颅内动脉瘤发展过程中血流动力学与炎症的作用机制
Mechanism of Hemodynamics and Inflammation during Intracranial Aneurysm Development
DOI: 10.12677/ACM.2021.112066, PDF,    科研立项经费支持
作者: 高 超：复旦大学附属华山医院神经外科，上海
关键词: 颅内动脉瘤；破裂；血流动力学；炎症；Intracranial Aneurysm； Rupture； Hemodynamics； Inflammation
摘要: 血流动力学及血管病炎性反应是促进动脉瘤发展的重要因素。壁切应力驱动的内皮细胞炎症损伤是动脉瘤形成的始发病理变化。其次是基质金属蛋白酶破坏血管外基质，导致动脉瘤的形成和破裂。本文将探讨血流动力学造成的应激反应、血管病的炎性反应所导致的血管重塑与动脉瘤发展破裂的关系，有助于制定预测动脉瘤破裂风险的新策略。
Abstract: Hemodynamics and inflammatory response of vascular disease are important factors to promote the development of aneurysms. Wall shear stress-driven endothelial cell inflammatory injury is the initial pathological change of aneurysm formation, which is followed by matrix metalloproteinases that can destroy the extracellular matrix, leading to aneurysm formation and rupture. This paper will explore the relationship between vascular remodeling caused by hemodynamic stress and inflammatory response of vascular disease and aneurysm development rupture, in order to formulate a new strategy to predict the risk of aneurysm rupture.
文章引用：高超. 颅内动脉瘤发展过程中血流动力学与炎症的作用机制[J]. 临床医学进展, 2021, 11(2): 463-468. https://doi.org/10.12677/ACM.2021.112066

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