心力衰竭患者血清中Neuronostatin水平及其与心衰严重程度的关系
Serum Neurostatin Level in Patients with Heart Failure and Its Relationship with the Severity of Heart Failure
DOI: 10.12677/ACM.2021.111017, PDF,   
作者: 段传洲：潍坊医学院，临床医学院，山东 潍坊；戴红艳：青岛市市立医院，保健四科，山东 青岛；管 军*：青岛市市立医院，心内科，山东 青岛
关键词: 心力衰竭；Neuronostatin；神经肽；Heart Failure； Neuronostatin； Neuropeptide
摘要: 目的：观察心力衰竭患者血清中neuronostatin水平及其与心衰严重程度的关系，探讨其临床意义。方法：选择其中射血分数降低的62例心衰患者作为实验组，并选取同期非心衰患者72例为对照组，采用酶联免疫吸附试验(ELISA)测定血清中neuronostatin水平。结果：心衰组血清中neuronostatin的水平较非心衰组明显升高，差异有统计学意义(p < 0.05)；心功能III级neuronostatin的水平明显高于II级，心功能IV级neuronostatin的水平明显高于II级，差异均有统计学意义(p < 0.05)；经Spearman相关分析，心衰组NST的水平与不同心功能分级呈正相关(r = 0.649, p < 0.05)；采用ROC曲线，neuronostatin诊断心力衰竭的AUC为0.944。结论：血清中NST的水平升高可能与心力衰竭的发生发展有关，且与心功能的分级呈正相关。
Abstract: Objective: To observe the serum neuronostatin level in patients with heart failure and its relationship with the severity of heart failure, and to explore its clinical significance. Methods: 62 patients with heart failure with reduced ejection fraction were selected as the experimental group, and 72 patients with non-heart failure during the same period were selected as the control group. The level of neuronostatin in serum was determined by enzyme-linked immunosorbent assay (ELISA). Results: The level of neuronostatin in the serum of the heart failure group was significantly higher than that of the non-heart failure group, and the difference was statistically significant (p < 0.05); the level of neuronostatin in cardiac function grade III was significantly higher than that in grade II, and the level of neuronostatin grade IV in cardiac function was significantly higher than that in grade II, and the differences were statistically significant (p < 0.05); Spearman correlation analysis showed that the level of NST in the heart failure group was positively correlated with different cardiac function classifications (r = 0.649, p < 0.05); ROC curve was used, and the AUC of neuronostatin for diagnosing heart failure is 0.944. Conclusion: The increased level of NST in serum may be related to the occurrence and development of heart failure, and is positively related to the grade of heart function.
文章引用：段传洲, 戴红艳, 管军. 心力衰竭患者血清中Neuronostatin水平及其与心衰严重程度的关系[J]. 临床医学进展, 2021, 11(1): 118-124. https://doi.org/10.12677/ACM.2021.111017

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