慢性心理应激对骨质疏松的影响
Effect of Chronic Psychological Stress on Osteoporosis
DOI: 10.12677/ACM.2020.1010365, PDF,   
作者: 吕汶彩, 许慧宁*:青海大学,青海大学附属医院老年科,青海 西宁
关键词: 慢性心理应激骨质疏松Chronic Psychological Stress Osteoporosis
摘要: 慢性疾病不能自愈也很难治愈,骨质疏松症是一种常见的慢性代谢性骨骼疾病,在我国已被公认为卫生保健方面的挑战,给个人及卫生保健支出带来了负担。当人体处于各种慢性疾病的状态下就会产生心理应激,慢性心理应激产生的重大生化、生理效应通过多种信号传导途径加剧骨质疏松症的进展,慢性心理应激对骨质疏松的影响尚未引起人们的重视,本文旨在叙述慢性心理应激影响骨质疏松症的机制,从而为预防及治疗骨质疏松提供确切依据,以改善骨质疏松对人们生活质量的影响。
Abstract: Chronic diseases cannot be self-healing and difficult to cure. Osteoporosis is a common chronic metabolic bone disease, which has been recognized as a health care challenge in China, and brings a burden to individuals and health care expenditure. When the human body is in the state of various chronic diseases, psychological stress will occur. The major biochemical and physiological effects of chronic psychological stress aggravate the progress of osteoporosis through a variety of signal transduction pathways. The purpose of this article is to describe the mechanism of the effect of chronic psychological stress on osteoporosis, so as to provide a basis for the prevention and treatment of osteoporosis, to reduce the effect of osteoporosis on people’s life quality.
文章引用:吕汶彩, 许慧宁. 慢性心理应激对骨质疏松的影响[J]. 临床医学进展, 2020, 10(10): 2418-2423. https://doi.org/10.12677/ACM.2020.1010365

参考文献

[1] Rossella, C., Federica, B., et al. (2019) Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly. Journal of Clinical Medicine, 8, 1564. [Google Scholar] [CrossRef] [PubMed]
[2] Zhang, Z.P., Zhao, Q.P., Liu, T.J., et al. (2020) Effect of Vicenin-2 on Ovariectomy-Induced Osteoporosis in Rats. Biomedicine & Pharmacotherapy, 129, Article ID: 110474. [Google Scholar] [CrossRef] [PubMed]
[3] Bree, J.C. and Meenakshi, D. (2020) Osteoporosis in Older Adults. Medical Clinics of North America, 104, 873-884. [Google Scholar] [CrossRef] [PubMed]
[4] Qin, H., Lin, Z.J., Vásquez, E., et al. (2019) The Association between Chronic Psychological Stress and Uterine Fibroids Risk: A Meta-Analysis of Observational Studies. Stress Health, 35, 585-594. [Google Scholar] [CrossRef] [PubMed]
[5] Azuma, K., Adachi, Y., Hayashi, H., et al. (2015) Chronic Psychological Stress as a Risk Factor of Osteoporosis. Journal of UOEH, 37, 245-253. [Google Scholar] [CrossRef] [PubMed]
[6] Kelly, R.R., McDonald, L.T., Jensen, N.R., et al. (2019) Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions. Front Psychiatry, 10, 200. [Google Scholar] [CrossRef] [PubMed]
[7] 穆卡达斯·艾尔肯, 徐迎胜. 抑郁症与骨质疏松关系的研究进展[J]. 山东医药, 2020, 60(4): 91-94.
[8] Pervanidou, P. and Chrousos, G.P. (2011) Stress and Obesity/Metabolic Syndrome in Childhood and Adolescence. International Journal of Pediatric Obesity, 6, 21-28. [Google Scholar] [CrossRef] [PubMed]
[9] Chrousos, G.P. and Kino, T. (2009) Glucocorticoid Signaling in the Cell. Expanding Clinical Implications to Complex Human Behavioral and Somatic Disorders. Annals of the New York Academy of Sciences, 1179, 153-166. [Google Scholar] [CrossRef] [PubMed]
[10] Wang, T.T., Liu, X.N. and He, C.Q. (2020) Glucocorticoid-Induced Autophagy and Apoptosis in Bone. Apoptosis, 25, 157-168. [Google Scholar] [CrossRef] [PubMed]
[11] Briot, K. and Roux, C. (2015) Glucocorticoid-Induced Osteoporosis. RMD Open, 1, e000014. [Google Scholar] [CrossRef] [PubMed]
[12] 赫明超, 张勇, 连音, 王拥军, 张岩. 抑郁症和骨质疏松症关系的研究进展[J]. 中国骨质疏松杂志, 2019, 25(4): 550-553.
[13] Haffner-Luntzer, M., Foertsch, S., Fischer, V., et al. (2019) Chronic Psychosocial Stress Compromises the Immune Response and Endochondral Ossification during Bone Fracture Healing via β-AR Signaling. Proceedings of the National Academy of Sciences of the United States of America, 116, 8615-8622. [Google Scholar] [CrossRef] [PubMed]
[14] Liang, H.X., Zeng, Y.Y., Feng, Y.Z., et al. (2018) Selective β2-Adrenoreceptor Signaling Regulates Osteoclastogenesis via Modulating RANKL Production and Neuropeptides Expression in Osteocytic MLO-Y4 Cells. Journal of Cellular Biochemistry, 120, 7238-7247. [Google Scholar] [CrossRef] [PubMed]
[15] Zang, Y., Tan, Q.C., Ma, X.Y., et al. (2016) Osteogenic Actions of Metoprolol in an Ovariectomized Rat Model of Menopause. Menopause, 23, 1019-1025. [Google Scholar] [CrossRef
[16] Rodrigues, W.F., Madeira, M.F.M., da Silva, T.A., et al. (2012) Low Dose of Propranolol Down-Modulates Bone Resorption by Inhibiting Inflammation and Osteoclast Differentiation. British Journal of Pharmacology, 165, 2140-2151. [Google Scholar] [CrossRef] [PubMed]
[17] Yao, Q.Q., Liang, H.X., Huang, B., et al. (2017) Beta-Adrenergic Signaling Affect Osteoclastogenesis via Osteocytic MLO-Y4 Cells’ RANKL Production. Biochemical and Biophysical Research Communications, 488, 634-640. [Google Scholar] [CrossRef] [PubMed]
[18] Rohleder, N. (2019) Stress and Inflammation—The Need to Address the Gap in the Transition between Acute and Chronic Stress Effects. Psychoneuroendocrinology, 105, 164-171. [Google Scholar] [CrossRef] [PubMed]
[19] Niraula, A., Witcher, K.G., Sheridan, J.F., et al. (2019) Interleukin-6 Induced by Social Stress Promotes a Unique Transcriptional Signature in the Monocytes That Facilitate Anxiety. Biological Psychiatry, 85, 679-689. [Google Scholar] [CrossRef] [PubMed]
[20] He, Z.Y., Sun, Y., Wu, J.M., et al. (2020) Evaluation of Genetic Variants in IL-1B and Its Interaction with the Predisposition of Osteoporosis in the Northwestern Chinese Han Population. Journal of Gene Medicine, e3214. [Google Scholar] [CrossRef] [PubMed]
[21] Li, X., Zhou, Z.-Y., Zhang, Y.-Y., et al. (2016) IL-6 Contributes to the Defective Osteogenesis of Bone Marrow Stromal Cells from the Vertebral Body of the Glucocorticoid-Induced Osteoporotic Mouse. PLoS ONE, 11, e0154677. [Google Scholar] [CrossRef] [PubMed]
[22] Taves, S., Sun, J.J., Livingston, E.W., et al. (2019) Hemophilia A and B Mice, But Not VWFmice, Display Bone Defects in Congenital Development and Remodeling after Injury. Scientific Reports, 9, Article No. 14428. [Google Scholar] [CrossRef] [PubMed]
[23] Eftekhari, H., Hosseini, S.R., Pourreza, B.H., et al. (2018) Association of Interleukin-6 (rs1800796) But Not Transforming Growth Factor Beta 1 (rs1800469) with Serum Calcium Levels in Osteoporotic Patients. Gene, 671, 21-27. [Google Scholar] [CrossRef] [PubMed]
[24] Moffett, S.P., Zmuda, J.M., Oakley, J.I., et al. (2005) Tumor Necrosis Factor-Alpha Polymorphism, Bone Strength Phenotypes, and the Risk of Fracture in Older Women. The Journal of Clinical Endocrinology and Metabolism, 90, 3491-3497. [Google Scholar] [CrossRef] [PubMed]
[25] Islam, A.A., Shahidul, R.L., Yoshikawa, H., et al. (2005) Healing of Fractures in Osteoporotic Rat Mandible Shown by the Expression of Bone Morphogenetic Protein-2 and Tumour Necrosis Factor-Alpha. British Journal of Oral and Maxillofacial Surgery, 43, 383-391. [Google Scholar] [CrossRef] [PubMed]
[26] Liao, L., Su, X.X., Yang, X.H., et al. (2016) TNF-α Inhibits FoxO1 by Upregulating miR-705 to Aggravate Oxidative Damage in Bone Marrow-Derived Mesenchymal Stem Cells during Osteoporosis. Stem Cells, 34, 1054-1067. [Google Scholar] [CrossRef] [PubMed]
[27] Oligschlaeger, Y., Yadati, T., Houben, T., et al. (2019) Inflammatory Bowel Disease: A Stressed “Gut/Feeling”. Cells, 8, 659. [Google Scholar] [CrossRef] [PubMed]
[28] D’Amelio, P. and Sassi, F. (2018) Gut Microbiota, Immune System, and Bone. Calcified Tissue International, 102, 415-425. [Google Scholar] [CrossRef] [PubMed]
[29] Li, L.S., Rao, S.T., Cheng, Y.Z., et al. (2019) Microbial Osteoporosis: The Interplay between the Gut Microbiota and Bones via Host Metabolism and Immunity. Microbiology Open, 8, e00810. [Google Scholar] [CrossRef] [PubMed]
[30] Chen, Y.-C., Greenbaum, J., Shen, H., et al. (2017) Association between Gut Microbiota and Bone Health: Potential Mechanisms and Prospective. The Journal of Clinical Endocrinology and Metabolism, 102, 3635-3646. [Google Scholar] [CrossRef] [PubMed]
[31] Azuma, K., Furuzawa, M., Fujiwara, S., et al. (2015) Effects of Active Mastication on Chronic Stress-Induced Bone Loss in Mice. International Journal of Medical Sciences, 12, 952-957. [Google Scholar] [CrossRef] [PubMed]
[32] Azuma, K., Zhou, Q., Niwa, M., et al. (2017) Association between Mastication, the Hippocampus, and the HPA Axis: A Comprehensive Review. International Journal of Medical Sciences, 18, 1687. [Google Scholar] [CrossRef] [PubMed]
[33] Furuzawa, M., Chen, H.Y., Fujiwara, S., et al. (2014) Chewing Ameliorates Chronic Mild Stress-Induced Bone Loss in Senescence-Accelerated mouse (SAMP8), a Murine Model of Senile Osteoporosis. Experimental Gerontology, 55, 12-18. [Google Scholar] [CrossRef] [PubMed]