补体系统在膜性肾病发病机制中的研究进展

Advances in the Study of Complement System in Pathogenesis of Membranous Nephropathy

摘要: 膜性肾病是成人肾病综合征最常见的病理类型之一，在儿童中的发病率也逐年升高，其典型病理表现为肾小球脏层上皮细胞下免疫复合物沉积。免疫复合物可激活补体系统，最终形成膜攻击复合物，导致肾脏损伤。目前关于补体系统在膜性肾病的发病机制中的具体作用不详，本文将从动物实验、补体系统激活、补体系统调节等几方面阐述膜性肾病的发病机制研究进展。

Abstract: Membranous nephropathy is one of the most common pathological types of nephrotic syndrome in adults, and the incidence of membranous nephropathy is increasing in recent years. The typical pathological manifestation of membranous nephropathy is immune complex deposition under the podocyte cells. The immune complex activates the complement system and forms the membrane attack complex. Finally, the membrane attack complex leads to kidney injury. At present, the specific role of the complement system in the pathogenesis of membranous nephropathy is unknown. This article will discuss the advances in the study of the complement system in the pathogenesis of membranous nephropathy from animal experiments, complement system activation, and complement system regulation.