硫化氢经AMPK通路调节自噬保护脓毒症相关性肠黏膜损伤的机制研究
Mechanism Research of Hydrogen Sulfide via AMPK Pathway Mediated Autophagy to Protect Intestinal Mucosal Injury in Sepsis
DOI: 10.12677/ACM.2020.1012456, PDF,    科研立项经费支持
作者: 赫 曼, 柴 琛*：苏州高新区人民医院，江苏 苏州；聂静云, 康富贵：兰州大学第一临床医学院，甘肃 兰州
关键词: 硫化氢；脓毒症；自噬；AMPK信号通路；肠黏膜损伤；Hydrogen Sulfide； Sepsis； Autophagy； AMPK Signal Pathway； Intestinal Mucosal Injury
摘要: 总结硫化氢经AMPK通路调节自噬保护脓毒症相关性肠黏膜损伤的机制。系统检索近年来关于硫化氢经AMPK通路调节自噬保护脓毒症相关性肠黏膜损伤的机制研究的相关文献并进行综述。硫化氢水平与脓毒症相关，可以保护肠黏膜损伤，其机制可能是通过AMPK信号通路介导自噬作用减轻了炎症反应。硫化氢通过AMPK信号通路调控自噬保护肠黏膜，有望成为脓毒症治疗的新靶点。
Abstract: To summarize the mechanism of hydrogen sulfide (H2S) via AMPK pathway mediated autophagy to protect intestinal mucosal injury in sepsis. The relevant literatures in recent years were systematically searched to review the mechanism of H2S via AMPK pathway mediated autophagy in sepsis. The level of H2S is related to sepsis with the protected function of the intestinal mucosal injury. The mechanism may be that H2S mediates autophagy by AMPK signaling to reduce the inflammatory response. H2S mediates autophagy to protect intestinal mucosal injury via AMPK pathway in sepsis, which is expected to become an effective therapeutic target for sepsis.
文章引用：赫曼, 聂静云, 康富贵, 柴琛. 硫化氢经AMPK通路调节自噬保护脓毒症相关性肠黏膜损伤的机制研究[J]. 临床医学进展, 2020, 10(12): 3033-3038. https://doi.org/10.12677/ACM.2020.1012456

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