越鞠丸治疗抑郁症较传统西药治疗优越性Meta分析

Meta-Analysis on the Superiority of Yueju Pill over Traditional Western Medicine in Treating Depression

摘要: 目的：系统研究中药越鞠丸治疗抑郁症较西药治疗抑郁症的优越性。方法：在中国知网、万方、维普、PubMed、Europe PMC数据库中检索以越鞠丸治疗抑郁症为基础的文献，并将越鞠丸治疗不同的抑郁症进行分类。先提取各小组纳入文献的数据并进行质量评价，使用Review Manager 5.3软件进行Meta分析，主要结局为治疗有效率，次要结局为HAMD (汉密顿抑郁量表)。再观察各分类小组的异同，以期对纳入的文献进行科学性评价。结果：共纳入13篇文献进行研究，包含1091例抑郁症患者。治疗组以越鞠丸为基础方组总计582例，对照组为传统西药治疗组总计509例。根据Meta分析结果显示：以越鞠丸为基础方治疗原发性抑郁症患者有效率(RR = 1.14, 95% CI [1.00, 1.30], P = 0.06)；治疗脑卒中后抑郁症患者有效率(RR = 1.18, 95% CI [1.00, 1.40], P = 0.05)；治疗原发性抑郁症患者HAMD (SMD = 0.02, 95% CI [−0.27, 0.31], P = 0.89)；治疗脑卒中后抑郁症患者HAMD (SMD = −0.07, 95% CI [−0.30, 0.16], P = 0.53)。结论：以越鞠丸为基础方治疗各种抑郁症(以原发性抑郁和脑卒中后抑郁为例)较传统的西药治疗的效果更明显，且不良反应发生率优于传统西药治疗。

Abstract: Objective: To systematically study the superiority of Yueju Pill in the treatment of depression com-pared with traditional western medicine. Methods: Literature based on the treatment of depression by Yueju Pill was searched in CNKI, WANFANG, VIP, PubMed and Europe PMC databases, and different types of depression were classified. First of all, the data from the included literature of each group were extracted for quality evaluation. Meta-analysis was conducted using Review Manager 5.3 software. The primary outcome was treatment efficiency, while the secondary outcome was HAMD. Then observe the similarities and differences of each classification group in order to make a scientific evaluation of the included literature. Results: A total of 13 articles were included in 1091 patients with depression. A total of 582 patients in the treatment group were treated with Yueju Pill, while 509 patients in the control group were treated with traditional western medicine. Meta-analysis results showed that: using Yueju Pill as the basis for the treatment of primary depression in patients, the efficiency was (R = 1.14, 95% CI [1.00, 1.30], P = 0.06), for the treatment of post-stroke depression (RR = 1.18, 95% CI [1.00, 1.40], P = 0.05), for the treatment of HAMD in pa-tients with primary depression (SMD = 0.02, 95% CI [−0.27, 0.31], P = 0.89), for the treatment of HAMD in patients with post-stroke depression (SMD = −0.07, 95% CI [−0.30, 0.16], P = 0.53). Conclusion: Yueju Pill is more effective in treating various kinds of depression (primary depression and post-stroke depression as examples) than traditional western medicine, and the incidence of adverse reactions is better than traditional western medicine.