微RNA在脑缺血/再灌注损伤中作用的研究进展
Research Progress on Effects of MicroRNA in Cerebral Ischemia/Reperfusion Injury
DOI: 10.12677/ACM.2020.1012448, PDF,    科研立项经费支持
作者: 孙贵亮：青岛大学，山东 青岛；王 晓, 张高峰, 陈怀龙, 孙晓鹏, 秦伟伟, 时 飞, 王明山*：青岛大学附属青岛市市立医院麻醉科，山东 青岛
关键词: 脑缺血/再灌注损伤；发病机制；微小RNA；Cerebral Ischemia/Reperfusion Injury； Pathogenesis； MicroRNA
摘要: 脑缺血/再灌注损伤(cerebral ischemia/reperfusion injury, CIRI)是脑缺血患者恢复血流灌注时常见的病理生理现象，其发病机制涉及多个环节，主要与能量代谢障碍、Ca2+超载、氧化应激、炎症反应等机制有关。微小核糖核酸(miRNA)是一种近年来发现的存在于真核生物中的非编码调控RNA，其作用机制主要是在转录后水平上调控基因的表达。近期研究发现，相关miRNAs参与CIRI的发生发展过程。本文将概述CIRI发病机制，综述相关miRNAs调控CIRI进程的作用，为CIRI的防治提供新的靶点和思路。
Abstract: Cerebral ischemia/reperfusion injury (CIRI) is a common pathophysiological phenomenon in the recovery of blood flow in patients with cerebral ischemia. The pathogenesis involves multiple pathways, mainly related to energy metabolism disorder, Ca2+ overload, oxidative stress, inflammatory reaction and so on. MicroRNA is a small non-coding regulation RNA in eukaryotes found in recent years. Its mechanism is mainly regulation of gene expression after transcription. Recent studies have found that related miRNAs are involved in the development of CIRI. This paper mainly reviews the pathogenesis of CIRI, describes the role of related miRNAs in the regulation of CIRI, and provides new targets and ideas for the prevention and treatment of CIRI.
文章引用：孙贵亮, 王晓, 张高峰, 陈怀龙, 孙晓鹏, 秦伟伟, 时飞, 王明山. 微RNA在脑缺血/再灌注损伤中作用的研究进展[J]. 临床医学进展, 2020, 10(12): 2978-2985. https://doi.org/10.12677/ACM.2020.1012448

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