PLR及NLR对子痫前期预测价值的研究进展

Research Progress on the Predictive Value of PLR and NLR in Preeclampsia

摘要: 子痫前期(pre-eclampsia, PE)是妊娠特有的全身性疾病，基本病理变化是全身小血管痉挛，内皮损伤和局部缺血。现在PE发展存在两个阶段的学说被学者普遍认同，第一阶段以胎盘灌注不足引起的氧化应激为核心，第二阶段表现为局部氧化应激诱发全身炎症反应。PE的高危因素包括：年龄 > 40岁、肥胖、初产、家族史或既往PE病史、肾脏疾病、自身免疫性疾病、多胎妊娠等。仅靠以上高危因素来预测PE是有限的，而开发有效的分子标志物，实现对PE的预测及早期诊断，从而为开展症状前治疗提供理论依据，减少子痫前期并发症，改善妊娠结局。本文就血小板/淋巴细胞比值(Blood platelet lymphocyte ratio, PLR)及中性粒细胞/淋巴细胞比值(Neutrophil lymphocyte ratio, NLR)早期预测诊断子痫前期的价值及意义进行综述如下。

Abstract: Pre-eclampsia (PE) is a systemic disease unique to pregnancy. The basic pathological changes are small blood vessel spasm, endothelial injury and ischemia. At present, the theory that there are two stages of PE development is generally accepted by scholars. The first stage is centered on oxidative stress caused by hypoperfusion of the placenta, and the second stage is that local oxidative stress induces systemic inflammation. High-risk factors for PE include: age > 40 years old, obesity, first birth, family history or previous PE history, kidney disease, autoimmune disease, multiple pregnancy, etc. It is limited to predict PE based on the above-mentioned high-risk factors, but the development of effective molecular markers can realize the prediction and early diagnosis of PE, so as to provide a theoretical basis for the development of presymptomatic treatment, reduce preeclampsia complications, and improve pregnancy outcomes. This article reviews the value and significance of platelet/lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) in the early prediction and diagnosis of preeclampsia.