神经退行性疾病对艺术创造性的影响及其脑机制
Artistic Creativity Influenced by Neurodegenerative Diseases and its Related Neural Underpinnings
摘要: 神经退行性疾病是由大脑和脊髓神经元结构和功能的逐渐丧失导致的,阿兹海默和帕金森是最常见的神经退行性疾病,此外还包括癫痫以及额颞痴呆。有较多研究发现神经退行性疾病与艺术创造性之间存在一定联系,表现为神经退行性疾病患者在患病后其艺术创造性出现了提高或降低。本文以四种常见的神经退行性疾病为例,对神经退行性疾病影响艺术创造性的研究进行系统梳理和探讨,有助于厘清艺术创造性过程背后的神经机制。未来研究可以采用神经刺激手段对神经疾病患者艺术创造性有关的脑区进行调控,具体地考察大脑与艺术创造性之间的因果关系,并对如何切实提高个体的艺术创造性进行探索。通过对神经退行性疾病与艺术创造性关系的研究有助于加深对艺术创造性的了解,以期能够对未来有关艺术创造性的脑机制研究提供一些见解。
Abstract: Neurodegenerative diseases are mainly caused by progressive degeneration of nerve cells in the brain or peripheral nervous system of its function and structure. The most common ones are Alzheimer’s disease and Parkinson’s disease, epilepsy and frontotemporal dementia are also in-cluded. A large body of research provides evidence that there is association between neurodege-nerative diseases and artistic creativity in which patients exhibit increased or decreased artistic creativity. The present review starts from the four common neurodegenerative diseases, syste-matically goes through the literatures of neurodegenerative diseases and artistic creativity and further determines the neurological substrates of artistic creativity. One area that would be interesting to explore in future work is to administrate neuromodulation approach on the known regions of patients to investigate the causal relationship between brain and artistic creativity, therefore enhancing individual’s artistic creative ability. This study provides insight into the neural mechanisms underlying artistic creative performance and holds important implications for the research field of creativity.
文章引用:王茜 (2021). 神经退行性疾病对艺术创造性的影响及其脑机制. 心理学进展, 11(2), 381-393. https://doi.org/10.12677/AP.2021.112044

参考文献

[1] 张庆林(2002). 创造性研究手册: 成都: 四川教育出版社.
[2] Avila, A., Cardona, X., Bello, J., Maho, P., Sastre, F., & Martin-Baranera, M. (2011). Impulse Control Disorders and Punding in Parkinson’s Disease: The Need for a Structured Interview. Neurología, 26, 166-172.[CrossRef
[3] Bashwiner, D. M., Wertz, C. J., Flores, R. A., & Jung, R. E. (2016). Musical Creativity “Revealed” in Brain Structure: Interplay Between Motor, Default Mode, and Limbic Networks. Scientific Reports, 6, Article No. 20482.[CrossRef] [PubMed]
[4] Beatty, W. W., Zavadil, K. D., Bailly, R. C., Rixen, G. J. et al. (1988). Preserved Musical Skill in a Severely Demented Patient. International Journal of Clinical Neuropsychology, 10, 158-164.
[5] Bechtereva, N. P., Korotkov, A. D., Pakhomov, S. V., Roudas, M. S., Starchenko, M. G., & Medvedev, S. V. (2004). PET Study of Brain Maintenance of Verbal Creative Activity. International Journal of Psychophysiology, 53, 11-20.[CrossRef] [PubMed]
[6] Bergey, G. K. (2013). Neurostimulation in the Treatment of Epilepsy. Experimental Neurology, 244, 87-95.[CrossRef] [PubMed]
[7] Beversdorf, D. Q., Hughes, J. D., Steinberg, B. A., Lewis, L. D., & Heilman, K. M. (1999). Noradrenergic Modulation of Cognitive Flexibility in Problem Solving. NeuroReport, 10, 2763-2767.[CrossRef] [PubMed]
[8] Bogousslavsky, J. (2005). Artistic Creativity, Style and Brain Disorders. European Neurology, 54, 103-111.[CrossRef] [PubMed]
[9] Bolling, M. Y., & Kohlenberg, R. J. (2004). Reasons for Quitting Serotonin Reuptake Inhibitor Therapy: Paradoxical Psychological Side Effects and Patient Satisfaction. Psychotherapy and Psychosomatics, 73, 380-385.[CrossRef] [PubMed]
[10] Bromberger, B., Sternschein, R., Widick, P., Smith 2nd, W., & Chatterjee, A. (2011). The Right Hemisphere in Esthetic Perception. Frontiers in Human Neuroscience, 5, 109.[CrossRef] [PubMed]
[11] Canesi, M., Rusconi, M. L., Isaias, I., & Pezzoli, G. (2012). Artistic Productivity and Creative Thinking in Parkinson’s Disease. European Journal of Neurology, 19, 468-472.[CrossRef] [PubMed]
[12] Carlsson, I., Wendt, P. E., & Risberg, J. (2000). On the Neurobiology of Creativity. Differences in Frontal Activity between High and Low Creative Subjects. Neuropsychologia, 38, 873-885.[CrossRef
[13] Chakravarty, A. (2011). De Novo Development of Artistic Creativity in Alzheimer’s Disease. Annals of Indian Academy of Neurology, 14, 291-294.[CrossRef] [PubMed]
[14] Changeux, J.-P. (2005). Creation, Art, and the Brain. In J. P. Changeux, A. R. Damasio, W. Singer, & Y. Christen (Eds.), Neurobiology of Human Values (pp. 1-10). Berlin, Heidelberg: Springer.[CrossRef
[15] Chase, T. N., Fedio, P., Foster, N. L., Brooks, R., Di Chiro, G., & Mansi, L. (1984). Wechsler Adult Intelligence Scale Performance: Cortical Localization by Fluorodeoxyglucose F18-Positron Emission Tomography. Archives of Neurology, 41, 1244-1247.[CrossRef] [PubMed]
[16] Chatterjee, A., Hamilton, R. H., & Amorapanth, P. X. (2006). Art Produced by a Patient with Parkinson’s Disease. Behavioural Neurology, 17, 105-108.[CrossRef] [PubMed]
[17] Cowles, A., Beatty, W. W., Nixon, S. J., Lutz, L. J., Paulk, J., Paulk, K., & Ross, E. D. (2003). Musical Skill in Dementia: A Violinist Presumed to Have Alzheimer’s Disease Learns to Play a New Song. Neurocase, 9, 493-503.[CrossRef] [PubMed]
[18] Croisile, B., Ska, B., Brabant, M. J., Duchene, A., Lepage, Y., Aimard, G., & Trillet, M. (1996). Comparative Study of Oral and Written Picture Description in Patients with Alzheimer’s Disease. Brain and Language, 53, 1-19.[CrossRef] [PubMed]
[19] Crutch, S. J., Isaacs, R., & Rossor, M. N. (2001). Some Workmen Can Blame Their Tools: Artistic Change in an Individual with Alzheimer’s Disease. The Lancet, 357, 2129-2133.[CrossRef
[20] Cruz de Souza, L., Volle, E., Bertoux, M., Czernecki, V., Funkiewiez, A., Allali, G. et al. (2010). Poor Creativity in Frontotemporal Dementia: A Window into the Neural Bases of the Creative Mind. Neuropsychologia, 48, 3733-3742.[CrossRef] [PubMed]
[21] Crystal, H. A., Grober, E., & Masur, D. (1989). Preservation of Musical Memory in Alzheimer’s Disease. Journal of Neurology, Neurosurgery & Psychiatry, 52, 1415-1416.
[22] Cummings, J. L., & Cole, G. (2002). Alzheimer Disease. JAMA, 287, 2335-2338.[CrossRef] [PubMed]
[23] Cummings, J. L., & Zarit, J. M. (1987). Probable Alzheimer’s Disease in an Artist. JAMA, 258, 2731-2734.[CrossRef] [PubMed]
[24] Dietrich, A. (2004). The Cognitive Neuroscience of Creativity. Psychonomic Bulletin & Review, 11, 1011-1026.[CrossRef
[25] Dodrill, C. B., & Morris, G. L. (2001). Effects of Vagal Nerve Stimulation on Cognition and Quality of Life in Epilepsy. Epilepsy & Behavior, 2, 46-53.[CrossRef] [PubMed]
[26] Drago, Foster, P. S., Okun, M. S., Cosentino, F. I., Conigliaro, R., Haq, I. et al. (2009a). Turning off Artistic Ability: The Influence of Left DBS in Art Production. Journal of the Neurological Sciences, 281, 116-121.[CrossRef] [PubMed]
[27] Drago, V., Foster, P., Skidmore, F., & Heilman, K. (2009b). Creativity in Parkinson’s Disease as a Function of Right versus Left Hemibody Onset. Journal of the Neurological Sciences, 276, 179-183.[CrossRef] [PubMed]
[28] Edwards, C. A., Kouzani, A., Lee, K. H., & Ross, E. K. (2017). Neurostimulation Devices for the Treatment of Neurologic Disorders. Paper presented at the Mayo Clinic Proceedings, 92, 1427-1444.[CrossRef] [PubMed]
[29] Evans, A. H., Strafella, A. P., Weintraub, D., & Stacy, M. (2009). Impulsive and Compulsive Behaviors in Parkinson’s Disease. Movement Disorders, 24, 1561-1570.[CrossRef] [PubMed]
[30] Fink, A., Benedek, M., Grabner, R. H., Staudt, B., & Neubauer, A. C. (2007). Creativity Meets Neuroscience: Experimental Tasks for the Neuroscientific Study of Creative Thinking. Methods, 42, 68-76.[CrossRef] [PubMed]
[31] Fink, A., Grabner, R. H., Benedek, M., Reishofer, G., Hauswirth, V., Fally, M. et al. (2009). The Creative Brain: Investigation of Brain Activity during Creative Problem Solving by Means of EEG and FMRI. Human Brain Mapping, 30, 734-748.[CrossRef] [PubMed]
[32] Flaherty, A. W. (2005). Frontotemporal and Dopaminergic Control of Idea Generation and Creative Drive. Journal of Comparative Neurology, 493, 147-153.[CrossRef] [PubMed]
[33] Flaherty, A. W. (2011). Brain Illness and Creativity: Mechanisms and Treatment Risks. The Canadian Journal of Psychiatry, 56, 132-143.[CrossRef] [PubMed]
[34] Fornazzari, L. R. (2005). Preserved Painting Creativity in an Artist with Alzheimer’s Disease. European Journal of Neurology, 12, 419-424.[CrossRef] [PubMed]
[35] Fornazzari, L., Castle, T., Nadkarni, S., Ambrose, M., Miranda, D., Apanasiewicz, N., & Phillips, F. (2006). Preservation of Episodic Musical Memory in a Pianist with Alzheimer Disease. Neurology, 66, 610-611.[CrossRef
[36] Gardner, H. (1982). Artistry after Brain Damage. In Art, Mind, and Brain: A Cognitive Approach to Creativity (pp. 318-335). New York: Basic Books.
[37] Garrard, P., Maloney, L. M., Hodges, J. R., & Patterson, K. (2005). The Effects of Very Early Alzheimer’s Disease on the Characteristics of Writing by a Renowned Author. Brain, 128, 250-260.[CrossRef] [PubMed]
[38] Garrard, P., Ralph, M. A. L., Patterson, K., Pratt, K. H., & Hodges, J. R. (2005). Semantic Feature Knowledge and Picture Naming in Dementia of Alzheimer’s Type: A New Approach. Brain and Language, 93, 79-94.[CrossRef] [PubMed]
[39] Ghacibeh, G. A., & Heilman, K. M. (2013). Creative Innovation with Temporal Lobe Epilepsy and Lobectomy. Journal of the Neurological Sciences, 324, 45-48.[CrossRef] [PubMed]
[40] Ghacibeh, G. A., Shenker, J. I., Shenal, B., Uthman, B. M., & Heilman, K. M. (2006a). Effect of Vagus Nerve Stimulation on Creativity and Cognitive Flexibility. Epilepsy & Behavior, 8, 720-725.[CrossRef] [PubMed]
[41] Ghacibeh, G. A., Shenker, J. I., Shenal, B., Uthman, B. M., & Heilman, K. M. (2006b). The Influence of Vagus Nerve Stimulation on Memory. Cognitive and Behavioral Neurology, 19, 119-122.[CrossRef] [PubMed]
[42] Goel, V., & Grafman, J. (2000). Role of the Right Prefrontal Cortex in Ill-Structured Planning. Cognitive Neuropsychology, 17, 415-436.[CrossRef] [PubMed]
[43] Gruber, H. E., & Wallace, D. B. (1993). Introduction to Special Issue. Creativity Research Journal, 6, 1.[CrossRef
[44] Guilford, J. P. (1950). Creativity. American Psychologist, 5, 444-454.[CrossRef] [PubMed]
[45] Heilman, K. M., Nadeau, S. E., & Beversdorf, D. O. (2003). Creative Innovation: Possible Brain Mechanisms. Neurocase, 9, 369-379.[CrossRef] [PubMed]
[46] Hodges, J. R., Salmon, D. P., & Butters, N. (1992). Semantic Memory Impairment in Alzheimer’s Disease: Failure of Access or Degraded Knowledge? Neuropsychologia, 30, 301-314.[CrossRef
[47] Hoppe, K. D. (1988). Hemispheric Specialization and Creativity. Psychiatric Clinics of North America, 11, 303-315.[CrossRef
[48] Hu, B., Ross, L., Neuhaus, J., Knopman, D., Kramer, J., Boeve, B. et al. (2010). Off-Label Medication Use in Frontotemporal Dementia. American Journal of Alzheimer’s Disease and Other Dementias, 25, 128-133.[CrossRef] [PubMed]
[49] Inzelberg, R. (2013). The Awakening of Artistic Creativity and Parkinson’s Disease. Behavioral Neuroscience, 127, 256-261.[CrossRef] [PubMed]
[50] Jacobsen, T., & Hofel, L. (2002). Aesthetic Judgments of Novel Graphic Patterns: Analyses of Individual Judgments. Perceptual and Motor Skills, 95, 755-766.[CrossRef] [PubMed]
[51] Joutsa, J., Martikainen, K., & Kaasinen, V. (2012). Parallel Appearance of Compulsive Behaviors and Artistic Creativity in Parkinson’s Disease. Case Reports in Neurology, 4, 77-83.[CrossRef] [PubMed]
[52] Kane, N., & Kane, M. (1979). Comparison of Right & Left Hemisphere Functions. Gifted Child Quarterly, 23, 157-167.[CrossRef
[53] Kaplan, J. A., & Gardner, H. (1989). Artistry after Unilateral Brain Disease. In F. Boller (Ed.), Handbook of Neuropsychology (Vol. 2, pp. 141-155). Amsterdam: Elsevier.
[54] Kapur, N. (1996). Paradoxical Functional Facilitation in Brain-Behaviour Research. A Critical Review. Brain, 119, 1775-1790.[CrossRef] [PubMed]
[55] Kester, D. B., Saykin, A. J., Sperling, M. R., O’Connor, M. J., Robinson, L. J., & Gur, R. C. (1991). Acute Effect of Anterior Temporal Lobectomy on Musical Processing. Neuropsychologia, 29, 703-708.[CrossRef
[56] Kowatari, Y., Lee, S. H., Yamamura, H., Nagamori, Y., Levy, P., Yamane, S., & Yamamoto, M. (2009). Neural Networks Involved in Artistic Creativity. Human Brain Mapping, 30, 1678-1690.[CrossRef] [PubMed]
[57] Kulisevsky, J., Pagonabarraga, J., & Martinez-Corral, M. (2009). Changes in Artistic Style and Behaviour in Parkinson’s Disease: Dopamine and Creativity. Journal of Neurology, 256, 816-819.[CrossRef] [PubMed]
[58] Kumar, R., Lozano, A. M., Kim, Y. J., Hutchison, W. D., Sime, E., Halket, E., & Lang, A. E. (1998). Double-Blind Evaluation of Subthalamic Nucleus Deep Brain Stimulation in Advanced Parkinson’s Disease. Neurology, 51, 850-855.
[59] Lauring, J. O., Ishizu, T., Kutlikova, H. H., Dörflinger, F., Haugbøl, S., Leder, H. et al. (2019). Why Would Parkinson’s Disease Lead to Sudden Changes in Creativity, Motivation, or Style with Visual Art?: A Review of Case Evidence and New, Contextual, and Genetic Hypotheses. Neuroscience & Biobehavioral Reviews, 100, 129-165.[CrossRef] [PubMed]
[60] Magnus, R., & Laeng, B. (2006). Drawing on Either Side of the Brain. Laterality: Asymmetries of Body, Brain, and Cognition, 11, 71-89.[CrossRef] [PubMed]
[61] McChesney-Atkins, S., Davies, K. G., Montouris, G. D., Silver, J. T., & Menkes, D. L. (2003). Amusia after Right Frontal Resection for Epilepsy with Singing Seizures: Case Report and Review of the Literature. Epilepsy & Behavior, 4, 343-347.[CrossRef
[62] McManus, I. C., Chamberlain, R., Loo, P.-W., Rankin, Q., Riley, H., & Brunswick, N. (2010). Art Students Who Cannot Draw: Exploring the Relations between Drawing Ability, Visual Memory, Accuracy of Copying, and Dyslexia. Psychology of Aesthetics, Creativity, and the Arts, 4, 18-30.[CrossRef
[63] Mell, J. C., Howard, S. M., & Miller, B. L. (2003). Art and the Brain: The Influence of Frontotemporal Dementia on an Accomplished Artist. Neurology, 60, 1707-1710.[CrossRef
[64] Miller, B. L., & Hou, C. E. (2004). Portraits of Artists: Emergence of Visual Creativity in Dementia. Archives of Neurology, 61, 842-844.[CrossRef] [PubMed]
[65] Miller, B. L., Cummings, J., Mishkin, F., Boone, K., Prince, F., Ponton, M., & Cotman, C. (1998). Emergence of Artistic Talent in Frontotemporal Dementia. Neurology, 51, 978-982.[CrossRef
[66] Miller, B. L., Ponton, M., Benson, D. F., Cummings, J. L., & Mena, I. (1996). Enhanced Artistic Creativity with Temporal Lobe Degeneration. The Lancet, 348, 1744-1745.[CrossRef
[67] Miwa, H. (2007). Stereotyped Behavior or Punding in Parkinson’s Disease. Journal of Neurology, 254, 61-67.[CrossRef
[68] National Clinical Guideline Centre (2012). The Epilepsies: The Diagnosis and Management of the Epilepsies in Adults and Children in Primary and Secondary Care. UK: National Clinical Guideline Centre.
[69] Neary, D., Snowden, J., & Mann, D. (2005). Frontotemporal Dementia. The Lancet Neurology, 4, 771-780.[CrossRef
[70] Ohm, T., Müller, H., Braak, H., & Bohl, J. (1995). Close-Meshed Prevalence Rates of Different Stages as a Tool to Uncover the Rate of Alzheimer’s Disease-Related Neurofibrillary Changes. Neuroscience, 64, 209-217.[CrossRef
[71] Panebianco, M., Rigby, A., Weston, J., & Marson, A. G. (2015). Vagus Nerve Stimulation for Partial Seizures. Cochrane Database of Systematic Reviews, No. 4, CD002896.[CrossRef
[72] Pinker, S. (2002). Art Movements. CMAJ, 166, 224-224.
[73] Polk, M., & Kertesz, A. (1993). Music and Language in Degenerative Disease of the Brain. Brain and Cognition, 22, 98-117.[CrossRef] [PubMed]
[74] Rankin, K. P., Liu, A. A., Howard, S., Slama, H., Hou, C. E., Shuster, K., & Miller, B. L. (2007). A Case-Controlled Study of Altered Visual Art Production in Alzheimer’s and FTLD. Cognitive and Behavioral Neurology, 20, 48-61.[CrossRef
[75] Reitz, C., Brayne, C., & Mayeux, R. (2011). Epidemiology of Alzheimer Disease. Nature Reviews Neurology, 7, 137-152.[CrossRef] [PubMed]
[76] Reuter, M., Roth, S., Holve, K., & Hennig, J. (2006). Identification of First Candidate Genes for Creativity: A Pilot Study. Brain Research, 1069, 190-197.[CrossRef] [PubMed]
[77] Rizzolatti, G., Fogassi, L., & Gallese, V. (1997). Parietal Cortex: From Sight to Action. Current Opinion in Neurobiology, 7, 562-567.[CrossRef
[78] Sackeim, H. A., Keilp, J. G., Rush, A. J., George, M. S., Marangell, L. B., Dormer, J. S. et al. (2001). The Effects of Vagus Nerve Stimulation on Cognitive Performance in Patients with Treatment-Resistant Depression. Neuropsychiatry, Neuropsychology & Behavioral Neurology, 14, 53-62.
[79] Schrag, A., & Trimble, M. (2001). Poetic Talent Unmasked by Treatment of Parkinson’s Disease. Movement Disorders, 16, 1175-1176.[CrossRef] [PubMed]
[80] Schwingenschuh, P., Katschnig, P., Saurugg, R., Ott, E., & Bhatia, K. P. (2010). Artistic Profession: A Potential Risk Factor for Dopamine Dysregulation Syndrome in Parkinson’s Disease? Movement Disorders, 25, 493-496.[CrossRef] [PubMed]
[81] Seeley, W. W., Matthews, B. R., Crawford, R. K., Gorno-Tempini, M. L., Foti, D., Mackenzie, I. R., & Miller, B. L. (2007). Unravelling Boléro: Progressive Aphasia, Transmodal Creativity and the Right Posterior Neocortex. Brain, 131, 39-49.[CrossRef] [PubMed]
[82] Seger, C. A., Desmond, J. E., Glover, G. H., & Gabrieli, J. D. (2000). Functional Magnetic Resonance Imaging Evidence for Right-Hemisphere Involvement in Processing Unusual Semantic Relationships. Neuropsychology, 14, 361-369.[CrossRef
[83] Sellal, F., Andriantseheno, M., Vercueil, L., Hirsch, E., Kahane, P., & Pellat, J. (2003). Dramatic Changes in Artistic Preference after Left Temporal Lobectomy. Epilepsy & Behavior, 4, 449-450.[CrossRef
[84] Shimura, H., Tanaka, R., Urabe, T., Tanaka, S., & Hattori, N. (2012). Art and Parkinson’s Disease: A Dramatic Change in an Artist’s Style as an Initial Symptom. Journal of Neurology, 259, 879-881.[CrossRef] [PubMed]
[85] Snowden, J. S., Neary, D., & Mann, D. M. (2002). Frontotemporal Dementia. The British Journal of Psychiatry, 180, 140-143.[CrossRef] [PubMed]
[86] Snyder, A. (2009). Explaining and Inducing Savant Skills: Privileged Access to Lower Level, Less-Processed Information. Philosophical Transactions of the Royal Society B: Biological Sciences, 364, 1399-1405.[CrossRef] [PubMed]
[87] Venkatraman, V., Rosati, A. G., Taren, A. A., & Huettel, S. A. (2009). Resolving Response, Decision, and Strategic Control: Evidence for a Functional Topography in Dorsomedial Prefrontal Cortex. Journal of Neuroscience, 29, 13158-13164.[CrossRef
[88] Verrotti, A., Carrozzino, D., Milioni, M., Minna, M., & Fulcheri, M. (2014). Epilepsy and Its Main Psychiatric Comorbidities in Adults and Children. Journal of the Neurological Sciences, 343, 23-29.[CrossRef] [PubMed]
[89] Walker, R. H., Warwick, R., & Cercy, S. P. (2006). Augmentation of Artistic Productivity in Parkinson’s Disease. Movement Disorders, 21, 285-286.[CrossRef] [PubMed]
[90] Wise, R. A. (2005). Forebrain Substrates of Reward and Motivation. Journal of Comparative Neurology, 493, 115-121.[CrossRef] [PubMed]
[91] Witt, K., Krack, P., & Deuschl, G. (2006). Change in Artistic Expression Related to Subthalamic Stimulation. Journal of Neurology, 253, 955-956.[CrossRef] [PubMed]
[92] Zaidel, D. W. (2013). Split-Brain, the Right Hemisphere, and Art: Fact and Fiction. In Progress in Brain Research (Vol. 204, pp. 3-17). Amsterdam: Elsevier.[CrossRef
[93] Zatorre, R. J., & Halpern, A. R. (1993). Effect of Unilateral Temporal-Lobe Excision on Perception and Imagery of Songs. Neuropsychologia, 31, 221-232.[CrossRef
[94] Zubkov, S., & Friedman, D. (2016). Epilepsy Treatment and Creativity. Epilepsy & Behavior, 57, 230-233.[CrossRef] [PubMed]