YAP/TAZ蛋白调控病毒侵染与免疫的研究进展
Research Progress of YAP/TAZ Protein Regulating Virus Infection and Immunity
DOI: 10.12677/HJBM.2021.111002, PDF,    国家自然科学基金支持
作者: 邹 丰, 苟洪伟, 黄金华, 李晨辉, 赵铁军*:浙江师范大学化学与生命科学学院,浙江 金华
关键词: YAP/TAZ蛋白Hippo信号通路病毒侵染免疫发病机理YAP/TAZ Hippo Signaling Pathway Virus Infection Immunity Pathogenesis
摘要: YAP/TAZ介导的Hippo信号通路在生命进程中扮演重要角色,它主要调控器官大小,胚胎发育,细胞增殖以及肿瘤发生等。最新研究发现Hippo信号通路关键蛋白YAP/TAZ在调控人类病毒侵染及免疫反应中发挥非常重要的作用。文章总结了YAP/TAZ蛋白的病理学特征,重点介绍YAP/TAZ蛋白在调控人类病毒侵染、复制、诱发疾病以及免疫调控中的功能及其机理,以期为病毒致病机制研究及治疗手段开发提供新的见解和思路。
Abstract: Accumulating evidence showed that YAP/TAZ mediated Hippo pathway plays a critical role in bio-logical processes, including the control of organ size, embryonic development, cell proliferation, and cancer development. The Hippo signaling pathway key protein YAP/TAZ has been found to play a very important role in human virus infection and immunity. This paper summarizes the pathologic characteristics of YAP/TAZ protein, and focuses on the functions and mechanisms of YAP/TAZ pro-tein in the regulation of human virus infection, replication, disease induction and immune regula-tion. It might give new insights into the research of viral disease and its therapy.
文章引用:邹丰, 苟洪伟, 黄金华, 李晨辉, 赵铁军. YAP/TAZ蛋白调控病毒侵染与免疫的研究进展[J]. 生物医学, 2021, 11(1): 8-13. https://doi.org/10.12677/HJBM.2021.111002

参考文献

[1] Zhao, B., Li, L., Lei, Q., et al. (2010) The Hippo-YAP Pathway in Organ Size Control and Tumorigenesis: An Updated Version. Genes & Development, 24, 862-874. [Google Scholar] [CrossRef] [PubMed]
[2] Zhang, Q., Meng, F., Chen, S., et al. (2017) Hippo Signalling Governs Cytosolic Nucleic Acid Sensing through YAP/TAZ-Mediated TBK1 Blockade. Nature Cell Biology, 19, 362-374. [Google Scholar] [CrossRef] [PubMed]
[3] Hong, L., Li, X., Zhou, D., et al. (2018) Role of Hippo Signaling in Regulating Immunity. Cellular & Molecular Immunology, 15, 1003-1009. [Google Scholar] [CrossRef] [PubMed]
[4] Taha, Z., van Rensburg, H.J.J. and Yang, X. (2018) The Hippo Pathway: Immunity and Cancer. Cancers (Basel), 10, 94. [Google Scholar] [CrossRef] [PubMed]
[5] Piccolo, S., Dupont, S. and Cordenonsi, M. (2014) The Biology of YAP/TAZ: Hippo Signaling and Beyond. Physiological Reviews, 94, 1287-1312. [Google Scholar] [CrossRef] [PubMed]
[6] Zhao, B., Wei, X., Li, W., et al. (2007) Inactivation of YAP Oncoprotein by the Hippo Pathway Is Involved in Cell Contact Inhibition and Tissue Growth Control. Genes & Development, 21, 2747-2761. [Google Scholar] [CrossRef] [PubMed]
[7] Boggiano, J.C., Vanderzalm, P.J. and Fehon, R.G. (2011) Tao-1 Phosphorylates Hippo/MST Kinases to Regulate the Hippo-Salvador-Warts Tumor Suppressor Pathway. Developmental Cell, 21, 888-895. [Google Scholar] [CrossRef] [PubMed]
[8] Oka, T., Mazack, V. and Sudol, M. (2008) Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-Associated Protein (YAP). Journal of Biological Chemistry, 283, 27534-27546. [Google Scholar] [CrossRef
[9] Ni, L., Zheng, Y., Hara, M., Pan, D. and Luo, X. (2015) Structural Basis for Mob1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling. Genes & Development, 29, 1416-1431. [Google Scholar] [CrossRef] [PubMed]
[10] Yin, F., Yu, J., Zheng, Y., et al. (2013) Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2. Cell, 154, 1342-1355. [Google Scholar] [CrossRef] [PubMed]
[11] Yu, F.X., Zhao, B., Panupinthu, N., et al. (2012) Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling. Cell, 150, 780-791. [Google Scholar] [CrossRef] [PubMed]
[12] Yu, F.X., Zhang, Y., Park, H.W., et al. (2013) Protein Kinase A Activates the Hippo Pathway to Modulate Cell Proliferation and Differentiation. Genes & Development, 27, 1223-1232. [Google Scholar] [CrossRef] [PubMed]
[13] Meng, Z., Moroishi, T., Mottier-Pavie, V., et al. (2015) MAP4K Family Kinases Act in Parallel to MST1/2 to Activate LATS1/2 in the Hippo Pathway. Nature Communications, 6, Article No. 8357. [Google Scholar] [CrossRef] [PubMed]
[14] Zhao, B., Li, L., Tumaneng, K., Wang, C.Y. and Guan, K.L. (2010) A Coordinated Phosphorylation by Lats and CK1 Regulates YAP Stability through SCFβ-TRCP. Genes & Development, 24, 72-85. [Google Scholar] [CrossRef] [PubMed]
[15] Zhao, B., Ye, X., Yu, J., et al. (2008) TEAD Mediates YAP-Dependent Gene Induction and Growth Control. Genes & Development, 22, 1962-1971. [Google Scholar] [CrossRef] [PubMed]
[16] Moroishi, T., Hansen, C.G. and Guan, K.L. (2015) The Emerging Roles of YAP and TAZ in Cancer. Nature Reviews Cancer, 15, 73-79. [Google Scholar] [CrossRef] [PubMed]
[17] Kang, W., Cheng, A.S., Yu, J., et al. (2016) Emerging Role of Hippo Pathway in Gastric and Other Gastrointestinal Cancers. World Journal of Gastroenterology, 22, 1279-1288. [Google Scholar] [CrossRef] [PubMed]
[18] Zhang, L., Yang, S., Chen, X., et al. (2015) The Hippo Pathway Effector YAP Regulates Motility, Invasion, and Castration-Resistant Growth of Prostate Cancer Cells. Molecular and Cellular Biology, 35, 1350-1362. [Google Scholar] [CrossRef
[19] Harvey, K.F., Zhang, X. and Thomas, D.M. (2013) The Hippo Pathway and Human Cancer. Nature Reviews Cancer, 13, 246-257. [Google Scholar] [CrossRef] [PubMed]
[20] Xia, Y., Chang, T., Wang, Y., et al. (2014) YAP Promotes Ovarian Cancer Cell Tumorigenesis and Is Indicative of a Poor Prognosis for Ovarian Cancer Patients. PLoS One, 9, e91770. [Google Scholar] [CrossRef] [PubMed]
[21] Gomez, M., Gomez, V. and Hergovich, A. (2014) The Hippo Pathway in Disease and Therapy: Cancer and Beyond. Clinical and Translational Medicine, 3, 22. [Google Scholar] [CrossRef] [PubMed]
[22] Zhang, T., Zhang, J., You, X., et al. (2012) Hepatitis B Virus X Protein Modulates Oncogene Yes-Associated Protein by CREB to Promote Growth of Hepatoma Cells. Hepatology, 56, 2051-2059. [Google Scholar] [CrossRef] [PubMed]
[23] Liu, P., Zhang, H., Liang, X., et al. (2015) HBV preS2 Promotes the Expression of TAZ via miRNA-338-3p to Enhance the Tumorigenesis of Hepatocellular Carcinoma. Oncotarget, 6, 29048-29059. [Google Scholar] [CrossRef] [PubMed]
[24] Wang, Y., Fang, R., Cui, M., et al. (2017) The Oncoprotein HBXIP Up-Regulates YAP through Activation of Transcription Factor c-Myb to Promote Growth of Liver Cancer. Cancer Letters, 385, 234-242. [Google Scholar] [CrossRef] [PubMed]
[25] He, J., Tang, F., Liu, L., et al. (2017) Positive Regulation of TAZ Expression by EBV-LMP1 Contributes to Cell Proliferation and Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma. Oncotarget, 8, 52333-52344. [Google Scholar] [CrossRef] [PubMed]
[26] Garcia, G., Paul, S., Beshara, S., et al. (2020) Hippo Signaling Pathway Has a Critical Role in Zika Virus Replication and in the Pathogenesis of Neuroinflammation. The American Journal of Pathology, 190, 844-861. [Google Scholar] [CrossRef] [PubMed]
[27] He, C., Mao, D., Hua, G., et al. (2015) The Hippo/YAP Pathway Interacts with EGFR Signaling and HPV Oncoproteins to Regulate Cervical Cancer Progression. EMBO Molecular Medicine, 7, 1426-1449. [Google Scholar] [CrossRef] [PubMed]
[28] Strickland, S.W., Brimer, N., Lyons, C., et al. (2018) Human Papillomavirus E6 Interaction with Cellular PDZ Domain Proteins Modulates YAP Nuclear Localization. Virology, 516, 127-138. [Google Scholar] [CrossRef] [PubMed]
[29] Liu, G., Yu, F.X., Kim, Y.C., et al. (2015) Kaposi Sarcoma-Associated Herpesvirus Promotes Tumorigenesis by Modulating the Hippo Pathway. Oncogene, 34, 3536-3546. [Google Scholar] [CrossRef] [PubMed]
[30] Wang, S., Xie, F., Chu, F., et al. (2017) YAP Antagonizes Innate Antiviral Immunity and Is Targeted for Lysosomal Degradation through IKKɛ-Mediated Phosphorylation. Nature Immunology, 18, 733-743. [Google Scholar] [CrossRef] [PubMed]
[31] Kim, N., Park, Y.Y., Joo, C.H. and Kim, H.S. (2018) Relief of YAP-Mediated Inhibition by IKKɛ Promotes Innate Antiviral Immunity. Cellular & Molecular Immunology, 15, 642-644. [Google Scholar] [CrossRef] [PubMed]
[32] White, S.M., Murakami, S. and Yi, C. (2019) The Complex Entanglement of Hippo-Yap/Taz Signaling in Tumor Immunity. Oncogene, 38, 2899-2909. [Google Scholar] [CrossRef] [PubMed]
[33] Feng, J., Gou, J., Jia, J., Yi, T., Cui, T. and Li, Z. (2016) Verteporfin, a Suppressor of YAP-TEAD Complex, Presents Promising Antitumor Properties on Ovarian Cancer. OncoTargets and Therapy, 9, 5371-5381. [Google Scholar] [CrossRef
[34] Zhang, W., Gao, Y., Li, P., et al. (2014) VGLL4 Functions as a New Tumor Suppressor in Lung Cancer by Negatively Regulating the YAP-TEAD Transcriptional Complex. Cell Research, 24, 331-343. [Google Scholar] [CrossRef] [PubMed]