急性冠脉综合征患者血清胱抑素C水平与冠脉病变程度的关系

Association of Serum Cystatin C Levels with Disease Severity in Patients with Acute Coronary Syndrome

摘要: 目的：探讨血清胱抑素C水平(CysC)与急性冠脉综合征(Acute coronary syndrome, ACS)患者冠脉病变程度的关系。方法：选取经冠状动脉造影检查确诊ACS的253例患者作为观察组，40例同期经冠脉造影检查排除冠心病的患者作为对照组。入院后检测患者次日晨起空腹血清胱抑素C水平，将ACS患者血清CysC水平与Gensini评分作相关性分析。结果：随着冠脉病变程度的增加，血清CysC、尿酸(UA)水平逐渐升高，组间比较差异均有统计学意义(P < 0.01)。血清CysC、UA水平与ACS患者Gensini评分呈正相关(P < 0.05)，是影响Gensini评分的危险因素(P < 0.05)。结论：ACS患者血清CysC、UA水平与冠脉病变严重程度相关，是使冠脉病变程度加重的危险因素。对ACS患者进行监测和早期干预治疗，有助于预防心血管不良事件的发生。

Abstract: Objective: To investigate the correlation between coronary artery lesion score and serum cystatin C (CysC) level in acute coronary syndrome (ACS). Methods: 253 patients were admitted from January 2019 to December 2019 with ACS and 39 patients without ACS (the control group) were enrolled in the study. All subjects underwent coronary angiography. ACS patients were divided into the low score group, the middle score group and the high score group by coronary artery stenosis score (Gensini); patients in the control group were excluded with coronary artery disease by coronary angiography. Serum CysC levels were measured within 24 h after admission. The correlation between CysC level and Gensini score was compared. Results: With the increase of severity of coronary artery disease, the levels of CysC and uric acid (UA) were increased. The difference between groups was highly statistically significant (P < 0.01). Logistic regression analysis showed that Gensini scores were positively correlated with levels of CysC and UA (P < 0.05). High serum CysC and UA levels were independent risk factors for high Gensini scores. Conclusion: The levels of serum CysC and UA in ACS patients are related to the severity of coronary artery lesion, and are the risk factors of the severity of coronary artery lesion. In clinical work, monitoring of the above indicators and early intervention therapy for ACS patients were of great clinical significance for preventing the occurrence of acute coronary events.