|
[1]
|
Bostrom, P., et al. (2012) A PGC1-Alpha-Dependent Myokine That Drives Brown-Fat-Like Development of White Fat and Thermogenesis. Nature, 481, 463-468. [Google Scholar] [CrossRef] [PubMed]
|
|
[2]
|
Huh, J.Y., et al. (2014) Irisin in Response to Acute and Chronic Whole-Body Vibration Exercise in Humans. Metabolism, 63, 918-921. [Google Scholar] [CrossRef] [PubMed]
|
|
[3]
|
Dun, S.L., et al. (2013) Irisin-Immunoreactivity in Neural and Non-Neural Cells of the Rodent. Neuroscience, 240, 155-162. [Google Scholar] [CrossRef] [PubMed]
|
|
[4]
|
Aydin, S., et al. (2015) Effect of Carnosine Supplementa-tion on Apoptosis and Irisin, Total Oxidant and Antioxidants Levels in the Serum, Liver and Lung Tissues in Rats Ex-posed to Formaldehyde Inhalation. Peptides, 64, 14-23. [Google Scholar] [CrossRef] [PubMed]
|
|
[5]
|
Moreno-Navarrete, J.M., et al. (2013) Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association with Obesity and Insulin Resistance. The Journal of Clinical Endocrinology and Metabolism, 98, E769-E778. [Google Scholar] [CrossRef] [PubMed]
|
|
[6]
|
Roca-Rivada, A., et al. (2013) FNDC5/Irisin Is Not Only a Myokine But Also an Adipokine. PLoS ONE, 8, e60563. [Google Scholar] [CrossRef] [PubMed]
|
|
[7]
|
Aydin, S., et al. (2014) A Comprehensive Immunohistochemical Examination of the Distribution of the Fat-Burning Protein Irisin in Biological Tissues. Peptides, 61, 130-136. [Google Scholar] [CrossRef] [PubMed]
|
|
[8]
|
Giralt, M. and Villarroya, F. (2013) White, Brown, Beige/Brite: Different Adipose Cells for Different Functions? Endocrinology, 154, 2992-3000. [Google Scholar] [CrossRef] [PubMed]
|
|
[9]
|
Jastroch, M., et al. (2010) Mitochondrial Proton and Electron Leaks. Essays in Biochemistry, 47, 53-67. [Google Scholar] [CrossRef] [PubMed]
|
|
[10]
|
Seale, P., et al. (2008) PRDM16 Controls a Brown Fat/Skeletal Muscle Switch. Nature, 454, 961-967. [Google Scholar] [CrossRef] [PubMed]
|
|
[11]
|
Timmons, J.A., et al. (2007) Myogenic Gene Expression Signature Es-tablishes That Brown and White Adipocytes Originate from Distinct Cell Lineages. Proceedings of the National Academy of Sciences of the United States of America, 104, 4401-4406. [Google Scholar] [CrossRef] [PubMed]
|
|
[12]
|
Young, P., Arch, J.R. and Ashwell, M. (1984) Brown Adipose Tissue in the Parametrial Fat Pad of the Mouse. FEBS Letters, 167, 10-14. [Google Scholar] [CrossRef] [PubMed]
|
|
[13]
|
Perakakis, N., et al. (2017) Physiology and Role of Irisin in Glucose Homeostasis. Nature Reviews Endocrinology, 13, 324-337. [Google Scholar] [CrossRef] [PubMed]
|
|
[14]
|
Roberts, M.D., et al. (2013) Elevated Skeletal Muscle Irisin Precur-sor FNDC5 mRNA in Obese OLETF Rats. Metabolism, 62, 1052-1056. [Google Scholar] [CrossRef] [PubMed]
|
|
[15]
|
Huh, J.Y., et al. (2012) FNDC5 and Irisin in Humans: I. Pre-dictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise. Metabolism, 61, 1725-1738. [Google Scholar] [CrossRef] [PubMed]
|
|
[16]
|
Ellefsen, S., et al. (2014) Irisin and FNDC5: Effects of 12-Week Strength Training, and Relations to Muscle Phenotype and Body Mass Composition in Untrained Women. Eu-ropean Journal of Applied Physiology, 114, 1875-1888. [Google Scholar] [CrossRef] [PubMed]
|
|
[17]
|
Daskalopoulou, S.S., et al. (2014) Plasma Irisin Levels Progres-sively Increase in Response to Increasing Exercise Workloads in Young, Healthy, Active Subjects. European Journal of Endocrinology, 171, 343-352. [Google Scholar] [CrossRef]
|
|
[18]
|
Jedrychowski, M.P., et al. (2015) Detection and Quantitation of Circu-lating Human Irisin by Tandem Mass Spectrometry. Cell Metabolism, 22, 734-740. [Google Scholar] [CrossRef] [PubMed]
|
|
[19]
|
Liu, J.J., et al. (2013) Lower Circulating Irisin Is Associated with Type 2 Diabetes Mellitus. Journal of Diabetic Complications, 27, 365-369. [Google Scholar] [CrossRef] [PubMed]
|
|
[20]
|
Choi, Y.K., et al. (2013) Serum Irisin Levels in New-Onset Type 2 Diabetes. Diabetes Research and Clinical Practice, 100, 96-101. [Google Scholar] [CrossRef] [PubMed]
|
|
[21]
|
Kurdiova, T., et al. (2014) Effects of Obesity, Diabetes and Ex-ercise on Fndc5 Gene Expression and Irisin Release in Human Skeletal Muscle and Adipose Tissue: In Vivo and in Vitro Studies. The Journal of Physiology, 592, 1091-1107. [Google Scholar] [CrossRef] [PubMed]
|
|
[22]
|
Zhang, M., et al. (2014) The Association of New Inflammatory Markers with Type 2 Diabetes Mellitus and Macrovascular Complications: A Preliminary Study. European Review for Medical and Pharmacological Sciences, 18, 1567-1572.
|
|
[23]
|
Liu, J.J., et al. (2014) Relationship between Circulating Irisin, Renal Function and Body Composition in Type 2 Diabetes. Journal of Diabetic Complications, 28, 208-213. [Google Scholar] [CrossRef] [PubMed]
|
|
[24]
|
Ates, I., et al. (2017) Factors Associated with Increased Irisin Levels in the Type 1 Diabetes Mellitus. Endocrine Regulations, 51, 1-7. [Google Scholar] [CrossRef] [PubMed]
|
|
[25]
|
Espes, D., Lau, J. and Carlsson, P.O. (2015) Increased Levels of Irisin in People with Long-Standing Type 1 Diabetes. Diabetic Medicine, 32, 1172-1176. [Google Scholar] [CrossRef] [PubMed]
|
|
[26]
|
Huerta, A.E., et al. (2015) Circulating Irisin and Glucose Metabolism in Overweight/Obese Women: Effects of Alpha-Lipoic Acid and Eicosapentaenoic Acid. Journal of Physiology and Bio-chemistry, 71, 547-558. [Google Scholar] [CrossRef] [PubMed]
|
|
[27]
|
Yang, M., et al. (2014) Circulating Levels of Irisin in Mid-dle-Aged First-Degree Relatives of Type 2 Diabetes Mellitus—Correlation with Pancreatic Beta-Cell Function. Dia-betology & Metabolic Syndrome, 6, 133. [Google Scholar] [CrossRef] [PubMed]
|
|
[28]
|
Piya, M.K., et al. (2014) The Identification of Irisin in Human Cere-brospinal Fluid: Influence of Adiposity, Metabolic Markers, and Gestational Diabetes. American Journal of Physiolo-gy-Endocrinology and Metabolism, 306, E512-E518. [Google Scholar] [CrossRef] [PubMed]
|
|
[29]
|
Kuzmicki, M., et al. (2014) Serum Irisin Concentration in Women with Gestational Diabetes. Gynecological Endocrinology, 30, 636-639. [Google Scholar] [CrossRef] [PubMed]
|
|
[30]
|
Usluogullari, B., et al. (2017) Role of Serum Levels of Irisin and Oxidative Stress Markers in Pregnant Women with and without Gestational Diabetes. Gynecological Endocrinology, 33, 405-407. [Google Scholar] [CrossRef] [PubMed]
|
|
[31]
|
Zhao, L., et al. (2015) Circulating Irisin Is Lower in Gesta-tional Diabetes Mellitus. Endocrine Journal, 62, 921-926. [Google Scholar] [CrossRef]
|
|
[32]
|
Yuksel, M.A., et al. (2014) Maternal Serum and Fetal Cord Blood Irisin Levels in Gestational Diabetes Mellitus. Diabetes Research and Clinical Practice, 104, 171-175. [Google Scholar] [CrossRef] [PubMed]
|
|
[33]
|
Ural, U.M., et al. (2016) Alteration of Maternal Serum Irisin Levels in Gestational Diabetes Mellitus. Ginekologia Polska, 87, 395-398. [Google Scholar] [CrossRef]
|
|
[34]
|
Ebert, T., et al. (2014) Serum Levels of Irisin in Gestational Diabetes Mellitus during Pregnancy and after Delivery. Cytokine, 65, 153-158. [Google Scholar] [CrossRef] [PubMed]
|
|
[35]
|
Liu, T.Y., et al. (2015) Irisin Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis via the PI3K/Akt Pathway in Type 2 Diabetic Mice and Hepatocytes. Clinical Science, 129, 839-850. [Google Scholar] [CrossRef]
|
|
[36]
|
Duan, H., et al. (2016) Anti-Diabetic Activity of Recombinant Irisin in STZ-Induced Insulin-Deficient Diabetic Mice. International Journal of Biological Macromolecules, 84, 457-463. [Google Scholar] [CrossRef] [PubMed]
|
|
[37]
|
Xin, C., et al. (2016) Irisin Improves Fatty Acid Oxidation and Glucose Utilization in Type 2 Diabetes by Regulating the AMPK Signaling Pathway. International Journal of Obesity (London), 40, 443-451. [Google Scholar] [CrossRef] [PubMed]
|
|
[38]
|
Yang, Z., et al. (2015) Decreased Irisin Secretion Contributes to Muscle Insulin Resistance in High-Fat Diet Mice. International Journal of Clinical and Experimental Pathology, 8, 6490-6497.
|
|
[39]
|
Zhu, D., et al. (2015) Irisin Improves Endothelial Function in Type 2 Diabetes through Reducing Oxi-dative/Nitrative Stresses. Journal of Molecular and Cellular Cardiology, 87, 138-147. [Google Scholar] [CrossRef] [PubMed]
|
|
[40]
|
Liu, S., et al. (2017) Effects and Underlying Mechanisms of Irisin on the Proliferation and Apoptosis of Pancreatic Beta Cells. PLoS ONE, 12, e0175498. [Google Scholar] [CrossRef] [PubMed]
|
|
[41]
|
Natalicchio, A., et al. (2017) The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic Beta-Cell Survival and Insulin Secretion. Diabetes, 66, 2849-2856. [Google Scholar] [CrossRef] [PubMed]
|
|
[42]
|
Cai, C., et al. (2017) Gene Location, Expression, and Function of FNDC5 in Meishan Pigs. Scientific Reports, 7, Article No. 7886. [Google Scholar] [CrossRef] [PubMed]
|
|
[43]
|
Xiong, X.Q., et al. (2015) FNDC5 Overexpression and Irisin Ameliorate Glucose/Lipid Metabolic Derangements and Enhance Lipolysis in Obesity. Biochimica et Biophysica Acta, 1852, 1867-1875. [Google Scholar] [CrossRef] [PubMed]
|
|
[44]
|
Rabiee, F., et al. (2014) Induced Expression of Fndc5 Signifi-cantly Increased Cardiomyocyte Differentiation Rate of Mouse Embryonic Stem Cells. Gene, 551, 127-137. [Google Scholar] [CrossRef] [PubMed]
|
|
[45]
|
Nazem, S., et al. (2018) Fndc5 Knockdown Induced Suppression of Mitochondrial Integrity and Significantly Decreased Cardiac Differentiation of Mouse Embryonic Stem Cells. Journal of Cellular Biochemistry, 119, 4528-4539. [Google Scholar] [CrossRef] [PubMed]
|
|
[46]
|
Ghahrizjani, F.A., et al. (2015) Enhanced Expression of FNDC5 in Human Embryonic Stem Cell-Derived Neural Cells Along with Relevant Embryonic Neural Tissues. Gene, 557, 123-129. [Google Scholar] [CrossRef] [PubMed]
|
|
[47]
|
Tanhaei, S., et al. (2018) RNA/Protein Discordant Expression of Fndc5 in Central Nervous System Is Likely to Be Mediated through microRNAs. DNA and Cell Biology, 37, 373-380. [Google Scholar] [CrossRef] [PubMed]
|
|
[48]
|
Staiger, H., et al. (2013) Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived “Browning” Factor Irisin, Determines Insulin Sensitivity. PLoS ONE, 8, e61903. [Google Scholar] [CrossRef] [PubMed]
|
|
[49]
|
Tang, S., et al. (2014) An Interaction between a FNDC5 Variant and Obesity Modulates Glucose Metabolism in a Chinese Han Population. PLoS ONE, 9, e109957. [Google Scholar] [CrossRef] [PubMed]
|
|
[50]
|
Varela-Rodriguez, B.M., et al. (2016) FNDC5 Expression and Circulating Irisin Levels Are Modified by Diet and Hormonal Conditions in Hypothalamus, Adipose Tissue and Muscle. Scientific Reports, 6, Article No. 29898. [Google Scholar] [CrossRef] [PubMed]
|
|
[51]
|
Wrann, C.D., et al. (2013) Exercise Induces Hippocampal BDNF through a PGC-1alpha/FNDC5 Pathway. Cell Metabolism, 18, 649-659. [Google Scholar] [CrossRef] [PubMed]
|
|
[52]
|
Ruan, Q., et al. (2018) Detection and Quantitation of Irisin in Hu-man Cerebrospinal Fluid by Tandem Mass Spectrometry. Peptides, 103, 60-64. [Google Scholar] [CrossRef] [PubMed]
|
|
[53]
|
Forouzanfar, M., et al. (2015) Fndc5 Overexpression Facilitat-ed Neural Differentiation of Mouse Embryonic Stem Cells. Cell Biology International, 39, 629-637. [Google Scholar] [CrossRef] [PubMed]
|
|
[54]
|
Hashemi, M.S., et al. (2013) Fndc5 Knockdown Significantly Decreased Neural Differentiation Rate of Mouse Embryonic Stem Cells. Neuroscience, 231, 296-304. [Google Scholar] [CrossRef] [PubMed]
|
|
[55]
|
Vaynman, S., Ying, Z. and Gomez-Pinilla, F. (2004) Hip-pocampal BDNF Mediates the Efficacy of Exercise on Synaptic Plasticity and Cognition. European Journal of Neuro-science, 20, 2580-2590. [Google Scholar] [CrossRef] [PubMed]
|
|
[56]
|
Olesen, J., Kiilerich, K. and Pilegaard, H. (2010) PGC-1alpha-Mediated Adaptations in Skeletal Muscle. Pflügers Archiv, 460, 153-162. [Google Scholar] [CrossRef] [PubMed]
|
|
[57]
|
Kuster, O.C., et al. (2017) Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway. Journal of Alzheimer’s Disease, 59, 1097-1111. [Google Scholar] [CrossRef]
|
|
[58]
|
Belviranli, M., et al. (2016) The Relationship between Brain-Derived Neurotrophic Factor, Irisin and Cognitive Skills of Endurance Athletes. The Physician and Sportsmedicine, 44, 290-296. [Google Scholar] [CrossRef] [PubMed]
|
|
[59]
|
Fagundo, A.B., et al. (2016) Modulation of Irisin and Phys-ical Activity on Executive Functions in Obesity and Morbid Obesity. Scientific Reports, 6, Article No. 30820. [Google Scholar] [CrossRef] [PubMed]
|
|
[60]
|
Crujeiras, A.B., Pardo, M. and Casanueva, F.F. (2015) Irisin: “Fat” or Ar-tefact. Clinical Endocrinology, 82, 467-474. [Google Scholar] [CrossRef] [PubMed]
|
|
[61]
|
Elbelt, U., Hofmann, T. and Stengel, A. (2013) Irisin: What Promise Does It Hold? Current Opinion in Clinical Nutrition & Metabolic Care, 16, 541-547. [Google Scholar] [CrossRef]
|
|
[62]
|
Hofmann, T., Elbelt, U. and Stengel, A. (2014) Irisin as a Muscle-Derived Hormone Stimulating Thermogenesis—A Critical Update. Peptides, 54, 89-100. [Google Scholar] [CrossRef] [PubMed]
|
|
[63]
|
Polyzos, S.A. and Mantzoros, C.S. (2015) An Update on the Validity of Irisin Assays and the Link between Irisin and Hepatic Metabolism. Metabolism, 64, 937-942. [Google Scholar] [CrossRef] [PubMed]
|
|
[64]
|
Polyzos, S.A., Mathew, H. and Mantzoros, C.S. (2015) Irisin: A True, Circulating Hormone. Metabolism, 64, 1611-1618. [Google Scholar] [CrossRef] [PubMed]
|