无极石英晶体微天平化学生物传感器
Electrodeless Quartz Crystal Microbalance Chemo/Biosensor
DOI: 10.12677/AAC.2021.111001, PDF,    国家自然科学基金支持
作者: 扶梅, 司士辉*, 冯浪霞, 张 润：中南大学化学化工学院，湖南 长沙；陈金华：湖南大学化学生物传感与计量学国家重点实验室，湖南 长沙
关键词: 石英晶体微天平；无极激励；信号测量方法；生物传感；化学传感；Quartz Crystal Microbalance； Electrodeless Excitation； Signal Measurement Method； Biosensing； Chemosensing
摘要: 石英晶体微天平传感器是一种灵敏度可达纳克级甚至皮克级的质量型传感测量技术，在高灵敏化学检测、非标记生物传感领域具有广泛应用价值。无金属激励电极裸石英晶体微天平传感器突破了传统石英晶体微天平传感模式，在高频石英晶体高灵敏质量传感、石英晶体微阵列检测等领域表现出诸多的优点和独特的应用价值。本文对无极石英晶体微天平传感器进行了全面的梳理和总结。首先，从无极石英晶体的等效电路模型出发，简单介绍了无极石英晶体传感器的传感原理，阐述了无极石英晶体振动激励方法的演变历程。然后，重点讨论了四种无极石英晶体传感器的信号测量方法，包括振荡器法、阻抗分析法、QCM-D测量法、电磁压电声学测量法等，分别论述了其原理及发展趋势。最后，归纳了无极石英晶体微天平传感器在化学生物传感领域的研究现状，并展望了其未来的发展。
Abstract: Quartz crystal microbalance sensor is a kind of nanogram or even picogram grade mass sensing measurement technology. It has a wide range of applications in the fields of highly sensitive chemical detection and non-labeled biosensing. The bare quartz crystal microbalance sensor without metal excitation electrode breaks through the traditional quartz crystal microbalance sensing mode, and shows many advantages and unique application values in the fields of high-frequency quartz crystal high-sensitivity quality sensing and quartz crystal microarray detection. This article has carried on a comprehensive combing and summarizing to the electrodeless quartz crystal sensor. Firstly, starting from the equivalent circuit model of the electrodeless quartz crystal, the sensing theory of the electrodeless quartz crystal sensor is briefly introduced, and the evolution process of the oscillation excitation method of the electrodeless quartz crystal is explained. Secondly, four kinds of signal measurement methods of the electrodeless quartz crystal sensor are emphatically discussed, including oscillator method, impedance analysis method, QCM-D method, electromagnetic piezoelectric acoustic method, and their principles and development trends are discussed respectively. Finally, the research status of the electrodeless quartz crystal microbalance sensor in the field of chemo/biosensing is summarized, and its future development is prospected.
文章引用：扶梅, 司士辉, 陈金华, 冯浪霞, 张润. 无极石英晶体微天平化学生物传感器[J]. 分析化学进展, 2021, 11(1): 1-15. https://doi.org/10.12677/AAC.2021.111001

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