模拟实际光照的近日节律模型研究

The Circadian Model with the Simulated Actual Illumination

摘要: 为适应外界昼夜周期变化，哺乳动物根据外界环境以及生物体内各种因素变化，通过生物钟的导引来维持其正常运转。已有文献假定每天的光照是固定值，但实际中每天光照是随时间变化的。本文首先建立更加符合实际的光照模型，然后讨论在不同光照强度下腹外侧神经元振子数占总神经元振子数的比值以及神经递质耦合强度的离散程度对生物钟的导引的影响。和在周期光暗循环下相比，在模拟实际光照下的光照强度也对生物钟的导引起决定性作用，腹外侧所占神经元振子比值与神经递质耦合强度的离散程度对生物钟的导引影响也较小，背内侧与腹外侧的分裂现象更少，生物钟导引到外界周期的能力更强。

Abstract: To adapt to the circadian changes of the outside world, mammals regulate the biological clocks to maintain their normal operation according to the changes in the outside environment and various internal biological factors. In the existing literature, the illumination of each day is assumed to be fixed, but it changes over time. This paper firstly establishes a more realistic illumination model, then discusses the influence of the dispersion degree of neurotransmitter coupling strength and the ratio of the number of ventrolateral neurons to the total number of neurons under different light intensity on the entrainment of the SCN. The experimental results show that the illumination intensity plays a decisive role in the entrainment of the SCN, while the ratio of neurons in the ventrolateral region and the dispersion degree of neurotransmitter coupling intensity have little influence on the entrainment of the SCN. Compared with the periodic dark cycle, the illumination intensity also plays a decisive role in the entrainment, and the ratio of the neurons in the ventrolateral area and the dispersion degree of the neurotransmitter coupling intensity also have little influence on it. However, under the simulating actual illumination, there are fewer splits and a stronger ability of the entrainment to the external cycles.