老年II型糖尿病患者血清胱抑素C与心室重构的相关性

Correlation between Serum Cystatin C and Ventricular Remodeling in Elderly Type 2 Diabetic Patients

摘要: 目的：探讨老年II型糖尿病患者血清胱抑素C与心室重构的相关性。方法：筛选就诊于我院的老年II型糖尿病患者140例(年龄均 ≥ 65岁)，检测患者血清胱抑素C浓度，根据老年II型糖尿病患者血清胱抑素C浓度，将全部患者分为胱抑素C正常组(胱抑素C ≤ 1.03 mg/L) 60例，胱抑素C升高组(胱抑素C > 1.03 mg/L) 71例。使用超声心动图测量两组患者左室射血分数(left ventricular ejection fraction, EF)、左房内径(left atrial diameter, LAD)、左室舒张末内径(left ventricular end-diastolic diameter, LVD)、左室后壁厚度(left ventricular posterior wall thickness, LVPWT)、室间隔厚度(ventricular septal thickness, IVST)并计算左室质量指数(left ventricular mass index, LVMI)。对这些指标进行组间比较，并分析血清胱抑素C与心室重构的相关性。结果：与胱抑素C正常组相比，胱抑素C升高组的LVMI、IVST显著增高(P < 0.01)。相关分析显示：血清胱抑素C含量与LVMI、IVST呈正相关，并具有统计学意义(P < 0.01)。结论：血清胱抑素C浓度与老年II型糖尿病患者心室重构具有显著相关性，可作为衡量II型糖尿病患者心室重构程度的一项指标。

Abstract: Objective: To explore the correlation between serum cystatin C and ventricular remodeling in elderly type 2 diabetic patients. Method: 140 elderly patients with type 2 diabetes who admitted to our hospital (age ≥ 65 years old) were screened, the serum cystatin C level of whom was measured. According to the patients’ serum cystatin C concentration, all patients were divided into the normal cystatin C group (cystatin C ≤ 1.03 mg/L) 60 cases and the higher cystatin C group (cystatin C > 1.03 mg/L) 71 cases. Left ventricular ejection fraction (EF), left atrial diameter (LAD), left ventricular end-diastolic diameter (LVD), left ventricular posterior wall thickness (LVPWT), and ventricular septal thickness (IVST) were measured by echocardiography in both groups, then left ventricular mass index (LVMI) was calculated. These indexes were compared between groups, and the correlation between serum cystatin C and ventricular remodeling was analyzed. Results: Compared to the normal cystatin C group, the LVMI and IVST of the higher cystatin C group were significantly increased (P < 0.01). Correlation analysis showed that serum cystatin C content was positively correlated with LVMI and IVST, and it was statistically significant (P < 0.01). Conclusion: The serum cystatin C level and ventricular remodeling in elderly type 2 diabetic patients have significant correlation. Cystatin C can be used as an index to measure the degree of ventricular remodeling in elderly type 2 diabetic patients.