磷酸奥司他韦的研究进展
Research Progress of Oseltamivir Phosphate
DOI: 10.12677/HJCET.2020.106058, PDF,   
作者: 魏鹏艳*, 姜玉莹：锦州医科大学药学院，辽宁 锦州；钱 昆：锦州医科大学公共基础学院，辽宁 锦州
关键词: 磷酸奥司他韦；流感；副反应；代谢物；检验方法；Oseltamivir Phosphate； Influenza； Side Effects； Metabolites； Detection Methods
摘要: 磷酸奥司他韦(商品名：达菲)是最有效的口服抗流感神经氨酸酶抑制剂之一，广泛用于A型和B型流行性感冒预防与治疗，小儿手足口病的治疗，磷酸奥司他韦对治疗流感病毒有独特的优势，但此前曾多次报道过服用此药后而导致呕吐、急性呼吸窘迫综合征、心跳加速等副反应，甚至有过自杀的案列。近几年来该药的滥用，有关人员发现的其代谢物对环境产生的一定影响，磷酸奥司他韦(OP)对人体产生的毒副作用及其对环境的影响加速了科研人员对其药物及代谢物进行分析检验，该文综述了近几年国内外对达菲的最新研究进展成果，希望可以为该药的探究进展提供更有效的信息。
Abstract: Oseltamivir phosphate (trade name: Tamiflu) is one of the most effective oral anti-influenza neuraminidase inhibitors, widely used in the prevention and treatment of influenza A and B, and the treatment of hand, foot and mouth disease in children. Oseltamivir phosphate has a unique advantage in the treatment of influenza virus, but it has been reported many times after taking this drug resulting in vomiting, acute respiratory distress syndrome, rapid heartbeat and other side reactions, and even suicide cases. In recent years, the abuse of the drug, a certain impact of its metabolites on the environment found by related personnel, the toxic side effects of oseltamivir phosphate on human body and its impact on the environment accelerated the researchers to analyze and test its drugs and metabolites. This paper reviews the latest research results of Tamiflu in recent years. Hope to provide more effective information on the progress of the drug.
文章引用：魏鹏艳, 姜玉莹, 钱昆. 磷酸奥司他韦的研究进展[J]. 化学工程与技术, 2020, 10(6): 449-455. https://doi.org/10.12677/HJCET.2020.106058

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