锥光束乳腺CT与MRI、乳腺X线摄影对乳腺非肿块型病变大小测量的准确性分析

Comparative Analysis of Contrast-Enhanced Cone Beam Breast CT, MRI and Digital Mammography Measuresize of Breast Non-Mass Lesions

摘要: 目的：探讨锥光束乳腺CT (Cone beam breast computed tomography，CBBCT)、MRI及数字化乳腺X线摄影(Digitalmammography，DM)术前测量乳腺非肿块型病变(Non-masslesion, NML)大小的准确性。方法：本研究回顾性分析我院2019年7月至2019年12月期间37例同时行CBBCT、MRI及DM检查提示NML且经病理证实的患者资料，以大体手术病理为金标准，应用Pearson相关分析对三种检查方法测量病变大小与病理标本大小进行对比。结果：CBBCT、MRI、DM所测量病变最大径分别为(4.60 ± 1.70) cm、(4.70 ± 2.12) cm、(5.75 ± 2.33) cm，大体手术标本最大径为(4.50 ± 2.12) cm；三种影像方法所测量病变大小均较病理标本大，三种影像方法与大体病理测量病变大小的相关性系数分别为r = 0.941、0.846、0.609 (P值均<0.001)，其中CBBCT所测量病变大小与大体病理测量病变大小的相关性最高。结论：CBBCT测量NML大小的准确性高于MRI及DM。

Abstract: Objective: To compare the accuracy of contrast enhanced cone beam breast CT (CE-CBBCT), MRI and digital mammography (DM) in the measurement of preoperative tumor sizes of breastnon-mass lesion (NML). Methods: In this retrospective study, the study cohort included 37 patients acquired between July 2019 and December 2019 with histopathologic confirmed NML findings. The patients in the cohort underwent all three modalities (CE-CBBCT, DM, and MRI). The sizes of NML measured from the three imaging modalities were compared using surgical pathology measurements as gold standard. Pearson coefficient was used to analyze the correlation between the sizes measured from images and pathological specimens. Results: The maximum diameters of CBBCT, MRI, DM and pathology specimen were (4.60 ± 1.70) cm, (4.70 ± 2.12) cm, (5.75 ± 2.33) cm and (4.50 ± 2.12) cm, respectively. The sizes of three imaging methods were larger than pathological specimens. The correlation coefficients (r) between the three imaging methods and pathology were 0.941, 0.846 and 0.609, respectively (P < 0.001), CBBCT had the highest correlation with pathology. Conclusion: CE-CBBCT is more accurate than MRI and DM in evaluating the sizes of NML.