基于脑分割技术对性别与年龄在脑结构体积中影响的研究进展

Research Progress on the Influence of Gender and Age in Brain Structure Volume Based on Brain Segmentation Technology

摘要: 随着社会发展，现代中国的老年化问题日益加重，正常人老年化过程中常导致神经退行性改变，引起灰质及白质的体积不同改变。现有研究证明脑萎缩与多种疾病相关，有的疾病甚至有直接相关，对我国的老年化群体及家庭造成很大负担。明确健康人大脑灰质、白质结构随年龄变化特点，从而进一步探索大脑退化的规律成为近些年国内外神经影像学科的重点研究问题。当进行脑体积神经影像分析时，年龄、性别和头部大小(颅内容积)是最常见的变量，所以探究这些因素的影响成为当前研究的热点。本综述多选取pubmed近五年脑容积改变相关外文文献，分析不同性别健康人脑灰、白质体积随年龄的变化特点，从而进一步探索脑老化变化规律。

Abstract: With the development of society, the problem of aging in modern China is becoming more and more serious. In the process of aging, normal people often lead to neurodegenerative changes, resulting in different volumes of gray matter and white matter. Existing studies have proved that brain atrophy is related to a variety of diseases, and some diseases are even directly related, which causes a great burden to the aging groups and families in our country. In recent years, it has become a key research issue in neuroimaging field at home and abroad to clarify the characteristics of changes of gray matter and white matter structure in healthy people’s brain with age, so as to further explore the law of brain degeneration. When brain volume neuroimaging analysis is carried out, age, sex and head size (intracranial volume) are the most common variables, so exploring the influence of these factors has become the focus of the current research. This review mainly selects the foreign literature related to the changes of brain volume in the past five years of pubmed, and analyzes the characteristics of brain gray and white matter volume changes with age in healthy people of different genders, so as to further explore the changes of brain aging.