术前炎性指标评估喉癌复发的临床意义

The Clinical Significance of Preoperative Inflammatory Indexes in Evaluating the Recurrence of Laryngeal Carcinoma

摘要: 目的：探讨术前中性粒细胞、淋巴细胞、单核细胞、血小板、中性粒细胞淋巴细胞比率(NLR)、血小板淋巴细胞比率(PLR)、淋巴细胞单核细胞比率(LMR)与喉鳞状细胞癌复发的关联及临床意义。方法：对在青岛大附属医院初次手术治疗的196例喉鳞状细胞癌患者进行回顾性研究，收集符合标准患者的临床数据及炎性指标数据，炎性指标数据用均数 ± 标准差(x ± s)表示，采用t检验和单因素方差分析或者Mann-Whitney U秩和检验和Kruskal-Wallis检验分析炎性指标与喉癌复发的关联。结果：单一性炎性指标中，仅淋巴细胞与喉癌的复发存在统计学意义(P < 0.01)，在复合性炎症指标中，NLR、PLR、LMR都是显著影响喉癌复发的因素(P < 0.01)。淋巴结转移、T分期越大、临床分期越晚，NLR和PLR则越高，而LMR越低。结论：术前NLR、PLR升高以及淋巴细胞、LMR降低可用于预测喉癌的复发。

Abstract: Objective: To investigate the correlation and clinical significance of preoperative neutrophils, lymphocytes, monocytes, platelets, neutrophilto lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and recurrence of laryngeal squamous cell carcinoma (LSCC). Methods: A retrospective study was conducted on 196 patients with laryngeal squamous cell carcinoma who were treated for the first time in Qingdao University Hospital. The clinical data and inflammatory index data of patients meeting the standards were collected. The inflammatory index data was used as mean ± standard deviation (x ± s) means that the t-test and one-way analysis of variance or Mann-Whitney U rank sum test and Kruskal-Wallis test are used to analyze the association between inflammatory indicators and the recurrence of laryngeal cancer. Results: Among the single inflammatory indexes, only the recurrence of lymphocytes and laryngeal cancer was statistically significant (P < 0.01). Among the complex inflammatory indexes, NLR, PLR, and LMR were all significant factors affecting the recurrence of laryngeal cancer (P < 0.01). Lymph node metastasis, the larger the T stage, the later the clinical stage, result of the higher the NLR and PLR, and the lower the LMR. Conclusion: Preoperative increase in NLR or PLR and decrease in lymphocytes or LMR can be used to predict the recurrence of laryngeal cancer.