血栓素A2在支气管哮喘中的作用
The Role of Thromboxane A2 in Bronchial Asthma
DOI: 10.12677/ACM.2021.112073, PDF,   
作者: 张子平：山东中医药大学，山东 济南；陈 娜：威海市中医院，山东 威海；张才擎*：山东省第二人民医院，山东省耳鼻喉医院，山东 济南
关键词: 支气管哮喘；TXA2；TXA2受体；Bronchial Asthma； TXA2； TXA2 Receptor
摘要: 血栓素A2 (Thromboxane, TXA2)是血小板花生四烯酸通过环氧合酶途径代谢所产生的一种脂质介质，也是目前所知最强的促血小板聚集剂和气道平滑肌收缩剂之一。根据目前研究，TXA2可由巨噬细胞、中性粒细胞、上皮细胞和平滑肌细胞等多种细胞和肺组织产生且分布广泛。近年来，国内外对支气管哮喘发病机制有诸多研究及结果，其中TXA2参与血管和呼吸道平滑肌的收缩，影响气道壁增厚与重塑，进而导致气道高反应性，这是哮喘发生的一个典型临床特征。进一步综合了解TXA2及其受体的生物学特性，阐明TXA2在支气管哮喘中的作用，以及目前抑制TXA的策略，有助于进一步为治疗支气管哮喘提供新的干预思路与方法。
Abstract: Thromboxane A2 (TXA2) is a lipid mediator produced by the metabolism of platelet arachidonic acid through the cyclocase pathway. It is also one of the most powerful platelet aggregation agents and airway smooth muscle contractors known to date. According to current studies, TXA2 can be produced and widely distributed by macrophages, neutrophils, epithelial cells, smooth muscle cells and other cells and lung tissues. In recent years, there have been many studies and results on the pathogenesis of bronchial asthma at home and abroad. Among them, TXA2 is involved in the contraction of vascular and respiratory smooth muscle, which affects the thickening and remodeling of airway wall and thus leads to airway hyperreactivity, which is a typical clinical feature of asthma. Further comprehensive understanding of the biological characteristics of TXA2 and its receptors, elucidating the role of TXA2 in bronchial asthma and current strategies for inhibiting TXA will help to further provide new ideas and methods for the treatment of bronchial asthma.
文章引用：张子平, 陈娜, 张才擎. 血栓素A2在支气管哮喘中的作用[J]. 临床医学进展, 2021, 11(2): 512-518. https://doi.org/10.12677/ACM.2021.112073

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