右美托咪定肺保护作用及其机制的研究进展
Research Progress of Lung Protective Effect and Mechanism of Dexmedetomidine
DOI: 10.12677/ACM.2021.112095, PDF,   
作者: 孙倩倩, 赵欣荣：延安大学附属医院麻醉与围术期医学科，陕西 延安；白智远：延安大学附属医院老年呼吸科，陕西 延安
关键词: 右美托咪定；器官保护作用；肺保护；机制；Dexmedetomidine； Organ Protection Effect； Lung Protection； Mechanism
摘要: 右美托咪定是一种选择性α2肾上腺素受体激动剂，具有镇静、镇痛、抗焦虑等药理作用，因其“可唤醒”的镇静特点及无明显呼吸抑制的优点被广泛用于临床。近年来，随着研究者们对该药的关注，发现其可通过减少细胞凋亡、抑制中性粒细胞聚集、降低气道反应性等多种途径的参与在许多临床情境中均可发挥器官保护作用，其中肺保护作用尤为明显。
Abstract: Dexmedetomidine is a selective alpha 2 adrenergic receptor agonist, it has sedative, analgesic, anti-anxiety and other pharmacological effects. It is widely used in clinical practice due to its “evocative” sedative characteristics and the advantages of no obvious respiratory inhibition. In recent years, with the attention of researchers, it has been found that the drug can play an organ protection role in many clinical situations by reducing apoptosis, inhibiting neutrophil aggregation, reducing airway reactivity and other ways, especially lung protection.
文章引用：孙倩倩, 赵欣荣, 白智远. 右美托咪定肺保护作用及其机制的研究进展[J]. 临床医学进展, 2021, 11(2): 655-661. https://doi.org/10.12677/ACM.2021.112095

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