空腹血糖与间质性肺疾病关系研究

Study on the Relationship between Fasting Blood Glucose and Interstitial Lung Disease

摘要: 目的：探讨高血糖是否为间质性肺疾病危险因素，以及高血糖是否导致间质性肺疾病患者预后不良。方法：收集青岛大学附属医院2019年1月~2019年12月住院患者病例资料，间质性肺疾病者为实验组(150例)，无间质性疾病者为对照组(300例)，比较两组患者空腹血糖是否存在差异；将间质性肺疾病患者按空腹血糖分为高血糖组(51例)和正常血糖组(99例)，比较两组患者血气分析、六分钟步行距离、肺功能、住院时长、死亡率等预后指标。结果：1) 间质性肺疾病组空腹血糖水平明显高于无间质性肺疾病组(p < 0.05)。2) 高血糖组与正常血糖组比较，氧分压、二氧化碳分压、氧饱和度、FVC、FEV1、DLCO、PEF、住院时长、死亡率，差异具有统计学意义(p < 0.05)；年龄、BMI、六分钟步行距离，差异无统计学意义(p > 0.05)。3) 皮尔逊相关分析结果显示，空腹血糖水平与住院时长(r = 0.232, p < 0.05)呈正相关，与氧分压(r = −0.311, p < 0.05)、氧饱和度(r = −0.255, p < 0.05)、FVC (r = −0.312, p < 0.05)、FEV1 (r = −0.301, p < 0.05)、DLCO (r = −0.222, p < 0.05)、PEF (r = −0.627, p < 0.05)呈负相关。结论：高血糖可致使肺部受损，是导致ILD的独立危险因素之一。ILD合并高血糖会加重肺限制性功能障碍及非弥散功能障碍，增长住院时间，增高患者死亡率。

Abstract: Objective: To explore whether hyperglycemia is a risk factor for interstitial lung disease, and whether hyperglycemia leads to poor prognosis in patients with interstitial lung disease. Methods: The data of hospitalized patients from January 2019 to December 2019 in the Affiliated Hospital of Qingdao University were collected. Patients with interstitial lung disease were the experimental group (150 cases), and those without interstitial disease were the control group (300 cases). The difference in fasting blood glucose between patients of the two groups was compared; the patients with interstitial lung disease were divided into hyperglycemia group (51 cases) and normal blood glucose group (99 cases) according to fasting blood glucose, and prognostic indicators such as blood gas analysis, six-minute walking distance, lung function, length of stay, and mortality rates in the two groups were compared. Results: 1) The fasting blood glucose level in the interstitial lung disease group was significantly higher than that in the non-interstitial lung disease group (p < 0.05). 2) Compared with the normal blood glucose group (99 cases), the hyperglycemia group (51 cases) had lower oxygen partial pressure, carbon dioxide partial pressure, oxygen saturation, FVC, FEV1, DLCO, PEF, longer hospital stay, and higher mortality rates; the difference is statistically significant (p < 0.05); there is no statistically significant difference in age and BMI (p > 0.05). 3) Pearson correlation analysis results show that fasting blood glucose level is positively correlated with length of hospital stay (r = 0.232, p < 0.05), and negatively correlated with oxygen partial pressure (r = −0.311, p < 0.05), oxygen saturation (r = −0.255, p < 0.05), FVC (r = −0.312, p < 0.05), FEV1 (r = −0.301, p < 0.05), DLCO (r = −0.222, p < 0.05), PEF (r = −0.627, p < 0.05). Conclusion: Hyperglycemia can cause lung damage and is one of the independent risk factors for ILD. ILD combined with hyperglycemia can aggravate restrictive pulmonary dysfunction and non-diffuse dysfunction, increase hospital stay, and increase patient mortality.