Cu2O-ZnO纳微异质结构生物H2S感知特性研究
Biological H2S Sensing Characteristics of Cu2O/ZnO Nano-Micro Heterostructure
DOI: 10.12677/CMP.2021.101004, PDF,    国家自然科学基金支持
作者: 狄文浩, 崔光亮, 张品华：临沂大学物理与电子工程学院，山东 临沂；薛凯峰：临沂大学机械与车辆工程学院，山东 临沂
关键词: H2S；生物传感器；电沉积；H2S； Biosensor； Electrodeposition
摘要: H2S是继NO和CO人们发现的第三种内源性气体信号分子，在生物体的很多生理过程中表现出非常重要的生物学活性，尤其在高血压、心脑系统疾病、2型糖尿病、结肠癌等疾病的诊断和治疗方面起着重要的作用。由于生物体内H2S的浓度会随着某些慢性疾病病变程度不同而发生相应变化，因此生物体内H2S的浓度可以看作这些疾病诊断与治疗的标志物，所以实现生物体内H2S浓度的快速检测对人类健康具有重要的意义。本研究利用电化学原位组装方法，构建基于氧化亚铜和氧化锌的特殊纳微有序阵列材料，基于异质界面的电导调控、以及材料表面硫化反应，该纳微结构表现出优异的生物H2S传感特性。因此提出一种生物H2S标志物的快速检测方案，实现相关疾病的诊断与实时监测的目的。实验结果证实，基于该研究体系的生物H2S检测范围为1~1000 μmol/L，且具有良好的线性关系，达到了人体实际检测的应用要求，在相关疾病的家庭式监测应用方面具有巨大的潜力。
Abstract: H2S is the third endogenous gas signaling molecule discovered after NO and CO, showing very important biological activities in many physiological processes of organisms, especially in the diagnosis and treatment of hypertension, cardio-brain diseases, type 2 diabetes, colon cancer and other diseases. Since the concentration of H2S in organisms will change with some chronic diseases, the H2S in organisms can be regarded as a marker for these diseases, so the rapid detection of H2S concentration in organisms is of great significance to human health. Cuprous oxide and zinc oxide based nano-micro ordered arrays were prepared by an in situ electrodeposition method. Based on the conductance modulation of the heterointerface and the surface vulcanization reaction of the material, the heterostructure shows excellent biological H2S sensing characteristics. Therefore, a rapid detection scheme of biological H2S markers is proposed to realize the diagnosis and real-time monitoring of related diseases. The experimental results confirm that the biological H2S detection range based on this heterostructure is 1~1000 μmol/L with good linear relationship. It meets the practical application requirements of human detection, has a great potential in the application of home monitoring of related diseases. It meets the application requirements of human body, and has great potential in the application of home monitoring of related diseases.
文章引用：狄文浩, 崔光亮, 张品华, 薛凯峰. Cu2O-ZnO纳微异质结构生物H2S感知特性研究[J]. 凝聚态物理学进展, 2021, 10(1): 25-32. https://doi.org/10.12677/CMP.2021.101004

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