上气道阻力综合征病例分析并文献综述

Case Analysis and Literature Review of Upper Airway Resistance Syndrome

摘要: 目的：探讨上气道阻力综合征临床表现及诊治。方法：对深圳市人民医院呼研所睡眠医学中心2019年8月至2020年3月29例诊断为上气道阻力综合征患者进行分析并对上气道阻力综合征——非缺氧性睡眠呼吸紊乱进行文献综述。结果：临床上对睡眠呼吸障碍的认识不足，UARS的诊断经常被忽视。结论：上气道阻力综合征(UARS)和阻塞性睡眠呼吸暂停综合征(OSAS)一样，都是睡眠中的异常呼吸。UARS综合征的定义是为了识别“OSAS”未涵盖的病理，使医护人员更早地认识到疾病的病理，并对睡眠呼吸紊乱(SDB)的发展特征进行研究。SDB随着年龄的增长而演变，最后导致OSA。如何更早地认识到UARS导致阻塞性睡眠呼吸暂停(OSA)的问题，并了解预防其向OSA的发展的措施，这才是最重要的。临床上应加强对非缺氧性睡眠呼吸障碍(NHSDB)的认识。

Abstract: Objective: To investigate the clinical manifestations, diagnosis and treatment of upper airway resistance syndrome. Methods: From August 2019 to March 2020, 29 patients diagnosed as upper airway resistance syndrome were analyzed and literature review was carried out on upper airway resistance syndrome—non-hypoxic sleep disorder of breathing in the Sleep Medical Center of Huyan Institute of Shenzhen People’s Hospital. Results: The clinical understanding of sleep dyspnea is insufficient, and the diagnosis of UARS is often neglected. Conclusion: Upper airway resistance syndrome (UARS) as obstructive sleep apnea syndrome (OSAS) has been described as abnormal breathing during sleep. The definition of UARS syndrome was aimed at recognizing pathology not covered by ‘OSAS’. It was aimed also at pushing specialists to recognize pathologies earlier and to elicit research in the developmental features of sleep-disordered-breathing (SDB). UARS leads to OSAS with aging. However, the real issue is to recognize the problems leading to the co-morbid obstructive sleep apnea (OSA) much earlier, and to understand what can be done to prevent the development of co-morbid OSA. The recognition of non-hypoxic sleep disordered breathing (NHSDB) is a step in this direction.