基质金属蛋白酶和动脉粥样硬化相关性研究进展
Research Progress of Correlation between Matrix Metalloproteinases and Atherosclerosis
DOI: 10.12677/ACM.2020.1010356, PDF,   
作者: 胡扬扬, 李 燕, 陈 鹏*：昆明医科大学药学院暨云南省天然药物药理重点实验室，云南 昆明
关键词: 基质金属蛋白酶；动脉粥样硬化；研究进展；Matrix Metalloproteinases； Atherosclerosis； The Research Progress
摘要: 基质金属蛋白酶(matrix metalloproteinases, MMPs)是一组锌离子和钙离子依赖性的蛋白水解酶，通过降解细胞外基质(extracellular matrix, ECM)、引发炎症反应和调控相关因子，参与动脉粥样硬化的全过程。本文就相关基质金属蛋白酶与动脉粥样硬化的相关性研究进展作一综述。
Abstract: Matrix metalloproteinases (MMPs), a group of zinc ion dependent proteolytic enzymes, participate in the whole process of atherosclerosis by degrading extracellular matrix (ECM), triggering inflammatory response and regulating related factors. In this paper, the effect of matrix metalloproteinases on atherosclerosis was reviewed.
文章引用：胡扬扬, 李燕, 陈鹏. 基质金属蛋白酶和动脉粥样硬化相关性研究进展[J]. 临床医学进展, 2020, 10(10): 2361-2366. https://doi.org/10.12677/ACM.2020.1010356

参考文献

[1] Shi, X., Wei, Y.T., Li, H., et al. (2020) Long Non-Coding RNA H19 in Atherosclerosis: What Role? Molecular Medicine, 26, 72. [Google Scholar] [CrossRef] [PubMed]
[2] 周刚, 于吉星. 冠状动脉病变与颈动脉粥样硬化的相关性分析[J]. 中西医结合心血管病电子杂志, 2019, 7(9): 30-31.
[3] Brown, B.A., Williams, H. and George, S.J. (2017) Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis. Progress in Molecular Biology & Translational Science, 147, 197. [Google Scholar] [CrossRef] [PubMed]
[4] 陈建雅, 钟望涛. 基质金属蛋白酶-9与脑血管动脉粥样硬化的相关性[J]. 神经疾病与精神卫生, 2015(5): 530-532.
[5] 刘明明, 李爱玲, 修瑞娟. 基质金属蛋白酶的研究进展[J]. 中国病理生理杂志, 2018, 34(10): 1914-1920.
[6] 严菲, 孟照辉. 基质金属蛋白酶-1与急性冠状动脉综合征[J]. 临床医学, 2016(8): 126.
[7] Lenglet, S., Thomas, A., Chaurand, P., et al. (2012) Molecular Imaging of Matrix Metalloproteinases in Atherosclerotic Plaques. Thrombosis and Haemostasis, 107, 409-416. [Google Scholar] [CrossRef] 
[8] Xing, Y., Shepherd, N., Lan, J., et al. (2017) MMPs/TIMPs Imbalances in the Peripheral Blood and Cerebrospinal Fluid Are Associated with the Pathogenesis of HIV-1-Associated Neurocognitive Disorders. Brain, Behavior, and Immunity, 65, 161-172. [Google Scholar] [CrossRef] [PubMed]
[9] 宋南, 杨林. 基质金属蛋白酶-2的研究进展[J]. 临床合理用药杂志, 2012, 5(6): 152-153.
[10] 郭俊林, 张立. 基质金属蛋白酶-2与冠状动脉粥样硬化性疾病的研究进展[J]. 医学信息, 2018, 31(4): 27-30.
[11] Chen, X., Qian, S., Hoggatt, A., et al. (2017) Endothelial Cell-Specific Deletion of P2Y2 Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 37, 75-83. [Google Scholar] [CrossRef] 
[12] 马小欣, 彭萍, 徐光泽, 等. 急性冠状动脉综合征患者血浆MMP-2、MMP-9水平变化的临床观察[J]. 心脑血管病防治, 2016, 16(5): 353-355.
[13] 郝星, 龙仙萍, 王正龙, 刘西平, 石蓓, 陈文明. 心外膜脂肪体积及血清基质金属蛋白酶-2与冠状动脉粥样硬化斑块稳定性的关系[J]. 山东医药, 2018, 58(33): 47-49.
[14] 钟丽华, 孙超宇, 曹雪, 李馨, 白秀萍, 李学奇. 急性冠状动脉综合征患者血清基质金属蛋白酶-2检测的临床意义[J]. 中国心血管病研究, 2019, 17(8): 729-731.
[15] 刘聪辉, 戈艳蕾, 朱晓颖, 解宝泉, 付爱双, 王红阳, 李洪力, 张盼盼, 张嘉宾. 血清MCP-1、SAA对于2型糖尿病伴OSAHS患者认知功能损伤的临床意义[J]. 中国老年学杂志, 2019, 39(9): 2096-2098.
[16] Ito, Y., Ishiguro, H., Kobayashi, N., et al. (2015) Adipocyte-Derived Monocyte Chemotactic Protein-1 (MCP-1) Promotes Prostate Cancer Progression through the Induction of MMP-2 Activity. Prostate, 75, 1009-1019. [Google Scholar] [CrossRef] [PubMed]
[17] Woods, A., Brull, D.J., Humphries, S.E., et al. (2000) Genetics of Inflammation and Risk of Coronary Artery Disease: The Central Role of Intcrlcukin-6. European Heart Journal, 21, 1574-1583. [Google Scholar] [CrossRef] [PubMed]
[18] 童辉煜. 基质金属蛋白酶9在动脉粥样硬化中的研究进展[J]. 中国动脉硬化杂志, 2016, 24(8): 855-859.
[19] 安登坤, 梁浩, 宋淑亮, 等. MMPs在动脉粥样硬化中的作用及其抑制剂的研究进展[J]. 生命科学, 2015, 27(10): 1274-1279.
[20] Ma, L., Guan, Y. and Du, Z. (2015) Salvianolic Acid B Down-Regulates Matrix Metalloproteinase-9 Activity and Expression in Tumor Necrosis Factor-α-Induced Human Coronary Artery Endothelial Cells. Chinese Medical Journal, 128, 2658-2663. [Google Scholar] [CrossRef] [PubMed]
[21] Egerai, S., Alessia, N., Marika, M., et al. (2014) Hydroxytyrosol Suppresses MMP-9 and COX-2 Activity and Expression Inactivated Human Monocytes via PKCα and PKCβ1 Inhibition. Atherosclerosis, 232, 17-24. [Google Scholar] [CrossRef] [PubMed]
[22] 杜纪兵, 刘寅, 高静, 等. MMP3基因启动子区多态性与动脉粥样硬化斑块细胞外基质稳定性的相关性[J]. 中华医学遗传学杂志, 2019, 36(6): 645-648.
[23] 陆蕙, 胡东南, 王蓉, 等. 基质金属蛋白酶3基因多态性与老年冠状动脉粥样硬化性心脏病的相关性分析[J]. 临床和实验医学杂志, 2018, 17(11): 1200-1203.
[24] 李永芳, 李艾帆, 张玉超, 等. 基质金属蛋白酶3-1612基因多态性与急性缺血性脑卒中的关系[J]. 中国现代医学杂志, 2018, 28(31): 19-24.
[25] Beton, O., Arslan, S., Acar, B., et al. (2016) Association between MMP-3 and MMP-9 Polymorphisms and Coronary Artery Disease. Biomedical Reports, 5, 709-714. [Google Scholar] [CrossRef] [PubMed]
[26] Flex, A., Gaetani, E., Papaleo, P., et al. (2004) Proinflammatory Genetic Profiles in Subjects with History of Ischemic Stroke. Stroke, 35, 2270-2275. [Google Scholar] [CrossRef] 
[27] 刘爽, 赵冬雪. 基质金属蛋白酶12的研究进展[J]. 医学综述, 2018, 24(14): 2781-2786.
[28] Johnson, J.L., Devel, L., Czarny, B., et al. (2011) A Selective Matrix Metalloproteinase-12 Inhibitor Retards Atherosclerotic Plaque Development in Apo Lipoprotein E-Knockout Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 528-535. [Google Scholar] [CrossRef] 
[29] Kolodgie, F.D., Narula, J., Burke, A.P., Haider, N., Farb, A., Smialek, J., Virmani, R., et al. (2000) Localization of Apoptotic Macrophages at the Site of Plaque Rupture in Sudden Coronary Death. The American Journal of Pathology, 157, 1259-1268. [Google Scholar] [CrossRef] 
[30] 李学会, 苏建芬, 蒋小亚, 等. 经腹三维超声建立正常胎儿小脑蚓部参考值研究[J]. 临床超声医学杂志, 2017, 19(11): 762.
[31] Reddy, R.H., Prashanth, K. and Ajit, M. (2017) Significance of Foetal Transcerebellar Diameter in Foetal Biometry: A Pilot Study. Journal of Clinical and Diagnostic Research, 11, TC01-TC04. [Google Scholar] [CrossRef] 

为你推荐