微卫星不稳定性与结直肠癌及癌前病变相关性研究进展
Research Progress on the Relationship between Microsatellite Instability and Colorectal Cancer and Precancerous Lesions
摘要: 结直肠癌(Colorectal cancer)是常见的恶性肿瘤之一，其发病率逐年增高。结直肠癌的发病原因与发病机制十分复杂，由错配修复系统(MMR)异常导致的微卫星不稳定性(MSI)与结直肠癌的发生存在着密切联系，这为结直肠癌诊断与治疗提供了许多思路与方法，其中不少MSI相关的结直肠癌的诊断与治疗方法已应用于临床实践中，特别是Lynch综合征的筛选对于患者及其亲属癌症的早期诊断和治疗至关重要。本文将从MSI及其发生机制、MSI与CRC及癌前病变的相关性和MSI检测方法等方面展开，就MSI与CRC及癌前病变相关性的研究进展做一综述。
Abstract: Colorectal cancer (CRC) is one of the common malignant tumors, and its incidence is increasing year by year. The pathogenesis and pathogenesis of colorectal cancer are very complicated. The microsatellite instability (MSI) caused by the abnormality of the mismatch repair system (MMR) is closely related to the occurrence of colorectal cancer, which is the diagnosis and treatment of colorectal cancer. Many ideas and methods are provided. Many of the diagnosis and treatment methods of MSI-related colorectal cancer have been applied in clinical practice. In particular, the screening of Lynch syndrome is very important for the early diagnosis and treatment of cancer of patients and their relatives. This article will review the correlation between MSI and CRC and precancerous lesions.
文章引用：郑雪, 邹佳芮, 李宝华, 张亚楠, 解水杉, 郝俊梅. 微卫星不稳定性与结直肠癌及癌前病变相关性研究进展[J]. 临床医学进展, 2020, 10(11): 2471-2477. https://doi.org/10.12677/ACM.2020.1011373

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