咳喘六味合剂联合西医常规疗法治疗肥胖型哮喘(外寒内饮证)急性发作期临床疗效观察

Clinical Effect Observation of Kechuan Liuwei Mixture Combined with Western Medicine Routine Therapy on Obesity Asthma of Cold Type in Acute Attack Period

摘要: 目的：观察咳喘六味合剂联合西医常规疗法治疗肥胖型哮喘(外寒内饮证)急性发作期患者的临床疗效。方法：将78例肥胖型哮喘(外寒内饮证)急性发作期患者随机分为对照组与治疗组，对照组患者给予平喘对症等西药基础治疗；治疗组患者在给予基础治疗的同时加用咳喘六味合剂治疗，疗程均为2周。观察两组患者治疗前后的中医证候积分、哮喘控制水平测试量表(ACT)，生存质量评分(AQLQ)、肺功能[用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、最大呼气流速(PEF)]的变化。结果：经治后对照组中医症候总有效率为75%，治疗组为88.1%，两组比较有统计学差异(P < 0.05)；两组中医证候积分(包括喘息、气短、咳嗽、咯痰、哮鸣音)治疗后均较前改善(P < 0.05)，且在改善喘息、气短、咳嗽、咯痰方面，治疗组优于对照组(P < 0.05)；两组治疗后AQLQ评分均较前改善，且治疗组改善程度优于对照组(P < 0.05)；两组治疗后ACT评分均较前好转，治疗组改善明显优于对照组(P < 0.01)；两组治疗后肺功能FVC、FEV1、PEF均较前改善(P < 0.05)，且治疗组改善FEV1、PEF更优于对照组(P < 0.05)。结论：咳喘六味合剂联合西医常规疗法治疗肥胖型哮喘(外寒内饮证)急性发作期患者临床疗效明显，可明显减轻临床症状，更好地控制哮喘发作，提高生存质量，改善肺功能，值得临床进一步推广。

Abstract: Objective: To observe the clinical effect of Kechuan Liuwei Mixture combined with western medicine routine therapy on obese asthma of cold type in acute attack period. Methods: 78 patients with cold type of obese asthma were randomly divided into control group and treatment group. Patients in the control group were given western medicine routine therapy. Patients in the treatment group were given basic treatment at the same time with Kechuan Liuwei Mixture treatment, the course of treatment was 2 weeks. The changes of TCM syndrome score, asthma control level test scale (ACT), quality of life score (AQLQ), lung function [forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow rate (PEF)] before and after treatment in 2 groups were observed. Results: After treatment, the total effective rate of TCM syndrome was 75% in the control group and 88.1% in the treatment group, and there was a statistical difference between the two groups (P < 0.05). The TCM syndrome scores (including wheezing, shortness of breath, cough, sputum and wheezing) in both groups were improved after treatment (P < 0.05), and the treatment group was better than the control group in improving wheezing, shortness of breath, cough and sputum (P < 0.05); AQLQ scores in both groups were improved, and the improvement degree in treatment group was better than that in control group (P < 0.05). ACT scores in both groups were improved, and the improvement in treatment group was significantly better than that in control group (P < 0.01). Lung function FVC, FEV1 and PEF were improved in both groups (P < 0.05), and FEV1 and PEF were improved in the treatment group more than in the control group (P < 0.05). Conclusion: The clinical efficacy of Kechuan Liuwei Mixture combined with western medicine routine therapy in the treatment of cold type obese asthma acute attack patients is obvious, which can significantly reduce the clinical symptoms, better control the asthma attacks, improve the quality of life, improve lung function and be worthy of further clinical promotion.