没食子酸在抗微生物感染中药理作用的研究进展
Pharmacological Research Progress on Antimicrobial Infection of Gallic Acid
摘要: 没食子酸(Gallic acid, GA)是一种低分子天然多酚类化合物,广泛存在于自然界各种植物,具有多种生物活性。在查阅国内外GA的最新文献基础上,综述了GA在抗细菌、抗真菌、抗病毒、抗寄生虫、抗炎、抗氧化以及在肿瘤、代谢、心血管、神经心理疾病等方面的药理作用研究进展,重点围绕其抗微生物作用,进行分析总结,以期为没食子酸的深入研究或开发应用提供参考。
Abstract: Gallic acid (GA) is a low-molecular natural polyphenolic compound that is widely present in various plants of nature and has a variety of biological activities. On the basis of consulting the latest domestic and foreign literature of GA, the research progress of pharmacological effects of GA in antibacterial, antifungal, antiviral, antiparasitic, anti-inflammatory, anti-oxidant, and tumor, metabolism, cardiovascular, neuropsychological diseases and other aspects is reviewed. Analyze and summarize the antimicrobial effect in order to provide a reference for the in-depth research or development and application of GA.
文章引用:尹娇, 彭旭东, 张杰, 田雪, 张冉冉. 没食子酸在抗微生物感染中药理作用的研究进展[J]. 临床医学进展, 2020, 10(12): 2940-2952. https://doi.org/10.12677/ACM.2020.1012444

参考文献

[1] Wang, Q., de Oliveira, E.F., Alborzi, S., et al. (2017) On Mechanism Behind UV-A Light Enhanced Antibacterial Activity of Gallic Acid and Propyl Gallate against Escherichia coli O157:H7. Scientific Reports, 7, 8325. [Google Scholar] [CrossRef] [PubMed]
[2] Kahkeshani, N., Farzaei, F., Fotouhi, M., et al. (2019) Pharmacological Effects of Gallic Acid in Health and Diseases: A Mechanistic Review. Iranian Journal of Basic Medical Sciences, 22, 225-237.
[3] Fernandes, F.H.A. and Salgado, H.R.N. (2016) Gallic Acid: Review of the Methods of Determination and Quantification. Critical Reviews in Analytical Chemistry, 46, 257-265. [Google Scholar] [CrossRef] [PubMed]
[4] Chanwitheesuk, A., Teerawutgulrag, A., Kilburn, J.D., et al. (2007) Antimicrobial Gallic acid from Caesalpinia mimosoides Lamk. Food Chemistry, 100, 1044-1048. [Google Scholar] [CrossRef
[5] Borges, A., Saavedra, M.J. and Simões, M. (2012) The Activity of Ferulic and Gallic Acids in Biofilm Prevention and Control of Pathogenic Bacteria. Biofouling, 28, 755-767. [Google Scholar] [CrossRef] [PubMed]
[6] Fu, L., Lu, W. and Zhou, X. (2016) Phenolic Compounds and in Vitro Antibacterial and Antioxidant Activities of Three Tropic Fruits: Persimmon, Guava, and Sweetsop. BioMed Research International, 2016, Article ID: 4287461. [Google Scholar] [CrossRef] [PubMed]
[7] Taguri, T., Tanaka, T. and Kouno, I. (2006) Antibacterial Spectrum of Plant Polyphenols and Extracts Depending upon Hydroxyphenyl Structure. Biological and Pharmaceutical Bulletin, 29, 2226-2235. [Google Scholar] [CrossRef] [PubMed]
[8] Saavedra, M.J., Borges, A., Dias, C., et al. (2010) Antimicrobial Activity of Phenolics and Glucosinolate Hydrolysis Products and their Synergy with Streptomycin against Pathogenic Bacteria. Medicinal Chemistry, 6, 174-183. [Google Scholar] [CrossRef] [PubMed]
[9] Rattanata, N., Klaynongsruang, S., Daduang, S., et al. (2016) Inhibitory Effects of Gallic Acid Isolated from Caesalpinia mimosoides Lamk on Cholangiocarcinoma Cell Lines and Foodborne Pathogenic Bacteria. Asian Pacific Journal of Cancer Prevention, 17, 1341-1345. [Google Scholar] [CrossRef
[10] Kang, M.-S., Oh, J.-S., Kang, I.-C., et al. (2008) Inhibitory Effect of Methyl Gallate and Gallic Acid on Oral Bacteria. The Journal of Microbiology, 46, 744-750. [Google Scholar] [CrossRef] [PubMed]
[11] Wang, Y. and Lam, A.T.W. (2020) Epigallocatechin Gallate and Gallic Acid Affect Colonization of Abiotic Surfaces by Oral Bacteria. Archives of Oral Biology, 120, Article ID: 104922. [Google Scholar] [CrossRef] [PubMed]
[12] Sendamangalam, V., Choi, O.K., Kim, D., et al. (2011) The Anti-Biofouling Effect of Polyphenols against Streptococcus mutans. Biofouling, 27, 13-19. [Google Scholar] [CrossRef] [PubMed]
[13] Campos, F.M., Couto, J.A., Figueiredo, A.R., et al. (2009) Cell Membrane Damage Induced by Phenolic Acids on Wine Lactic Acid Bacteria. International Journal of Food Microbiology, 135, 144-151. [Google Scholar] [CrossRef] [PubMed]
[14] Campos, F.M., Couto, J.A. and Hogg, T.A. (2003) Influence of Phenolic Acids on Growth and Inactivation of Oenococcus oeni and Lactobacillus hilgardii. Journal of Applied Microbiology, 94, 167-174. [Google Scholar] [CrossRef] [PubMed]
[15] Han, S.S., Hur, S.J. and Lee, S.K. (2015) A Comparison of Antioxidative and Anti-Inflammatory Activities of Sword Beans and Soybeans Fermented with Bacillus subtilis. Food & Function, 6, 2736-2748. [Google Scholar] [CrossRef
[16] Shao, D., Li, J., Li, J., et al. (2015) Inhibition of Gallic Acid on the Growth and Biofilm Formation of Escherichia coli and Streptococcus mutans. Journal of Food Science, 80, M1299-M305. [Google Scholar] [CrossRef] [PubMed]
[17] Puupponen-Pimiä, R., Nohynek, L., Hartmann-Schmidlin, S., et al. (2005) Berry Phenolics Selectively Inhibit the Growth of Intestinal Pathogens. Journal of Applied Microbiology, 98, 991-1000. [Google Scholar] [CrossRef] [PubMed]
[18] Rauha, J.-P., Remes, S., Heinonen, M., et al. (2000) Antimicrobial Effects of Finnish Plant Extracts Containing Flavonoids and Other Phenolic Compounds. International Journal of Food Microbiology, 56, 3-12. [Google Scholar] [CrossRef
[19] Rui, Y., Ying, G., Jinwei, Z., et al. (2018) Phytochemicals from Camellia nitidissima Chi Flowers Reduce the Pyocyanin Production and Motility of Pseudomonas aeruginosa PAO1. Frontiers in Microbiology, 8, 2640.
[20] Borges, A., Ferreira, C., Saavedra, M.J., et al. (2013) Antibacterial Activity and Mode of Action of Ferulic and Gallic Acids against Pathogenic Bacteria. Microbial Drug Resistance (Larchmont, NY), 19, 256-265. [Google Scholar] [CrossRef] [PubMed]
[21] Jing, L., Zhenning, W., Mengrou, R., et al. (2016) Antibacterial Effect of Gallic Acid against Aeromonas hydrophila and Aeromonas sobria through Damaging Membrane Integrity. Current Pharmaceutical Biotechnology, 17, 1153-1158. [Google Scholar] [CrossRef] [PubMed]
[22] Sowndarya, J., Rubini, D., Sinsinwar, S., et al. (2020) Gallic Acid an Agricultural Byproduct Modulates the Biofilm Matrix Exopolysaccharides of the Phytopathogen Ralstonia solanacearum. Current Microbiology, 77, 3339-3354. [Google Scholar] [CrossRef] [PubMed]
[23] Díaz-Gómez, R., López-Solís, R., Obreque-Slier, E., et al. (2013) Comparative Antibacterial Effect of Gallic Acid and Catechin against Helicobacter Pylori. LWT-Food Science and Technology, 54, 331-335. [Google Scholar] [CrossRef
[24] Maddox, C.E., Laur, L.M. and Tian, L. (2010) Antibacterial Activity of Phenolic Compounds against the Phytopathogen Xylella Fastidiosa. Current Microbiology, 60, 53-58. [Google Scholar] [CrossRef] [PubMed]
[25] Hossan, M.S., Jindal, H., Maisha, S., et al. (2018) Antibacterial Effects of 18 Medicinal Plants Used by the Khyang Tribe in Bangladesh. Pharmaceutical Biology, 56, 201-208. [Google Scholar] [CrossRef] [PubMed]
[26] Sarjit, A., Wang, Y. and Dykes, G.A. (2015) Antimicrobial Activity of Gallic Acid against Thermophilic Campylobacter is Strain Specific and Associated with a Loss of Calcium Ions. Food Microbiology, 46, 227-233. [Google Scholar] [CrossRef] [PubMed]
[27] Lim, H.J., Jeon, Y.D., Kang, S.H., et al. (2018) Inhibitory Effects of Euphorbia supina on Propionibacterium Acnes-Induced Skin Inflammation in Vitro and in Vivo. BMC Complementary Medicine and Therapies, 18, 263. [Google Scholar] [CrossRef] [PubMed]
[28] Pedroso, R.D.S., Balbino, B.L., Andrade, G., et al. (2019) In Vitro and in Vivo Anti-Candida spp. Activity of Plant-Derived Products. Plants (Basel, Switzerland), 8, 494. [Google Scholar] [CrossRef] [PubMed]
[29] Teodoro, G.R., Gontijo, A.V.L., Salvador, M.J., et al. (2018) Effects of Acetone Fraction from Buchenavia tomentosa Aqueous Extract and Gallic Acid on Candida albicans Biofilms and Virulence Factors. Frontiers in Microbiology, 9, 647. [Google Scholar] [CrossRef] [PubMed]
[30] Li, Z.-J., Liu, M., Dawuti, G., et al. (2017) Antifungal Activity of Gallic Acid in Vitro and in Vivo. Phytotherapy Research, 31, 1039-1045. [Google Scholar] [CrossRef] [PubMed]
[31] Sony, P., Kalyani, M., Jeyakumari, D., et al. (2018) In Vitro Antifungal Activity of Cassia Fistula Extracts against Fluconazole Resistant Strains of Candida Species from HIV Patients. Journal De Mycologie Medicale, 28, 193-200. [Google Scholar] [CrossRef] [PubMed]
[32] de Paula, E., Silva, A.C.A., Costa-Orlandi, C.B., Gullo, F.P., et al. (2014) Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi. Evidence-Based Complementary and Alternative Medicine, 2014, Article ID: 506273. [Google Scholar] [CrossRef] [PubMed]
[33] Nguyen, D.M., Seo, D.J., Lee, H.B., et al. (2013) Antifungal Activity of Gallic Acid Purified from Terminalia nigrovenulosa Bark against Fusarium solani. Microbial Pathoge, 56, 8-15. [Google Scholar] [CrossRef] [PubMed]
[34] De León-Zapata, M.A., Pastrana-Castro, L., Rua-Rodríguez, M.L., et al. (2016) Experimental Protocol for the Recovery and Evaluation of Bioactive Compounds of Tarbush against Postharvest Fruit Fungi. Food Chemistry, 198, 62-67. [Google Scholar] [CrossRef] [PubMed]
[35] Ito, S., Nakagawa, Y., Yazawa, S., et al. (2014) Antifungal Activity of Alkyl Gallates against Plant Pathogenic Fungi. Bioorganic & Medicinal Chemistry Letters, 24, 1812-1814. [Google Scholar] [CrossRef] [PubMed]
[36] Lam, P.L., Gambari, R., Kok, S.H., et al. (2015) Non-Toxic Agarose/Gelatin-Based Microencapsulation System Containing Gallic Acid for Antifungal Application. International Journal of Molecular Medicine, 35, 503-510. [Google Scholar] [CrossRef] [PubMed]
[37] Céspedes, C.L., Salazar, J.R., Ariza-Castolo, A., et al. (2014) Biopesticides from Plants: Calceolaria Integrifolia s.l. Environmental Research, 132, 391-406. [Google Scholar] [CrossRef] [PubMed]
[38] Rangkadilok, N., Tongchusak, S., Boonhok, R., et al. (2012) In Vitro Antifungal Activities of Longan (Dimocarpus longan Lour.) Seed Extract. Fitoterapia, 83, 545-553. [Google Scholar] [CrossRef] [PubMed]
[39] Gehrke, I.T.S., Neto, A.T., Pedroso, M., et al. (2013) Antimicrobial Activity of Schinus lentiscifolius (Anacardiaceae). Journal of Ethnopharmacology, 148, 486-491. [Google Scholar] [CrossRef] [PubMed]
[40] Govea-Salas, M., Rivas-Estilla, A.M., Rodríguez-Herrera, R., et al. (2016) Gallic Acid Decreases Hepatitis C Virus Expression through Its Antioxidant Capacity. Experimental and Therapeutic Medicine, 11, 619-624. [Google Scholar] [CrossRef] [PubMed]
[41] Hsu, W.-C., Chang, S.-P., Lin, L.-C., et al. (2015) Limonium Sinense and Gallic Acid Suppress Hepatitis C Virus Infection by Blocking Early Viral Entry. Antiviral Research, 118, 139-147. [Google Scholar] [CrossRef] [PubMed]
[42] Aoki, C., Hartati, S., Santi, M., et al. (2014) Isolation and Identification of Substances with Anti-Hepatitis C Virus Activities from Kalanchoe pinnata. International Journal of Pharmaceutics, 6, 211-215.
[43] Liu, S., Chen, R. and Hagedorn, C.H. (2015) Tannic Acid Inhibits Hepatitis C Virus Entry into Huh7.5 Cells. PLoS One, 10, e0131358. [Google Scholar] [CrossRef] [PubMed]
[44] Alam, P., Parvez, M.K., Arbab, A.H., et al. (2017) Quantitative Analysis of Rutin, Quercetin, Naringenin, and Gallic Acid by Validated RP- and NP-HPTLC Methods for Quality Control of Anti-HBV Active Extract of Guiera senegalensis. Pharmaceutical Biology, 55, 1317-1323. [Google Scholar] [CrossRef] [PubMed]
[45] You, H.-L., Huang, C.-C., Chen, C.-J., et al. (2018) Anti-Pandemic Influenza A (H1N1) Virus Potential of Catechin and Gallic Acid. Journal of the Chinese Medical Association, 81, 458-468. [Google Scholar] [CrossRef] [PubMed]
[46] Lee, J.-H., Oh, M., Seok, J.H., et al. (2016) Antiviral Effects of Black Raspberry (Rubus coreanus) Seed and Its Gallic Acid against Influenza Virus Infection. Viruses, 8, 157. [Google Scholar] [CrossRef] [PubMed]
[47] Theisen, L.L., Erdelmeier, C.A.J., Spoden, G.A., et al. (2014) Tannins from Hamamelis virginiana Bark Extract: Characterization and Improvement of the Antiviral Efficacy against Influenza A Virus and Human Papillomavirus. PLoS ONE, 9, e88062. [Google Scholar] [CrossRef] [PubMed]
[48] Kratz, J.M., Andrighetti-Fröhner, C.R., Kolling, D.J., et al. (2008) Anti-HSV-1 and Anti-HIV-1 Activity of Gallic Acid and Pentyl Gallate. Memórias do Instituto Oswaldo Cruz, 103, 437-442. [Google Scholar] [CrossRef
[49] Uozaki, M., Yamasaki, H., Katsuyama, Y., et al. (2007) Antiviral Effect of Octyl Gallate against DNA and RNA Viruses. Antiviral Research, 73, 85-91. [Google Scholar] [CrossRef] [PubMed]
[50] Vilhelmova-Ilieva, N., Jacquet, R., Deffieux, D., et al. (2019) Anti-Herpes Simplex Virus Type 1 Activity of Specially Selected Groups of Tannins. Drug Research, 69, 373-374. [Google Scholar] [CrossRef] [PubMed]
[51] Mirani, A., Kundaikar H., Velhal, S., et al. (2019) Evaluation of Phytopolyphenols for Their gp120-CD4 Binding Inhibitory Properties by in Silico Molecular Modelling & in Vitro Cell Line Studies. Current HIV Research, 17, 102-113. [Google Scholar] [CrossRef
[52] Nutan, Modi, M., Goel, T., et al. (2013) Ellagic Acid & Gallic Acid from Lagerstroemia speciosa L. Inhibit HIV-1 Infection through Inhibition of HIV-1 Protease & Reverse Transcriptase Activity. Indian Journal of Medical Research, 137, 540-548.
[53] Rivero-Buceta, E., Carrero, P., Doyagüez, E.G., et al. (2015) Linear and Branched Alkyl-Esters and Amides of Gallic Acid and Other (mono-, di- and tri-) Hydroxy Benzoyl Derivatives as Promising Anti-HCV Inhibitors. European Journal of Medicinal Chemistry, 92, 656-671. [Google Scholar] [CrossRef] [PubMed]
[54] Maurya, V.K., Kumar, S., Prasad, A.K., et al. (2020) Structure-Based Drug Designing for Potential Antiviral Activity of Selected Natural Products from Ayurveda against SARS-CoV-2 Spike Glycoprotein and Its Cellular Receptor. VirusDisease, 31, 179-193. [Google Scholar] [CrossRef] [PubMed]
[55] Weng, J.-R., Lin, C.-S., Lai, H.-C., et al. (2019) Antiviral Activity of Sambucus FormosanaNakai Ethanol Extract and Related Phenolic Acid Constituents against Human Coronavirus NL63. Virus Research, 273, Article ID: 197767. [Google Scholar] [CrossRef] [PubMed]
[56] Cui, Q., Du, R., Anantpadma, M., et al. (2018) Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor. Viruses, 10, 152. [Google Scholar] [CrossRef] [PubMed]
[57] Mi, O., Bae, S.Y., Lee, J.H., et al. (2012) Antiviral Effects of Black Raspberry (Rubus coreanus) Juice on Foodborne Viral Surrogates. Foodborne Pathogens and Disease, 9, 915-921. [Google Scholar] [CrossRef] [PubMed]
[58] Zhang, X.-F., Dai, Y.-C., Zhong, W., et al. (2012) Tannic Acid Inhibited Norovirus Binding to HBGA Receptors, a Study of 50 Chinese Medicinal Herbs. Bioorganic & Medicinal Chemistry, 20, 1616-1623. [Google Scholar] [CrossRef] [PubMed]
[59] Trujillo-Correa, A.I., Quintero-Gil, D.C., Diaz-Castillo, F., et al. (2019) In Vitro and in Silico Anti-Dengue Activity of Compounds Obtained from Psidium guajava through Bioprospecting. BMC Complementary Medicine and Therapies, 19, 298. [Google Scholar] [CrossRef] [PubMed]
[60] Choi, H.J., Song, J.H., Bhatt, L.R., et al. (2010) Anti-Human Rhinovirus Activity of Gallic Acid Possessing Antioxidant Capacity. Phytotherapy Research, 24, 1292-1296. [Google Scholar] [CrossRef] [PubMed]
[61] Choi, H.J., Song, J.H., Park, K.S., et al. (2010) In Vitro Anti-Enterovirus 71 Activity of Gallic Acid from Woodfordia fruticosa Flowers. Letters in Applied Microbiology, 50, 438-440. [Google Scholar] [CrossRef
[62] Cortes, L.A., Castro, L., Pesce, B., et al. (2015) Novel Gallate Triphenylphosphonium Derivatives with Potent Antichagasic Activity. PLoS One, 10, e0136852. [Google Scholar] [CrossRef] [PubMed]
[63] Amisigo, C.M., Antwi, C.A., Adjimani, J.P., et al. (2019) In Vitro Anti-Trypanosomal Effects of Selected Phenolic Acids on Trypanosoma brucei. PLoS ONE, 14, e0216078. [Google Scholar] [CrossRef] [PubMed]
[64] Andréo, R., Regasini, L.O., Petrônio, M.S., et al. (2015) Toxicity and Loss of Mitochondrial Membrane Potential Induced by Alkyl Gallates in Trypanosoma cruzi. International Scholarly Research Notices, 2015, Article ID: 924670. [Google Scholar] [CrossRef] [PubMed]
[65] Mehwish, S., Khan, H., Rehman, A.U., et al. (2019) Natural Compounds from Plants Controlling Leishmanial Growth via DNA Damage and Inhibiting Trypanothione Reductase and Trypanothione Synthetase: An in Vitro and in Silico Approach. 3 Biotech, 9, Article No. 303. [Google Scholar] [CrossRef] [PubMed]
[66] Alves, M.M.D.M, Brito, L.M., Souza, A.C., et al. (2017) Gallic and Ellagic Acids: Two Natural Immunomodulator Compounds Solve Infection of Macrophages by Leishmania Major. Naunyn-Schmiedeberg’s Archives of Pharmacology, 390, 893-903. [Google Scholar] [CrossRef] [PubMed]
[67] Tasdemir, D., Kaiser, M., et al. (2006) Antitrypanosomal and Antileishmanial Activities of Flavonoids and Their Analogues: In Vitro, in Vivo, Structure-Activity Relationship, and Quantitative Structure-Activity Relationship Studies. [Google Scholar] [CrossRef
[68] Ndjonka, D., Djafsia, B. and Liebau, E. (2018) Review on Medicinal Plants and Natural Compounds as Anti-Onchocerca Agents. Parasitology Research, 117, 2697-2713. [Google Scholar] [CrossRef] [PubMed]
[69] Ndjonka, D., Abladam, E.D., Djafsia, B., et al. (2014) Anthelmintic Activity of Phenolic Acids from the Axlewood Tree Anogeissus leiocarpus on the Filarial Nematode Onchocerca ochengi and Drug-Resistant Strains of the Free-Living Nematode Caenorhabditis elegans. Journal of Helminthology, 88, 481-488. [Google Scholar] [CrossRef
[70] Engström, M.T., Karonen, M., Ahern, J.R., et al. (2016) Chemical Structures of Plant Hydrolyzable Tannins Reveal Their in Vitro Activity against Egg Hatching and Motility of Haemonchus contortus Nematodes. Journal of Agricultural and Food Chemistry, 64, 840-851. [Google Scholar] [CrossRef] [PubMed]
[71] Cock, I.E. and Rayan, P. (2020) Ascorbic Acid Potentiates the Giardia duodenalis Growth Inhibitory Activity of Pure Terminalia ferdinandiana Exell Compounds. Parasitology Research, 119, 1125-1137. [Google Scholar] [CrossRef] [PubMed]
[72] Bolson, N.C., Urach, M.D., de, B.T.F., et al. (2017) In Vitro Effects of Blepharocalyx salicifolius (H.B.K.) O. Berg on the Viability of Echinococcus ortleppi Protoscoleces. Revista do Instituto de Medicina Tropical de São Paulo, 59, e42. [Google Scholar] [CrossRef] [PubMed]
[73] Nguyen-Ngo, C., Salomon, C., Lai, A., et al. (2020) Anti-Inflammatory Effects of Gallic Acid in Human Gestational Tissues in Vitro. Reproduction (Cambridge, England), 160, 561-578. [Google Scholar] [CrossRef
[74] Shree, A., Islam, J., Vafa, A., et al. (2020) Gallic Acid Prevents 1, 2-Dimethylhydrazine Induced Colon Inflammation, Toxicity, Mucin Depletion, and Goblet Cell Disintegration. Environmental Toxicology, 35, 652-664. [Google Scholar] [CrossRef] [PubMed]
[75] Zhu, L., Gu, P. and Shen, H. (2019) Gallic Acid Improved Inflammation via NF-κB Pathway in TNBS-Induced Ulcerative Colitis. International Immunopharmacology, 67, 129-137. [Google Scholar] [CrossRef] [PubMed]
[76] Wang, X., Zhao, H., Ma, C., et al. (2018) Gallic Acid Attenuates Allergic Airway Inflammation via Suppressed Interleukin-33 and Group 2 Innate Lymphoid Cells in Ovalbumin-Induced Asthma in Mice. International Forum of Allergy & Rhinology, 8, 1284-1290. [Google Scholar] [CrossRef] [PubMed]
[77] Fan, Y., Piao, C.H., Hyeon, E., et al. (2019) Gallic Acid Alleviates Nasal Inflammation via Activation of Th1 and Inhibition of Th2 and Th17 in a Mouse Model of Allergic Rhinitis. International Immunopharmacology, 70, 512-519. [Google Scholar] [CrossRef] [PubMed]
[78] Saygin, M., Ozturk, O., Ozmen, O., et al. (2016) The Impact of Methotrexate on Lung Inflammatory and Apoptotic Pathway Biomarkers—The Role of Gallic Acid. Biomed Pharmacother, 84, 1689-1696. [Google Scholar] [CrossRef] [PubMed]
[79] Karatas, O. and Gevrek, F. (2020) 3,4,5-Trihydroxybenzoic Acid Attenuates Ligature-Induced Periodontal Disease in Wistar Rats. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 19. [Google Scholar] [CrossRef] [PubMed]
[80] Tsang, M.S., Jiao, D., Chan, B.C., et al. (2016) Anti-Inflammatory Activities of Pentaherbs Formula, Berberine, Gallic Acid and Chlorogenic Acid in Atopic Dermatitis-Like Skin Inflammation. Molecules (Basel, Switzerland), 21, 519. [Google Scholar] [CrossRef] [PubMed]
[81] Chong-Hyeon, Y., et al. (2013) Gallic Acid, a Natural Polyphenolic Acid, Induces Apoptosis and Inhibits Proinflammatory Gene Expressions in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Joint Bone Spine, 80, 274-279. [Google Scholar] [CrossRef] [PubMed]
[82] Esmaeilzadeh, M., Heidarian, E., Shaghaghi, M., et al. (2020) Gallic Acid Mitigates Diclofenac-Induced Liver Toxicity by Modulating Oxidative Stress and Suppressing IL-1β Gene Expression in Male Rats. Pharmaceutical Biology, 58, 590-596. [Google Scholar] [CrossRef] [PubMed]
[83] Hosseinzadeh, A., Houshmand, G., Goudarzi, M., et al. (2019) Ameliorative Effect of Gallic Acid on Sodium Arsenite-Induced Spleno-, Cardio- and Hemato-Toxicity in Rats. Life Sciences, 217, 91-100. [Google Scholar] [CrossRef] [PubMed]
[84] Dutta, M. and Paul, G. (2019) Gallic Acid Protects Rat Liver Mitochondria ex Vivo from Bisphenol A Induced Oxidative Stress Mediated Damages. Toxicology Reports, 6, 578-589. [Google Scholar] [CrossRef] [PubMed]
[85] Schimites, P.I., Segat, H.J., Teixeira, L.G., et al. (2020) Gallic Acid Prevents Ketamine-Induced Oxidative Damages in Brain Regions and Liver of Rats. Neuroscience Letters, 714, Article ID: 134560. [Google Scholar] [CrossRef] [PubMed]
[86] Nouri, A., Heibati, F. and Heidarian, E. (2020) Gallic Acid Exerts Anti-Inflammatory, Anti-Oxidative Stress, and Nephroprotective Effects against Paraquat-Induced Renal Injury in Male Rats. Naunyn-Schmiedeberg’s Archives of Pharmacology, 393. [Google Scholar] [CrossRef] [PubMed]
[87] Radan, M., Dianat, M., Badavi, M., et al. (2019) In Vivo and in Vitro Evidence for the Involvement of Nrf2-Antioxidant Response Element Signaling Pathway in the Inflammation and Oxidative Stress Induced by Particulate Matter (PM10): The Effective Role of Gallic Acid. Free Radical Research, 53, 210-225. [Google Scholar] [CrossRef] [PubMed]
[88] Owumi, S.E., Adedara, I.A., Akomolafe, A.P., et al. (2020) Gallic Acid Enhances Reproductive Function by Modulating Oxido-Inflammatory and Apoptosis Mediators in Rats Exposed to Aflatoxin-B1. Experimental Biology and Medicine (Maywood), 245, 1016-1028. [Google Scholar] [CrossRef] [PubMed]
[89] Mehraban, Z., Novin, M.G., Golmohammadi, M.G., et al. (2019) Protective Effect of Gallic Acid on Apoptosis of Sperm and in Vitro Fertilization in Adult Male Mice Treated with Cyclophosphamide. Journal of Cellular Biochemistry, 120, 17250-17257. [Google Scholar] [CrossRef] [PubMed]
[90] Liao, C.-C., Chen, S.-C., Huang, H.-P., et al. (2018) Gallic Acid Inhibits Bladder Cancer Cell Proliferation and Migration via Regulating Fatty Acid Synthase (FAS). Journal of Food and Drug Analysis, 26, 620-627. [Google Scholar] [CrossRef] [PubMed]
[91] Zeng, M., Su, Y., Li, K., et al. (2020) Gallic Acid Inhibits Bladder Cancer T24 Cell Progression through Mitochondrial Dysfunction and PI3K/Akt/NF-κB Signaling Suppression. Frontiers in Pharmacology, 11, 1222. [Google Scholar] [CrossRef] [PubMed]
[92] Park, W. (2016) Gallic Acid Induces HeLa Cell Death via Increasing GSH Depletion rather than ROS Levels. Oncology Reports, 37, 1277-1283. [Google Scholar] [CrossRef] [PubMed]
[93] Rezaei-Seresht, H., Cheshomi, H., Falanji, F., et al. (2019) Cytotoxic Activity of Caffeic Acid and Gallic Acid against MCF-7 Human Breast Cancer Cells: An in Silico and in Vitro Study. Avicenna Journal of Phytomedicine, 9, 574-86.
[94] Gu, R., Zhang, M., Meng, H., et al. (2018) Gallic Acid Targets Acute Myeloid Leukemia via Akt/mTOR-Dependent Mitochondrial Respiration Inhibition. Biomed Pharmacother, 105, 491-497. [Google Scholar] [CrossRef] [PubMed]
[95] Lin, M.-L. and Chen, S.-S. (2017) Activation of Casein Kinase II by Gallic Acid Induces BIK-BAX/BAK-Mediated ER Ca++-ROS-Dependent Apoptosis of Human Oral Cancer Cells. Frontiers in Physiology, 8, 761. http://europepmc.org/abstract/MED/29033852 https://europepmc.org/articles/PMC5627504 https://europepmc.org/articles/PMC5627504?pdf=render [Google Scholar] [CrossRef] [PubMed]
[96] Pang, J.-H.S., Yen, J.-H., Wu, H.-T., et al. (2017) Gallic Acid Inhibited Matrix Invasion and AP-1/ETS-1-Mediated MMP-1 Transcription in Human Nasopharyngeal Carcinoma Cells. International Journal of Molecular Sciences, 18, 1354. http://europepmc.org/abstract/MED/28672814 https://europepmc.org/articles/PMC5535847 https://europepmc.org/articles/PMC5535847?pdf=render [Google Scholar] [CrossRef] [PubMed]
[97] Variya, B.C., Bakrania, A.K. and Patel, S.S. (2019) Antidiabetic Potential of Gallic Acid from Emblica officinalis: Improved Glucose Transporters and Insulin Sensitivity through PPAR-γ and Akt Signaling. Phytomedicine, 2019, Article ID: 152906. [Google Scholar] [CrossRef] [PubMed]
[98] Punithavathi, V.R., Prince, P.S.M., Kumar, R., et al. (2011) Antihyperglycaemic, Antilipid Peroxidative and Antioxidant Effects of Gallic Acid on Streptozotocin Induced Diabetic Wistar Rats. European Journal of Pharmacology, 650, 465-471. [Google Scholar] [CrossRef] [PubMed]
[99] Huang, D.-W., Chang, W.-C., Wu, J.S.-B., et al. (2016) Gallic Acid Ameliorates Hyperglycemia and Improves Hepatic Carbohydrate Metabolism in Rats Fed a High-Fructose Diet. Nutrition Research, 36, 150-160. [Google Scholar] [CrossRef] [PubMed]
[100] de Oliveira, L.S., Thomé, G.R., Lopes, T.F., et al. (2016) Effects of Gallic Acid on Delta—Aminolevulinic Dehydratase Activity and in the Biochemical, Histological and Oxidative Stress Parameters in the Liver and Kidney of Diabetic Rats. Biomed Pharmacother, 84, 1291-1299. [Google Scholar] [CrossRef] [PubMed]
[101] Garud, M.S. and Kulkarni, Y.A. (2018) Gallic Acid Attenuates Type I Diabetic Nephropathy in Rats. Chemico-Biological Interactions, 282, 69-76. [Google Scholar] [CrossRef] [PubMed]
[102] Abdel-Moneim, A., Yousef, A.I., Abd El-Twab, S.M., et al. (2017) Gallic Acid and p-Coumaric Acid Attenuate Type 2 Diabetes-Induced Neurodegeneration in Rats. Metabolic Brain Disease, 32, 1279-1286. [Google Scholar] [CrossRef] [PubMed]
[103] Huang, D.W., Chang, W.-C., Yang, H.-J., et al. (2018) Gallic Acid Alleviates Hypertriglyceridemia and Fat Accumulation via Modulating Glycolysis and Lipolysis Pathways in Perirenal Adipose Tissues of Rats Fed a High-Fructose Diet. International Journal of Molecular Sciences, 19, 254. [Google Scholar] [CrossRef] [PubMed]
[104] Ferk, F., Kundi, M., Brath, H., et al. (2018) Gallic Acid Improves Health-Associated Biochemical Parameters and Prevents Oxidative Damage of DNA in Type 2 Diabetes Patients: Results of a Placebo-Controlled Pilot Study. Molecular Nutrition & Food Research, 62, Article ID: 1700482. [Google Scholar] [CrossRef] [PubMed]
[105] Yan, X., Zhang, Q.Y., Zhang, Y.L., et al. (2020) Gallic Acid Attenuates Angiotensin II-Induced Hypertension and Vascular Dysfunction by Inhibiting the Degradation of Endothelial Nitric Oxide Synthase. Frontiers in Pharmacology, 11, 1121. [Google Scholar] [CrossRef] [PubMed]
[106] Du, Y.-Y., Zou, L., Wang, X.-X., et al. (2020) Inhibitory Effect of Gallic Acid on Voltage-Gated Na+ Channels in Rat Cardiomyocytes. Clinical and Experimental Pharmacology & Physiology, 47, 771-779.
[107] Jin, L., Piao, Z.H., Sun, S., et al. (2017) Gallic Acid Reduces Blood Pressure and Attenuates Oxidative Stress and Cardiac Hypertrophy in Spontaneously Hypertensive Rats. Scientific Reports, 7, Article ID: 15607. [Google Scholar] [CrossRef] [PubMed]
[108] Mori, T., Koyama, N., Yokoo, T., et al. (2020) Gallic Acid is a Dual α/β-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice. The Journal of Biological Chemistry, 295, 16251-16266. [Google Scholar] [CrossRef
[109] Park, C.S., Lee, J.Y., Choi, H.Y., et al. (2020) Gallic Acid Attenuates Blood-Spinal Cord Barrier Disruption by Inhibiting Jmjd3 Expression and Activation after Spinal Cord Injury. Neurobiology of Disease, 145, Article ID: 105077. [Google Scholar] [CrossRef] [PubMed]
[110] Wang, X.X., Liu, K., Ruan, M.Y., et al. (2018) Gallic Acid Inhibits Fibroblast Growth and Migration in Keloids through the AKT/ERK Signaling Pathway. Acta Biochimica et Biophysica Sinica, 50, 1114-1120. [Google Scholar] [CrossRef] [PubMed]
[111] Seyed, N., Solomon, H., Arianna, D.L., et al. (2016) Post-Stroke Depression Modulation and in Vivo Antioxidant Activity of Gallic Acid and Its Synthetic Derivatives in a Murine Model System. Nutrients, 8, 248. [Google Scholar] [CrossRef] [PubMed]
[112] Guo, L., Cao, J.-H., Wei, T.-T., et al. (2019) Gallic Acid Attenuates Thymic Involution in the d-Galactose Induced Accelerated Aging Mice. Immunobiology, 2019, Article ID: 151870. [Google Scholar] [CrossRef] [PubMed]