脊柱转移癌患者PKP术后心理状态和生活质量评价

Effect of Percutaneous Kyphoplasty on Mental State and Quality of Life of Patients with Spinal Metastases

摘要: 目的：观察脊柱转移癌患者经皮椎体后凸成形术(percutaneous kyphoplasty, PKP)后心理状态和生活质量的改善情况。方法：回顾性分析2015年1月到2019年8月采用PKP治疗的97例胸、腰椎转移癌患者。比较分析术前及术后1天、1个月和6月疼痛视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)、抑郁自评量表(SDS)、焦虑自评量表(SAS)及EORTC QLQ-C30生存质量表评分变化。结果：97例患者均成功实施PKP术，手术时间从35 min~95 min不等，平均手术时间为45.37 ± 27.42 min。9例术中出现骨水泥渗漏，但未压迫脊髓或者神经根出现神经症状。术后1天、1个月和6个月VAS评分、ODI指数、SDS评分、SAS评分、EORTC QLQ-C30评分同术前相比明显改善，差异有统计学意义(P < 0.05)。结论：PKP治疗脊柱转移癌可以显著缓解患者疼痛症状、改善抑郁和焦虑情绪、提高生活质量。

Abstract: Objective: To evaluate the effect of percutaneous kyphoplasty (PKP) on mental health and quality of life of patients with spinal metastases. Method: A retrospective analysis which included 97 cases of and thoracolumbar metastases was performed from January 2015 to August 2019, and the changes of pain visual analogue score (VAS), Oswestry dysfunction index (ODI), depression self-rating scale (SDS), Self-rating depression scale (SAS) and cancer patients’ quality of life measurement scale (EORTC QOL-C30) at 1 day, 1 month and 6 months after operation were compared. Result: PKP procedures were successfully performed in all 97 patients, the operation time ranged from 35 min to 95 min, and the average operation time was 45.37 ± 27.42 min. The extravasation of bone cement was found in 9 cases, but there were no neurological symptoms caused by compression of spinal cord or nerve root. In 1 day, 1 month and 6 months after operation, the VAS score, ODI index, SDS score, SAS score and EORTC QLQ-C30 score were significantly lower than that before operation, the differences were statistically significant (P < 0.05). Conclusion: PKP procedures significantly relieve pain symptoms, improve depression and anxiety, and improve quality of life for patients with spinal metastases.