’s local homeostasis. In recent years, more and more studies have shown that the microbiota is related to the occurrence of cancer. This article will review the research evidence that the microbiota affects the occurrence and development of tumors, as well as the types of microorganisms involved, to provide a basis for the precise prevention and treatment of cancer.