血小板反应蛋白-4在肿瘤研究的进展
Progress of Thrombospondin-4 in Tumor Research
DOI: 10.12677/ACM.2020.1012496, PDF,    科研立项经费支持
作者: 吴建辉, 刘 谦*：天津市第一中心医院泌尿外科，天津
关键词: 细胞外间质；血管生成；肿瘤；纤维化；转移；血小板反应蛋白；Extracellular Matrix (ECM)； Angiogenesis； Cancer； Fibrosis； Migration； Thrombospondin
摘要: 血小板反应蛋白-4 (Thrombospondin-4, THBS-4/TSP-4)于1993年首次被发现，但在此后的很长时间里对该分子的研究没有深入。近年来，PubMed陆续报告确定了TSP-4在心血管和神经系统，炎症，癌症和骨骼肌中许多意想不到的功能。今年的研究重点关注TSP-4在不同组织的生理和病理反应，主要通过基因表达谱的生物信息学分析和分子生物学方法验证。TSP-4的单个分子可以同时与多个细胞受体和细胞外间质(extracellular matrix, ECM)的配体结合，并组织ECM以及细胞与ECM间的相互作用。TSP-4的促血管生成特性可能解释了它在几种癌症中的高表达的原因。TSP-4在癌症组织中的表达增加与癌症进展有关。总的来说，TSP-4在肿瘤防治研究中有望将TSP-4用作肿瘤治疗性靶标，通过抑制血管生成，阻断肿瘤生长、浸润、转移，并减轻疼痛。
Abstract: Thrombospondin-4 (Thrombospondin-4, THBS-4/TSP-4) was first discovered in 1993, but there has been no in-depth research on this molecule for a long time thereafter. In recent years, PubMed has successively reported that TSP-4 has many unexpected functions in the cardiovascular and nervous system, inflammation, cancer and skeletal muscle. This year’s research focuses on the physiological and pathological responses of TSP-4 in different tissues, and is mainly verified by bioinformatics analysis of gene expression profiles and molecular biology methods. A single molecule of TSP-4 can simultaneously bind to multiple cell receptors and extracellular matrix (ECM) ligands, and organize the ECM and the interaction between cells and ECM. The pro-angiogenic properties of TSP-4 may explain its high expression in several cancers. The increased expression of TSP-4 in cancer tissues is associated with cancer progression. In general, TSP-4 is expected to be used as a tumor therapeutic target in tumor prevention and treatment research, by inhibiting angiogenesis, blocking tumor growth, infiltration, and metastasis, and reducing pain.
文章引用：吴建辉, 刘谦. 血小板反应蛋白-4在肿瘤研究的进展[J]. 临床医学进展, 2020, 10(12): 3315-3323. https://doi.org/10.12677/ACM.2020.1012496

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